Výsledky vyhledávání - "Dennis L. Cook"

Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations

Autor: Consuelo L. McCash, Dennis L. Cook, Ofelia A. Olivero, Meghan M. Carter, Vernon E. Walker, Salina M. Torres, Miriam C. Poirier, Dale M. Walker, Edmund M. Cordova

Publikováno v: Environmental and Molecular Mutagenesis. 48:224-238

Experiments were performed to investigate the impact of zidovudine (AZT), lamivudine (3TC), and abacavir (ABC) on cell survival and mutagenicity in two reporter genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and thymidine kinase (TK), u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590bf6bd595b2c57799b8423f54dbe10
https://doi.org/10.1002/em.20264

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In Situ Analysis of Interleukin-1-Induced Transcription of cox-2 and il-8 in Cultured Human Myometrial Cells

Autor: Yow-Jiun Jeng, Garland D. Anderson, Melvyn S. Soloff, Dennis L. Cook

Publikováno v: Endocrinology. 145:1248-1254

The specific binding of transcription factors to DNA has been shown to be inhibited by chromatin structure and increased by cooperative interactions with other proteins. Consequently, in situ analysis using chromatin immunoprecipitation offers the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b1d6407a5c38da6dda7d042350c2c3
https://doi.org/10.1210/en.2003-1310

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Persistence of Mitochondrial Toxicity in Hearts of Female B6C3F1 Mice Exposed In Utero to 3'-Azido-3'-Deoxythymidine

Autor: Amie K. Lund, Kunio Nagashima, Matthew J. Campen, Patsy Y. Cossey, Vernon E. Walker, Fletcher F. Hahn, Rao L. Divi, Miriam C. Poirier, Dale M. Walker, Dennis L. Cook

Publikováno v: Cardiovascular Toxicology. 4:133-154

Cardiac toxicity has been associated with HIV infection and exposure to nucleoside reverse transcriptase inhibitors (NRTIs), but the role of the latter in the development of cardiac disease of HIV-infected patients is uncertain. To investigate the ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73fe73563ea5ccc3b15f0b71856f3215
https://doi.org/10.1385/ct:4:2:133

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Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1

Autor: Edmund M. Cordova, Rachel M. Pons, Salina M. Torres, Consuelo L. McCash, Steven K. Seilkop, Vernon E. Walker, Jessica Ming, Dale M. Walker, William C. Copeland, Dennis L. Cook, Meghan M. Carter

Publikováno v: Environmental and molecular mutagenesis. 50(1)

A sensitive vertical denaturing gradient gel electrophoresis (DGGE) method, using 13 unipolar psoralen-clamped PCR primer pairs, was developed for detecting sequence variants in the 22 tRNA genes and flanking regions (together spanning approximately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e47caf78c894fe0a5138b127452fb8
https://pubmed.ncbi.nlm.nih.gov/19031409

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Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells

Autor: Vernon E. Walker, Mia Yu, Consuelo L. McCash, Dennis L. Cook, Salina M. Torres, Dale M. Walker, Meghan M. Carter

Publikováno v: Environmental and molecular mutagenesis. 48(3-4)

Experiments were performed to investigate the impact of didanosine (ddI), lamivudine (3TC), and stavudine (d4T) on cell survival and mutagenicity in two reporter genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and thymidine kinase (TK),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a3d2976c3c0be0b87336fa6c1467e9
https://pubmed.ncbi.nlm.nih.gov/17358029

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Interleukin-1-induced NF-kappaB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells

Autor: Michael G. Izban, Melvyn S. Soloff, Randy C. Mifflin, Dennis L. Cook, Yow-Jiun Jeng

Publikováno v: Molecular human reproduction. 12(10)

The myometrial oxytocin receptor (OTR) is highly regulated during pregnancy, reaching maximal concentrations near term. These levels are then abruptly reduced in advanced labour and the post-partum period. Our goal was to examine the molecular basis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d615d72bfaacb0e74f5b76f4548a73af
https://pubmed.ncbi.nlm.nih.gov/16888077

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Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination

Autor: Sherine S.L. Chan, Janine H. Santos, Grace E. Kissling, Abraham Nyska, Kristine L. Witt, William C. Copeland, Julie F. Foley, Bhaskar S. Mandavilli, Bennett Van Houten, Joel N. Meyer, Vernon E. Walker, Consuelo L. McCash, Jack B. Bishop, Dennis L. Cook

Publikováno v: Environmental and molecular mutagenesis. 48(3-4)

Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors (NRTIs), like zidovudine (3′-azido-3′-deoxythymidine; AZT) and lamivudine ((-)2′,3′-dideoxy-3′-thiacytidine; 3TC), markedly reduce mother-to-child transmission of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673da1028a9d1e3b8ee7ec0375a41821
https://pubmed.ncbi.nlm.nih.gov/16395692

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Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene

Autor: Quanxin Meng, Dale M. Walker, Jake D. McDonald, Rogene F. Henderson, Meghan M. Carter, Dennis L. Cook, null Jr., Consuelo L. McCash, Salina M. Torres, Michael J. Bauer, Steven K. Seilkop, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen, James A. Swenberg, Vernon E. Walker

Publikováno v: Chemico-biological interactions. 166(1-3)

Experiments were performed: (i) to investigate potential age- and gender-dependent differences in mutagenic responses in T cells following exposures of B6C3F1 mice and F344 rats by inhalation for 2 weeks to 0 or 1250 ppm butadiene (BD), and (ii) to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96bb9b3bbb738bc0ce451d7c473af21
https://pubmed.ncbi.nlm.nih.gov/16945358

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Persistence of mitochondrial toxicity in hearts of female B6C3F1 mice exposed in utero to 3'-azido-3'-deoxythymidine

Autor: Dale M, Walker, Miriam C, Poirier, Matthew J, Campen, Dennis L, Cook, Rao L, Divi, Kunio, Nagashima, Amie K, Lund, Patsy Y, Cossey, Fletcher F, Hahn, Vernon E, Walker

Publikováno v: Cardiovascular toxicology. 4(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::906f49226e46fa9438fb6320a072e6ef
https://pubmed.ncbi.nlm.nih.gov/15371630

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The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

Autor: Steven A. Belinsky, Christine A. Stidley, Richard E. Crowell, Frank D. Gilliland, Dennis L. Cook, Kevin K. Divine, Thèrése Bocklage

Publikováno v: Mutation research. 461(4)

Defects in the repair and maintenance of DNA increase risk for cancer. X-ray cross-complementing group 1 protein (XRCC1) is involved with the repair of DNA single-strand breaks. A nucleotide substitution of guanine to adenine leading to a non-conserv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08872e608176c0f8088d184e5f8e7018
https://pubmed.ncbi.nlm.nih.gov/11104903

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