Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dennis L Guberski"'
Autor:
Christian W Grant, Catherine M Moran-Paul, Shane K Duclos, Dennis L Guberski, Guillermo Arreaza-Rubín, Lisa M Spain
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72989 (2013)
We report the results of an independent laboratory's tests of novel agents to prevent or reverse type 1 diabetes (T1D) in the non-obese diabetic (NOD) mouse, BioBreeding diabetes prone (BBDP) rat, and multiple autoimmune disease prone (MAD) rat model
Externí odkaz:
https://doaj.org/article/d29b419334094765ada84d59fd122149
Autor:
Chaoxing Yang, Agata Jurczyk, Philip diIorio, Elaine Norowski, Michael A Brehm, Christian W Grant, Dennis L Guberski, Dale L Greiner, Rita Bortell
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78050 (2013)
Epidemiologic and clinical evidence suggests that virus infection plays an important role in human type 1 diabetes pathogenesis. We used the virus-inducible BioBreeding Diabetes Resistant (BBDR) rat to investigate the ability of sodium salicylate, a
Externí odkaz:
https://doaj.org/article/10866a00990e4432ba57fc70af044e2e
Autor:
Rebecca S. Tirabassi, Christopher I. Ace, Tatyana Levchenko, Vladimir P. Torchilin, Liisa K. Selin, Siwei Nie, Dennis L. Guberski, Kejian Yang
Publikováno v:
Vaccine. 29:1090-1098
An estimated 1 out of every 5 Americans is infected with herpes simplex virus type 2 (HSV-2). Efforts in developing a potent vaccine for HSV-2 have shown limited success. Here we describe a heterologous vaccination strategy for HSV-2 based on an intr
Autor:
Dennis L. Guberski, Aldo A. Rossini, Dale L. Greiner, Annie J. Kruger, Rita Bortell, Douglas Hinerfeld, John P. Mordes, Karin M. Green, Chaoxing Yang, James E. Evans, Kejian Yang, John D. Leszyk, Sun W. Tam
Publikováno v:
Experimental Biology and Medicine. 235:1328-1337
Proteomic profiling of serum is a powerful technique to identify differentially expressed proteins that can serve as biomarkers predictive of disease onset. In this study, we utilized two-dimensional (2D) gel analysis followed by matrix-assisted-lase
Autor:
Shane K. Duclas, Julia V. Busik, Walter J. Esselman, Nafissa Yakubova, Danny Player, Andrew L. Sochacki, Jennifer L. Kielczewski, Maria B. Grant, Sungjin Kim, Michael E. Boulton, Takahiko Nakagawa, Sergio Li Calzi, Stephanie Hasty, Sergio Caballero, Mark S. Segal, Maria Tikhonenko, Ashay D Bhatwadekar, Madalina Opreanu, Aqeela Afzal, Dennis L. Guberski
Publikováno v:
The Journal of Experimental Medicine
The present epidemic of diabetes is resulting in a worldwide increase in cardiovascular and microvascular complications including retinopathy. Current thinking has focused on local influences in the retina as being responsible for development of this
Autor:
Jean Leif, Rebecca S. Tirabassi, John P. Mordes, Zhijun Liu, Dale L. Greiner, Donald Winans, Elizabeth P. Blankenhorn, Bruce A. Woda, Dennis L. Guberski
Publikováno v:
Diabetes. 59:110-118
OBJECTIVE The contribution of antecedent viral infection to the development of type 1 diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) identify viruses capable of modulating diabetes penetrance, 2) identify
Autor:
Rebecca S. Tirabassi, Dale L. Greiner, Dennis L. Guberski, Joan F. Flanagan, Bruce A. Woda, Jean Leif, Edward H. Kislauskis, John P. Mordes
Publikováno v:
Diabetes. 54:2727-2733
We describe a new rat model of autoimmune diabetes that arose in a major histocompatibility complex congenic LEW rat. Spontaneous diabetes in LEW.1WR1 rats (RT1(u/u/a)) occurs with a cumulative frequency of approximately 2% at a median age of 59 days
Autor:
Tiangen Wu, Dennis L. Guberski, Edward H. Kislauskis, Rebecca S. Tirabassi, Joan F. Flanagan, Paul J Birckbichler
Publikováno v:
ILAR Journal. 45:292-302
Congenic and inbred strains of rats offer researchers invaluable insight into the etiopathogenesis of diabetes and associated complications. The inbred Bio-Breeding Zucker diabetic rat (BBZDR)/Wor rat strain is a relatively new and emerging model of
Publikováno v:
Free Radical Biology and Medicine. 28:91-101
Hyperglycemia in diabetes induces increased levels of hydrogen peroxide (H2O2), a reactive oxygen species generated by reduced nicotinamide adenine dinucleotide (NADH) oxidase. Nontoxic levels of H2O2 increase endothelial cell permeability. Using a m
Autor:
Catherine M. Moran-Paul, Christian Grant, Lisa M. Spain, Shane Duclos, Guillermo Arreaza-Rubin, Dennis L. Guberski
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72989 (2013)
PLoS ONE
PLoS ONE
We report the results of an independent laboratory’s tests of novel agents to prevent or reverse type 1 diabetes (T1D) in the non-obese diabetic (NOD) mouse, BioBreeding diabetes prone (BBDP) rat, and multiple autoimmune disease prone (MAD) rat mod