Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dennis M, Freeman"'
Autor:
Dennis M. Freeman, Daniel Filizzola, Mary Ann Cheatham, Amer Mansour, Jonathan B. Sellon, Roozbeh Ghaffari
Publikováno v:
Biophysical journal. 120(21)
Studies of genetic disorders of sensorineural hearing loss have been instrumental in delineating mechanisms that underlie the remarkable sensitivity and selectivity that are hallmarks of mammalian hearing. For example, genetic modifications of TECTA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6a767256b20c2c45c080e44ea4dd01
https://pubmed.ncbi.nlm.nih.gov/34555361
https://pubmed.ncbi.nlm.nih.gov/34555361
Autor:
Donglai Wei, Roozbeh Ghaffari, Michael Rubinstein, Oral Buyukozturk, Neal Wadhwa, Katia Bertoldi, Frédo Durand, Justin G. Chen, S. Sun, Jonathan B. Sellon, Pai Wang, William T. Freeman, Dennis M. Freeman, Sung Hoon Kang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Humans have difficulty seeing small motions with amplitudes below a threshold. Although there are optical techniques to visualize small static physical features (e.g., microscopes), visualization of small dynamic motions is extremely dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e870baf46902ac203e71dd4df78bf
https://doi.org/10.1073/pnas.1703715114
https://doi.org/10.1073/pnas.1703715114
Autor:
Jonathan B. Sellon, Roozbeh Ghaffari, Dennis M. Freeman, Hideko Heidi Nakajima, Shirin Farrahi
Publikováno v:
Elsevier
Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5050531bb2b94a9475caa11ec3c326
Autor:
Jonathan B. Sellon, Ramin Oftadeh, Alan J. Grodzinsky, Dennis M. Freeman, Roozbeh Ghaffari, Mojtaba Azadi, Hadi Tavakoli Nia
Publikováno v:
American Physical Society
Stereociliary imprints in the tectorial membrane (TM) have been taken as evidence that outer hair cells are sensitive to shearing displacements of the TM, which plays a key role in shaping cochlear sensitivity and frequency selectivity via resonance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecb8fead21f2e30a635f724dd55ff43
https://orcid.org/0000-0002-4942-3456
https://orcid.org/0000-0002-4942-3456
Publikováno v:
Prof. Freeman via Phoebe Ayers
The tectorial membrane (TM) is widely believed to play a critical role in determining the remarkable sensitivity and frequency selectivity that are hallmarks of mammalian hearing. Recently developed mouse models of human hearing disorders have provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc8ae8c725ba2ae79801bee35ceafa
https://hdl.handle.net/1721.1/122653
https://hdl.handle.net/1721.1/122653
Autor:
Roozbeh Ghaffari, Jonathan B. Sellon, Shirin Farrahi, Hideko Heidi Nakajima, Dennis M. Freeman
Publikováno v:
Prof. Freeman via Phoebe Ayers
It has been suggested that humans discriminate different frequency sounds with greater selectivity than other mammals. However, mechanisms that could underlie higher frequency selectivity in humans are unclear. Recent studies show that the tectorial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4288cd4ae4a4fdc0366fa86d94805d6
https://hdl.handle.net/1721.1/122671
https://hdl.handle.net/1721.1/122671
Publikováno v:
Prof. Freeman via Phoebe Ayers
It has been suggested that the decay constants of tectorial membrane (TM) traveling waves contribute to differences in the tuning of Tectb −/– mutant mice, wild-type mice, and humans. However, the experiments underlying these results were obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9116e8d95fd5cc394005ee72089c51
https://doi.org/10.1063/1.5038466
https://doi.org/10.1063/1.5038466
Publikováno v:
AIP Conference Proceedings.
Knowledge of the mechanical properties of the tectorial membrane (TM) would improve the understanding of TM function in hearing mechanics. In recent years, several groups have used measurements of wave propagation on isolated TMs to estimate the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b923432bb7facb9baa4fff61e0f02a
https://doi.org/10.1063/1.5038464
https://doi.org/10.1063/1.5038464
Publikováno v:
Understanding the Cochlea ISBN: 9783319520711
The basis of the extraordinary sensitivity and frequency selectivity of the mammalian cochlea is an electromechanical feedback system that amplifies the deflection of the hair cell stereocilia. Electromechanical force is generated by the soma of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a25d52e56f98f1b0eb0692f1e50f69
https://doi.org/10.1007/978-3-319-52073-5_6
https://doi.org/10.1007/978-3-319-52073-5_6
Publikováno v:
Cold Spring Harb Perspect Med
The tectorial membrane (TM) is widely believed to play a critical role in determining the remarkable sensitivity and frequency selectivity that are hallmarks of mammalian hearing. Recently developed mouse models of human hearing disorders have provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8130a6ec22cc9552aa7c0c7d8667f0d
https://doi.org/10.1101/cshperspect.a038950
https://doi.org/10.1101/cshperspect.a038950