Výsledky vyhledávání - "Dennis L Y Dong"

Purification and characterization of an O-GlcNAc selective N-acetyl-beta-D-glucosaminidase from rat spleen cytosol

Publikováno v: Journal of Biological Chemistry. 269:19321-19330

Glycosylation of nuclear and cytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) monosaccharides is an abundant, ubiquitous, and transient post-translational modification. To characterize enzymes involved in removal of these sugars, a neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fbcb497a2428abc4881bf91412160f3
https://doi.org/10.1016/s0021-9258(17)32170-1

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Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M

Autor: Gerald W. Hart, Don W. Cleveland, Dennis L Y Dong, Zuoshang Xu, M. R. Chevrier, Robert J. Cotter

Publikováno v: Journal of Biological Chemistry. 268:16679-16687

Neurofilaments are neuronal intermediate filaments that play an important role in the growth and maintenance of large myelinated axons. Mammalian neurofilaments are composed of three polypeptide subunits, designed as NF-L, NF-M, and NF-H, all of whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12dda0da93f5cf1b7f6e6a6aa7920df2
https://doi.org/10.1016/s0021-9258(19)85471-6

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

Autor: Michael K. Lee, Robert N. Cole, Dennis L Y Dong, C. Shane Arnold, Gerald W. Hart, Gail V.W. Johnson

Publikováno v: The Journal of biological chemistry. 271(46)

Tau is a family of phosphoproteins that are important in modulating microtubule stability in neurons. In Alzheimer's disease tau is abnormally hyperphosphorylated, no longer binds microtubules, and self-assembles to form paired helical filaments that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a28f3c114210dd5809a18988b320be5
https://pubmed.ncbi.nlm.nih.gov/8910513

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Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H

Autor: Gerald W. Hart, Dennis L Y Dong, Zuoshang Xu, Don W. Cleveland

Publikováno v: The Journal of biological chemistry. 271(34)

Neurofilaments, the major intermediate filaments in large myelinated neurons, are essential for specifying proper axonal caliber. Mammalian neurofilaments are obligate heteropolymers assembled from three polypeptides, neurofilament (NF)-H, NF-M, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69741dbbfe3960f88ccca4cb4adac55
https://pubmed.ncbi.nlm.nih.gov/8702840

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Neuronal intermediate filaments: new progress on an old subject

Autor: Zuoshang Xu, Dennis L Y Dong, Don W. Cleveland

Publikováno v: Current opinion in neurobiology. 4(5)

Neurofilaments (NFs) are the major intermediate filaments in most mature neurons. Genetic approaches have now proven that NFs are an essential determinant for radial growth of axons. NF phosphorylation most probably plays an important role in this fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2d7caea15338bd9100cc083012a2b0
https://pubmed.ncbi.nlm.nih.gov/7849521

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