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pro vyhledávání: '"Dennis Kyle Neeld"'
Publikováno v:
The Journal of Immunology. 206:53.06-53.06
Programed Cell death (PD-1), encoded by Pdcd1, is an immune inhibitory receptor expressed on the surface of lymphocytes. Surface PD-1 expression is amongst its highest in a subset of CD4+ T cells called T follicular helper cells (TFH). TFH cells are
Autor:
Dennis Kyle Neeld, Alexander Bally, Peiyuan Lu, Parimal Majumder, Benjamin Barwick, Jeremy M Boss
Publikováno v:
The Journal of Immunology. 202:60.13-60.13
Prolonged exposure to antigen, such as during chronic viral infections and cancer, leads to sustained TCR signaling and ultimately T cell exhaustion, which is in part mediated by up regulation of Programmed cell death 1 (PD-1). Antibody blockade of P
Publikováno v:
The Journal of Immunology. 196:134.14-134.14
Due to its impact on global health, gaining insight into the immune mechanisms that control Plasmodium infections and specifically the complications associated with cerebral malaria are key for developing appropriate therapeutics. For Plasmodium berg