Zobrazeno 1 - 10
of 401
pro vyhledávání: '"Dennis L, Kasper"'
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1913-1921 (2023)
Abstract Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the intestines. Over decades, numerous studies have shown that our mucosal immune system is
Externí odkaz:
https://doaj.org/article/f3e2f9050e2e4626b69648f9146c0cb8
Autor:
Bin Bao, Youyuan Wang, Pavl Boudreau, Xinyang Song, Meng Wu, Xi Chen, Izabel Patik, Ying Tang, Jodie Ouahed, Amit Ringel, Jared Barends, Chuan Wu, Emily Balskus, Jay Thiagarajah, Jian Liu, Michael R. Wessels, Wayne Isaac Lencer, Dennis L. Kasper, Dingding An, Bruce Harold Horwitz, Scott B. Snapper
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 2, Pp 101350- (2024)
Background & Aims: Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells. P
Externí odkaz:
https://doaj.org/article/ebe59fd22bdd4d17a31e6bcf11e820ec
Autor:
Da-Jung Jung, Ledia Gebremedhin, Byoungsook Goh, Ji-Sun Yoo, Francesca Gazzaniga, Dennis L. Kasper, Sungwhan F. Oh
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTSymbiotic microbiota critically contribute to host immune homeostasis in effector cell-specific manner. For exclusion of microbial component, germ-free animals have been the gold standard method. However, total removal of the entire gut micro
Externí odkaz:
https://doaj.org/article/59d91c334bf4416cac5a3b7b2ee3657b
Autor:
Joon Seok Park, Francesca S. Gazzaniga, Meng Wu, Amalia K. Luthens, Jacob Gillis, Wen Zheng, Martin W. LaFleur, Sarah B. Johnson, Golnaz Morad, Elizabeth M. Park, Yifan Zhou, Stephanie S. Watowich, Jennifer A. Wargo, Gordon J. Freeman, Dennis L. Kasper, Arlene H. Sharpe
Publikováno v:
Nature. 617:377-385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e299b71b22fb01c8deb807cf531941d
https://doi.org/10.1038/s41586-023-06026-3
https://doi.org/10.1038/s41586-023-06026-3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The symbiotic relationship between animals and their resident microorganisms has profound effects on host immunity. The human microbiota comprises bacteria that reside in the gastrointestinal tract and are involved in a range of inflammatory and auto
Externí odkaz:
https://doaj.org/article/8c024cf5c7b547999e895228a9df68f1
Autor:
Francesca S. Gazzaniga, Diogo M. Camacho, Meng Wu, Matheus F. Silva Palazzo, Alexandre L. M. Dinis, Francis N. Grafton, Mark J. Cartwright, Michael Super, Dennis L. Kasper, Donald E. Ingber
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Commensal bacteria within the gut microbiome contribute to development of host tolerance to infection, however, identifying specific microbes responsible for this response is difficult. Here we describe methods for developing microfluidic organ-on-a-
Externí odkaz:
https://doaj.org/article/9ffde592c4ba44639118bbf21a8d7e1e
Autor:
Giuseppe Stefanetti, Dennis L. Kasper
Publikováno v:
Biochemistry. 61:2849-2855
Vaccination shows high variability in the elicited immune responses among individuals and populations for reasons still poorly understood. An increasing number of studies is supporting the evidence that gut microbiota, along with other interplaying v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f8acd4e1fa90d8d462fecdced06dea
https://doi.org/10.1021/acs.biochem.2c00309
https://doi.org/10.1021/acs.biochem.2c00309
Autor:
Ji-Sun Yoo, Byoungsook Goh, Kyoo Heo, Da-Jung Jung, Wen Zheng, ChangWon C. Lee, Naama Geva-Zatorsky, Meng Wu, Seung Bum Park, Dennis L. Kasper, Sungwhan F. Oh
Publikováno v:
bioRxiv
SummaryBioactive metabolites produced by symbiotic microbiota causally impact host health and disease, nonetheless, incomplete functional annotation of genes as well as complexities and dynamic nature of microbiota make understanding species-level co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a8aae072451a24a5f61c84bdf68665
https://europepmc.org/articles/PMC10245877/
https://europepmc.org/articles/PMC10245877/
Autor:
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C. Macbeth, Elyza A. Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S. Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M. Chiu, Jeffrey R. Moffitt, Ansel Hsiao, John J. Mekalanos, Christophe Benoist, Dennis L. Kasper
Publikováno v:
bioRxiv
Canonically, complement is a serum-based host defense system that protects against systemic microbial invasion. Little is known about the production and function of complement components on mucosal surfaces. Here we show gut complement component 3 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e123493ed381fc22f2f57e2ae0c488
https://europepmc.org/articles/PMC9915568/
https://europepmc.org/articles/PMC9915568/
Autor:
Da-Jung Jung, Jérôme Le Nours, Dennis L. Kasper, Jesang Lee, ChangWon C. Lee, Hyun-Soo Kim, Seung Bum Park, Yoon Soo Hwang, Deniz Erturk-Hasdemir, Jamie Rossjohn, Ji-Sun Yoo, Heebum Song, T. Praveena, Sungwhan F. Oh, Richard S. Blumberg
Publikováno v:
Nature
Small molecules derived from symbiotic microbiota critically contribute to intestinal immune maturation and regulation1. However, little is known about the molecular mechanisms that control immune development in the host–microbiota environment. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08107eb64087645ec0f9e1590f0ab439
https://doi.org/10.1038/s41586-021-04083-0
https://doi.org/10.1038/s41586-021-04083-0