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pro vyhledávání: '"Dennis K. Reschke"'
Autor:
Angelika Longacre, Dennis K. Reschke, Barbara E. Wright, Karen H. Schmidt, Jacqueline M. Reimers
Publikováno v:
Microbiology. 150:1457-1466
Escherichia coliauxotrophs ofleuBandargHwere examined to determine if higher rates of transcription in derepressed genes were correlated with increased reversion rates. Rates ofleuBandargHmRNA synthesis were determined using half-lives and concentrat
Autor:
William Knight, Karen H. Schmidt, Barbara E. Wright, Jacqueline M. Reimers, Dennis K. Reschke
Publikováno v:
Molecular Microbiology. 48:429-441
Summary This work provides evidence that, during transcription, the mutability (propensity to mutate) of a base in a DNA secondary structure depends both on the stability of the structure and on the extent to which the base is unpaired. Zuker ' s DNA
The VH5 human antibody gene was analyzed using a computer program (mfg) which simulates transcription, to better understand transcription-driven mutagenesis events that occur during “phase 1” of somatic hypermutation. Results show that the great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed016aa7b900244f8b6cb350416b097
https://europepmc.org/articles/PMC3235918/
https://europepmc.org/articles/PMC3235918/
Autor:
Aaron T. Hunt, Dennis K. Reschke, Karen H. Schmidt, Michael F. Minnick, J. Stephen Lodmell, Barbara E. Wright
Publikováno v:
Carcinogenesis. 32(10)
Transcription drives supercoiling which forms and stabilizes single-stranded (ss) DNA secondary structures with loops exposing G and C bases that are intrinsically mutable and vulnerable to non-enzymatic hydrolytic reactions. Since many studies in pr
Autor:
Barbara E, Wright, Dennis K, Reschke, Karen H, Schmidt, Jacqueline M, Reimers, William, Knight
Publikováno v:
Molecular microbiology. 48(2)
This work provides evidence that, during transcription, the mutability (propensity to mutate) of a base in a DNA secondary structure depends both on the stability of the structure and on the extent to which the base is unpaired. Zuker's DNA folding c
Publikováno v:
Cancer research. 62(20)
A DNA folding analysis indicates that the most hypermutable bases in exons 5, 7, and 8 of the p53 tumor suppressor gene are located immediately next to stems in stable DNA stem-loop structures. On the basis of the highest negative energy (-DeltaG) va