Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dennis K.J. Gorecki"'
Autor:
Dennis K.J. Gorecki, Armando Varela-Ramirez, Umashankar Das, Erik De Clercq, Carolina Lema, Jan Balzarini, Renato J. Aguilera, Nora M. Ortega, Swagatika Das, Jonathan R. Dimmock, Yahaira Santiago-Vazquez, Stephen G. Dimmock, Elisa Robles-Escajeda
Publikováno v:
European Journal of Medicinal Chemistry. 77:315-322
Novel clusters of 3,5-bis(benzylidene)-4-oxo-1-piperidinyl dimers 3–5 were evaluated against human Molt4/C8 and CEM T-lymphocytes and human HeLa cervix adenocarcinoma cells as well as murine L1210 leukemia neoplasms. Several of these compounds demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2876923402c46df79b2705280ea5f97a
https://doi.org/10.1016/j.ejmech.2014.03.009
https://doi.org/10.1016/j.ejmech.2014.03.009
Autor:
Louis R. Cantilena, Dennis K.J. Gorecki, Mei Chung, Robert R. Wolfe, Robert E. Osterberg, Nandakumara D. Sarma, Luis G. Valerio, Johanna T. Dwyer, Scott A. Jordan, Patricia A. Deuster, Robin J. Marles, Tieraona Low Dog, Mary L. Hardy, Marilyn L. Barrett, Bruce E. Rodda, James R. Brooks, Gabriel I. Giancaspro, Hellen Oketch-Rabah, Ronald J. Maughan, Jorge M. Zuniga, Donnamaria Jones, Rebecca B. Costello
Publikováno v:
Nutrition reviews. 74(11)
Context: Dietary supplements are widely used by military personnel and civilians for promotion of health. Objective: The objective of this evidence-based review was to examine whether supplementation with l-arginine, in combination with caffeine and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c210be28499ae59b4f1d548d0eb389
https://pubmed.ncbi.nlm.nih.gov/27753625
https://pubmed.ncbi.nlm.nih.gov/27753625
Autor:
Shoko Iwamoto, Tomohiko Matsuta, Umashankar Das, Dennis K.J. Gorecki, Swagatika Das, Jonathan R. Dimmock, Julianna Serly, Naoki Umemura, Masami Kawase, Hiroshi Sakagami, Joseph Molnár
Publikováno v:
European Journal of Medicinal Chemistry. 51:193-199
A series of bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides 1 display potent cytotoxic properties towards a wide range of tumours. A number of the CC 50 and IC 50 values are in the range of 10 −8 M. Specifically, these compounds have the follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001d18f4f4bbeafe1b6d7fc2454dd350
https://doi.org/10.1016/j.ejmech.2012.02.042
https://doi.org/10.1016/j.ejmech.2012.02.042
Autor:
Jan Balzarini, Dennis K.J. Gorecki, Erik De Clercq, Joseph Molnár, Ponniah Selvakumar, Swagatika Das, Umashankar Das, Rajendra K. Sharma, Brian Bandy, Jonathan R. Dimmock, Zoltán Baráth, Gabriele Schatte, Julianna Serly
Publikováno v:
ChemMedChem. 4:1831-1840
A series of 3,5-bis(benzylidene)-4-piperidones 3 were converted into the corresponding 3,5-bis(benzylidene)-1-phosphono-4-piperidones 5 via diethyl esters 4. The analogues in series 4 and 5 displayed marked growth inhibitory properties toward human M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb06af8151573ddbf5a86bbf547c69b
https://doi.org/10.1002/cmdc.200900288
https://doi.org/10.1002/cmdc.200900288
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 85:1184-1194
Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2asubclass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53bcd706ba86ff939c5a9eef8c5df928
https://doi.org/10.1139/y07-109
https://doi.org/10.1139/y07-109
Publikováno v:
Journal of Wildlife Diseases. 36:653-662
A pharmacokinetic and tissue residue study was conducted to assess the risks asso- ciated with human consumption of polar bears in arctic Canada that have been exposed to the immobilizing drug Telazolt, a mixture of tiletamine hydrochloride and zolaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5662ba305c05f8710f8f65d115c9ac69
https://doi.org/10.7589/0090-3558-36.4.653
https://doi.org/10.7589/0090-3558-36.4.653
Autor:
Phyllis G. Paterson, Katherine Gottschall-Pass, Dennis K.J. Gorecki, Hugh Semple, Bruce H. Grahn
Publikováno v:
Nutritional Neuroscience. 2:175-189
The study objective was to evaluate the retinal response to deficiencies of zinc and taurine present throughout the period of postnatal retinal development. At parturition, Sprague-Dawley dams were assigned to one of four treatments in a 2 × 2 facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3237c21fb8bb0e1344ca8695d8789381
https://doi.org/10.1080/1028415x.1999.11747276
https://doi.org/10.1080/1028415x.1999.11747276
Autor:
Katherine T. Gottschall-Pass, Hugh Semple, Bruce H. Grahn, Dennis K.J. Gorecki, Phyllis G. Paterson
Publikováno v:
The Journal of Nutritional Biochemistry. 9:621-628
The objective of this study was to investigate whether zinc interacts with taurine to influence the development of the electroretinogram. Virgin female Sprague-Dawley rats were bred overnight and assigned to 1 of 4 treatments in a 2 × 2 factorial de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6edda73c7b6e01b7fda725f202d287d7
https://doi.org/10.1016/s0955-2863(98)00063-1
https://doi.org/10.1016/s0955-2863(98)00063-1
Publikováno v:
European journal of medicinal chemistry. 64
Two novel series of dimeric 3,5-bis(arylidene)-4-piperidones 7 and 8 were prepared as cytotoxic agents. A specific objective of this study was the discovery of novel compounds displaying potent anti-proliferative activities against colon cancers. Mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f131592f229480ebbc7db0324558b3c0
https://pubmed.ncbi.nlm.nih.gov/23644215
https://pubmed.ncbi.nlm.nih.gov/23644215
Publikováno v:
The Journal of Nutritional Biochemistry. 5:298-302
It has been suggested that erythrocyte deformability is decreased in vitamin E deficiency due to oxidative damage to the cell membrane. Male Wistar rats (66 to 88 g) were fed ad libitum an AIN76-based diet containing tocopherol-stripped corn oil with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad1e1a0679b3c54d8bb2aa20f66df545
https://doi.org/10.1016/0955-2863(94)90035-3
https://doi.org/10.1016/0955-2863(94)90035-3