The Putative Secreted Serine Protease Chp-7 Is Required for Full Virulence and Induction of a Nonhost Hypersensitive Response by Clavibacter michiganensis subsp. sepedonicus

Autor: Riitta Nissinen, Yunjian Xia, Laura Mattinen, Carol A. Ishimaru, Dennis L. Knudson, Susan E. Knudson, Mary Metzler, Minna Pirhonen

Publikováno v: Molecular Plant-Microbe Interactions, Vol 22, Iss 7, Pp 809-819 (2009)

Molecular biological studies on Clavibacter michiganensis subsp. sepedonicus, the causal agent of bacterial ring rot of potato, have gained greater feasibility due to the recent availability of whole genomic sequences and genetic tools for related ta

Externí odkaz: https://doaj.org/article/480ad020da564e83a01ad2162276a40d

Genome sequence of Aedes aegypti, a major arbovirus vector

Autor: Sergio Verjovski-Almeida, James E. Galagan, Ryan C. Kennedy, Zhiyong Xi, Jason R. Miller, Eric Eisenstadt, Kyanne R. Reidenbach, Robert V. Bruggner, Yu-Hui Rogers, Hadi Quesneville, Doreen Werner, Owen White, Alexander S. Raikhel, Mario Stanke, J. Spencer Johnston, Diane D. Lovin, Evgenia V. Kriventseva, Ian T. Paulsen, Kathryn S. Campbell, Norman H. Lee, Ewan Birney, Karyn Megy, Hean Koo, David Kulp, Shelby L. Bidwell, Jingsong Zhu, Philip Montgomery, Paolo Amedeo, Yongmei Zhao, Chinnappa D. Kodira, Javier Costas, Michael C. Schatz, Steven P. Sinkins, Claire M. Fraser-Liggett, Martin Shumway, Kurt LaButti, Akio Mori, Brendan J. Loftus, Manfred Grabherr, Eric O. Stinson, Frank H. Collins, Zhijian Jake Tu, Monique R. Coy, Matt Crawford, Janice P. Vanzee, William M. Gelbart, Joshua Orvis, Peter Arensburger, Chunhong Mao, Evgeny M. Zdobnov, Saul A. Kravitz, Suely Lopes Gomes, David DeCaprio, David G. Hogenkamp, Daniel Lawson, Dennis L. Knudson, David W. Severson, George Dimopoulos, Marcelo B. Soares, Sinéad B. O'Leary, Peter W. Atkinson, David M. Jaffe, Becky deBruyn, Martin Hammond, Ana L. T. O. Nascimento, Jim Biedler, Stefan Wyder, Jose M. C. Tubio, Bruce W. Birren, Catherine A. Hill, Chad Nusbaum, Eduardo Lee, Song Li, Susan E. Brown, Jennifer R. Wortman, James R. Hogan, Hamza El-Dorry, Qi Zhao, Linda Hannick, Carlos Frederico Martins Menck, Vishvanath Nene, Jonathan Crabtree, Steven L. Salzberg, Michael H. Holmes, Maria de Fatima Bonaldo, Quinghu Ren, Mihaela Pertea, Charles Roth, Evan Mauceli, Karin Eiglmeier, Horacio Naveira, Brian J. Haas, Qiandong Zeng, Neil F. Lobo, Jennifer R. Schneider

Publikováno v: Science
Science, American Association for the Advancement of Science, 2007, 316 (5832), pp.1718-23. 〈10.1126/science.1138878〉
Science, American Association for the Advancement of Science, 2007, 316 (5832), pp.1718-23. ⟨10.1126/science.1138878⟩
Science, 2007, 316 (5832), pp.1718-23. ⟨10.1126/science.1138878⟩
Science, Vol. 316, No 5832 (2007) pp. 1718-1723

We present a draft sequence of the genome of Aedes aegypti , the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae . Nearly 50% of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701bca49fefccd61cb20d80a44096035
https://doi.org/10.1126/science.1138878

Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis: Residence Time and in Vivo Activity

Autor: Nicole L. Marlenee, B. Gopal Reddy, Peter J. Tonge, Richard A. Bowen, Susan E. Knudson, Richard A. Slayden, Kathleen England, Hao Lu, Dennis L. Knudson, Christopher W. am Ende, Caroline Kisker, James J. Truglio, Sylvia R. Luckner

Publikováno v: ACS Chemical Biology. 4:221-231

Francisella tularensis is a highly virulent and contagious Gram-negative intracellular bacterium that causes the disease tularemia in mammals. The high infectivity and the ability of the bacterium to survive for weeks in a cool, moist environment hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88fa8bf7fcd94b70feb7ea70bc962db
https://doi.org/10.1021/cb800306y

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

Autor: Todd J. Sullivan, James E. Childs, Francis Johnson, Richard A. Slayden, Hua Xu, Christopher W. am Ende, Melissa E. Boyne, Susan E. Knudson, Charles A. Peloquin, Nina Liu, Peter J. Tonge, Yelizaveta Gegina, Dennis L. Knudson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:3029-3033

Previous structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 are nM inhibitors of InhA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e060070e01beee75fb8a69548e8e3437
https://doi.org/10.1016/j.bmcl.2008.04.038

Use of Protein Microarrays To Define the Humoral Immune Response in Leprosy Patients and Identification of Disease-State-Specific Antigenic Profiles

Autor: Patrick J. Brennan, Nathan A. Groathouse, Amol G. Amin, Maria Angela M. Marques, John T. Belisle, Dennis L. Knudson, Richard A. Slayden, John S. Spencer, Robert H. Gelber

Publikováno v: Infection and Immunity. 74:6458-6466

Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574655ea0815c5f9a45250bf482b65ab
https://doi.org/10.1128/iai.00041-06