Výsledky vyhledávání - "Dennis Liang Fei"

Akademický článek

The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Autor: Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas, David J. Robbins

Publikováno v: Environmental Health, Vol 16, Iss 1, Pp 1-9 (2017)

Abstract Background Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist during fetal developmen

Externí odkaz: https://doaj.org/article/2fd35b02983a4639922d99b0ae8e2afc

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Akademický článek

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival.

Autor: Dennis Liang Fei, Hayley Motowski, Rakesh Chatrikhi, Sameer Prasad, Jovian Yu, Shaojian Gao, Clara L Kielkopf, Robert K Bradley, Harold Varmus

Publikováno v: PLoS Genetics, Vol 12, Iss 10, p e1006384 (2016)

We have asked how the common S34F mutation in the splicing factor U2AF1 regulates alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this mutation. A human lung epithelial cell line was genetically modified so th

Externí odkaz: https://doaj.org/article/920131dbdd724f3ab20d3c18f0c03afd

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Akademický článek

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Autor: Bin Li, Colin A Flaveny, Camilla Giambelli, Dennis Liang Fei, Lu Han, Brian I Hang, Feng Bai, Xin-Hai Pei, Vania Nose, Oname Burlingame, Anthony J Capobianco, Darren Orton, Ethan Lee, David J Robbins

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101969 (2014)

Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal canc

Externí odkaz: https://doaj.org/article/0534dfbdefa84db8a2507a5d09cc0d62

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