Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Dennis Löffler"'
Autor:
Michael Rade, Markus Kreuz, Angelika Borkowetz, Ulrich Sommer, Conny Blumert, Susanne Füssel, Catharina Bertram, Dennis Löffler, Dominik J. Otto, Livia A. Wöller, Carolin Schimmelpfennig, Ulrike Köhl, Ann-Cathrin Gottschling, Pia Hönscheid, Gustavo B. Baretton, Manfred Wirth, Christian Thomas, Friedemann Horn, Kristin Reiche
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-20 (2024)
Abstract Background Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously developed the prognostic
Externí odkaz:
https://doaj.org/article/c464d6da04a84fa9b2ebac3773083177
Autor:
Michael Rade, Sebastian Böhlen, Vanessa Neuhaus, Dennis Löffler, Conny Blumert, Maximilian Merz, Ulrike Köhl, Susann Dehmel, Katherina Sewald, Kristin Reiche
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns ov
Externí odkaz:
https://doaj.org/article/ffa3005e33b34cc29a0db10630ff1cf6
Autor:
Carolin Schimmelpfennig, Michael Rade, Susanne Füssel, Dennis Löffler, Conny Blumert, Catharina Bertram, Angelika Borkowetz, Dominik J. Otto, Sven-Holger Puppel, Pia Hönscheid, Ulrich Sommer, Gustavo B. Baretton, Ulrike Köhl, Manfred Wirth, Christian Thomas, Friedemann Horn, Markus Kreuz, Kristin Reiche
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-20 (2023)
Abstract Background Prostate cancer (PCa) is one of the most prevalent cancers worldwide. The clinical manifestations and molecular characteristics of PCa are highly variable. Aggressive types require radical treatment, whereas indolent ones may be s
Externí odkaz:
https://doaj.org/article/33f9e042a8f748879f7f4908f10f205d
Autor:
Johannes R. Schmidt, Janine Haupt, Sina Riemschneider, Christoph Kämpf, Dennis Löffler, Conny Blumert, Kristin Reiche, Ulrike Koehl, Stefan Kalkhof, Jörg Lehmann
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a broad range of target genes involved in the xenobiotic response, cell cycle control and circadian rhythm. AhR is constitutively expressed in m
Externí odkaz:
https://doaj.org/article/50c2080dfa3c40d1835ec887c54f41ce
Autor:
Lia Walcher, Ann-Kathrin Kistenmacher, Charline Sommer, Sebastian Böhlen, Christina Ziemann, Susann Dehmel, Armin Braun, Uta Sandy Tretbar, Stephan Klöß, Axel Schambach, Michael Morgan, Dennis Löffler, Christoph Kämpf, Conny Blumert, Kristin Reiche, Jana Beckmann, Ulla König, Bastian Standfest, Martin Thoma, Gustavo R. Makert, Sebastian Ulbert, Uta Kossatz-Böhlert, Ulrike Köhl, Anna Dünkel, Stephan Fricke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundWith increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient production processes of these “off-the-shelf” therapeutics. In order to ensure safety and pr
Externí odkaz:
https://doaj.org/article/216b146cb0614edf85a6fa9c14d78357
Autor:
Dennis Löffler, Susanne Behrendt, John W.M. Creemers, Jürgen Klammt, Gabriela Aust, Juraj Stanik, Wieland Kiess, Peter Kovacs, Antje Körner
Publikováno v:
Molecular Metabolism, Vol 6, Iss 3, Pp 295-305 (2017)
Objective: Variants in Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) may be causative for obesity as suggested by monogenic cases and association studies. Here we assessed the functional relevance in experimental studies and the clinical rele
Externí odkaz:
https://doaj.org/article/071b460c88ce41049a3b3e9cde0cd903
Autor:
Julia Gesing, Kathrin Scheuermann, Isabel Viola Wagner, Dennis Löffler, Daniela Friebe, Wieland Kiess, Volker Schuster, Antje Körner
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183027 (2017)
Nicotinamide phosphoribosyl transferase (NAMPT) is an inflammatory adipocytokine shown to interact in immune modulation in chronic inflammatory diseases, acute respiratory distress syndrome, sepsis, cancer and obesity in adulthood. It is, however, no
Externí odkaz:
https://doaj.org/article/c5d2747d775a4397bd3ed76ba53df2f4
Autor:
Daniela Friebe, Dennis Löffler, Maria Schönberg, Falk Bernhard, Petra Büttner, Kathrin Landgraf, Wieland Kiess, Antje Körner
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e19526 (2011)
FTO and NAMPT/PBEF/visfatin are thought to play a role in obesity but their transcriptional regulation in adipocytes is not fully understood. In this study, we evaluated the transcriptional regulation of FTO and NAMPT in preadipocytes and adipocytes
Externí odkaz:
https://doaj.org/article/7cd9ce6e0d89479a97c6f60bd536fbaa
Autor:
Armin Braun, Sebastian Böhlen, Martin Thoma, Kristin Reiche, Anna Dünkel, Bastian Standfest, Christina Ziemann, Ulla König, Jana Beckmann, Axel Schambach, Stephan Klöß, Ann-Kathrin Kistenmacher, Charline Sommer, Lia Walcher, Gustavo R. Makert, Dennis Löffler, Christoph Kämpf, Ulrike Köhl, Uta Sandy Tretbar, Stephan Fricke, Michael A. Morgan, Sebastian Ulbert, Uta Kossatz-Böhlert, Susann Dehmel, Conny Blumert
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
BackgroundWith increasing clinical use of NK-92 cells and their CAR-modified derivatives in cancer immunotherapy, there is a growing demand for efficient production processes of these “off-the-shelf” therapeutics. In order to ensure safety and pr
Publikováno v:
Pediatric Obesity. 13:159-167
SummaryBackground The amino acid-changing exonic variant rs6265 (Val66Met polymorphism) in the brain-derived neurotrophic factor (BDNF) has been linked to obesity in several genotype–phenotype association studies. Objective To identify metabolic fa