Primary blood neutrophils express a functional cell surface Toll-like receptor 9

Autor: Patrice Decker, Ivan Jelcic, Britta Janina Wagner, Marie-Christophe Boissier, Dennis Lindau, Hans-Georg Rammensee, Maude Quettier, Matthieu Ribon, Julie Mussard, Viktoria M. Rönnefarth

Publikováno v: European Journal of Immunology. 43:2101-2113

Polymorphonuclear leukocytes (PMNs) represent one of the first lines of defense against pathogens. TLR9 is normally expressed in endosomes/lysosomes where it is activated by pathogen-derived DNA. Here we show that freshly isolated human and mouse pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c7993e61fdfe73c9d8ed254c3eb31c8
https://doi.org/10.1002/eji.201142143

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

Autor: Paul R. Gielen, Gosse J. Adema, Michiel Kroesen, Dennis Lindau, Pieter Wesseling

Publikováno v: Immunology, 138, 2, pp. 105-15
Immunology, 138, 105-15
Lindau, D, Gielen, P, Kroesen, M, Wesseling, P & Adema, G J 2013, ' The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells ', Immunology, vol. 138, no. 2, pp. 105-115 . https://doi.org/10.1111/imm.12036
Immunology, 138(2), 105-115. Wiley-Blackwell

Item does not contain fulltext Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the immune suppressive tumour microenvironment (TME). Both cell types expand systematically in preclinical tumour models and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e738bf3ed7ab12dc0d4c1bb05f20914
https://hdl.handle.net/2066/117802

Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and beta1 integrin

Autor: B. Gückel, Gerd Klein, Jörg Glatzle, Dennis Lindau, Stefan Löb, Helen Hörzer, Hans-Georg Rammensee, Björn L.D.M. Brücher, Britta Janina Wagner, Alfred Königsrainer

Publikováno v: International Journal of Oncology, 39, 6, pp. 1593-600
International Journal of Oncology, 39, 1593-600

Item does not contain fulltext Peritoneal carcinomatosis describes cancer metastasis onto the surface of the peritoneum. It is frequently caused by ovarian and colorectal cancer. Once a tumor has penetrated the peritoneum, cancer cells disseminate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f41be60d1aae3e960bd9eb5c8e51f03
https://doi.org/10.3892/ijo.2011.1167

Nph, DC and chromatin-mediated pathogenesis in systemic lupus erythematosus

Autor: Dennis Lindau, Patrice Decker

Publikováno v: Autoimmunity. 42(4)

Nucleosomes (Nuc) are key lupus autoantigen and have been shown to activate several types of immune cells as well as the complement system, resulting in inflammation. The elevated concentrations and the immunostimulatory capacities of circulating Nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a60a1e675768f925cd60de4e025b29a
https://pubmed.ncbi.nlm.nih.gov/19811268

Chromatin-activated neutrophils represent a major source of interferon

Autor: Annette Igney, Armin Rabsteyn, Marie-Christophe Boissier, Patrice Decker, Ina Kötter, Hans-Georg Rammensee, Dennis Lindau

Publikováno v: Annals of the Rheumatic Diseases. 70:A38-A39

Background and objectives Nucleosomes (DNA-histones complexes) represent major autoantigens present in the circulation of systemic lupus erythematosus (SLE) patients. Interferon α (IFNα) plays an important role in lupus development. Although activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea8fa3cffbdde15cf4a00d1f4ebb04aa
https://doi.org/10.1136/ard.2010.148973.7