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pro vyhledávání: '"Dennis L Kelleher"'
Autor:
Dennis L Kelleher, Rashmi S Mehta, Bernadette M Jean-Francois, Andrew F Preece, James Blowers, Glenn D Crater, Paul Thomas
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50716 (2012)
Umeclidinium bromide (GSK573719; UMEC), a new long-acting muscarinic receptor antagonist (LAMA), is in development with vilanterol (GW642444; VI), a selective long-acting β(2) agonist (LABA), as a once-daily inhaled combination therapy for the treat
Externí odkaz:
https://doaj.org/article/67a39d40dcd949bb97b27ea55ef4ff4d
Publikováno v:
Pharmacology. 18:180-187
DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirs
Publikováno v:
Journal of Applied Physiology. 47:59-66
Female rats treated chronically with ethynylestradiol (36 micrograms/kg per day) alone, and in combination with the progestational agent, norethynodrel (253 micrograms/kg per day), cooled significantly faster than controls when lightly restrained and
Autor:
Melvin J. Fregly, Dennis L. Kelleher
Publikováno v:
Pharmacology. 35:203-216
Earlier studies have shown that chronic treatment with estradiol benzoate reduced the responsiveness of heart rate, drinking, and tail-skin temperature to administration of the beta-adrenergic agonist, isoproterenol. The objective of the present stud
Publikováno v:
Metabolism. 31:252-257
Glucose turnover was measured in rats subjected to experimental peritonitis. Fifteen hours following cecal ligation and puncture or sham surgery, rats were anesthetized with pentobarbital and glucose metabolism was estimated by constant infusion trac
Autor:
Melvin J. Fregly, Dennis L. Kelleher
Publikováno v:
Appetite. 1:279-289
Acute administration of the β-adrenergic agonist, isoproterenol (25–50μg/kg body weight, subcutaneous), induced drinking and an antidiuresis in rats during the first hour after treatment. Clonidine, administered at doses of 12·5 to 200μg/kg b.w
Publikováno v:
Brain research bulletin. 7(6)
The dipsogenic responses of female rats to administration of angiotensin II (150 micrograms/kg b.w., IP), pilocarpine (3 mg/kg IP), hypertonic saline (1 M NaCl solution, 1% b.w.), and a 24 hour dehydration were attenuated by acute IP administration o
Autor:
Dennis L. Kelleher, Philip Posner
Publikováno v:
Pharmacology. 27(4)
The ability of tetrodotoxin and verapamil to block Ca++-dependent action potentials (CaP) produced in superfused, canine cardiac Purkinje fibers was studied using intracellular microelectrodes. CaP were produced in fibers superfused with a Na+-free (