Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Dennis Keefe"'
Autor:
Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka-Kuka, Aksu Günay, Nuran Koçak, Izaak R. Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A. Zariwala, P. Hande Özdinler
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106022- (2023)
Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most commonly observed proteinopathy. Disrupted inner mito
Externí odkaz:
https://doaj.org/article/500a9a36e006467bbaa75e89a1dedef4
Autor:
Jennifer Bosco, Zhiwei Zhou, Sofie Gabriëls, Mayank Verma, Nan Liu, Brian K. Miller, Sheng Gu, Dianna M. Lundberg, Yan Huang, Eilish Brown, Serene Josiah, Muthuraman Meiyappan, Matthew J. Traylor, Nancy Chen, Atsushi Asakura, Natalie De Jonge, Christophe Blanchetot, Hans de Haard, Heather S. Duffy, Dennis Keefe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 369-381 (2021)
Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which is exacerbated by localized functional ischemia due to loss of nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing vascular perf
Externí odkaz:
https://doaj.org/article/7cd6bc0f05504665be33e9a95fc823af
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features o
Externí odkaz:
https://doaj.org/article/a0a3bdfe79184dedbcc355b0d9ece19c
Autor:
Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James P Ennen, Jennifer Bosco, Zhiwei Zhou, Guo-Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008468 (2019)
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease in which the dystrophin coding for a membrane stabilizing protein is mutated. Recently, the vasculature has also shown to be perturbed in DMD and DMD model mdx mice. Recent DM
Externí odkaz:
https://doaj.org/article/e43f9db685584f0ead194a9b1ef89670
Autor:
Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka-Kuka, Aksu Günay, Nuran Koçak, Izaak R. Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A. Zariwala, P. Hande Özdinler
Mitochondrial defects are one of the common underlying causes of neuronal vulnerability in motor neuron diseases, such as amyotrophic lateral sclerosis (ALS), and TDP-43 pathology is the most common proteinopathy in ALS. Disrupted inner mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3353495380527735ee054cd2e13b0ce6
https://doi.org/10.1101/2022.10.04.510854
https://doi.org/10.1101/2022.10.04.510854
Autor:
Brian K. Miller, Sofie Gabriels, Nan Liu, Hans de Haard, Dennis Keefe, Mayank Verma, Christophe Blanchetot, Muthuraman Meiyappan, Dianna Lundberg, Serene Josiah, Matthew J. Traylor, Atsushi Asakura, Sheng Gu, Yan Huang, Chen Nancy, Heather S. Duffy, Jennifer Bosco, Natalie De Jonge, Eilish Brown, Zhiwei Zhou
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 369-381 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 369-381 (2021)
Duchenne muscular dystrophy is characterized by structural degeneration of muscle, which is exacerbated by localized functional ischemia due to loss of nitric oxide synthase-induced vasodilation. Treatment strategies aimed at increasing vascular perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d3ca264bd99a2f18656a7d7231a8a1
https://doi.org/10.1016/j.omtm.2021.03.013
https://doi.org/10.1016/j.omtm.2021.03.013
Autor:
Kurt H. Albertine, Mar Janna Dahl, Andrew Rebentisch, Elaine Dawson, Akbar Nabi, Sydney Bowen, Cindy Miers, Zhengming Wang, Haixia Yang, Baifeng Yu, Donald M. Null, Dennis Keefe, J.-K. Chung, Z. Zhou, Norman Barton, Galen Carey, Robert Ward
Publikováno v:
Pediatric research.
Low levels of insulin-like growth factor-1 (IGF-1) protein in preterm human infants are associated with bronchopulmonary dysplasia (BPD). We used our preterm lamb model of BPD to determine (1) dosage of recombinant human (rh) IGF-1 bound to binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aae6a2bcbf55155ec7c5c4b9d0feb1
https://pubmed.ncbi.nlm.nih.gov/36030318
https://pubmed.ncbi.nlm.nih.gov/36030318
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Objective Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features of this pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4af6c2b33b3bbc0d549b091141f275
https://doi.org/10.1186/s13104-021-05613-9
https://doi.org/10.1186/s13104-021-05613-9
Objective: Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features of this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f95f8654fe0f244d1ca0b5e0d044b7c
https://doi.org/10.21203/rs.3.rs-405663/v1
https://doi.org/10.21203/rs.3.rs-405663/v1
Autor:
Dennis Keefe, Guo-Hua Fong, Zhiwei Zhou, Mayank Verma, Atsushi Asakura, Jennifer Bosco, Yoko Asakura, Serene Josiah, Yuko Shimizu-Motohashi, James P. Ennen
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008468 (2019)
PLoS Genetics
PLoS Genetics
Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic disease in which the dystrophin coding for a membrane stabilizing protein is mutated. Recently, the vasculature has also shown to be perturbed in DMD and DMD model mdx mice. Recent DM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142bc6ed8fd41a53073e8e93e3a1635e
https://doaj.org/article/e43f9db685584f0ead194a9b1ef89670
https://doaj.org/article/e43f9db685584f0ead194a9b1ef89670