Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dennis J. Stalker"'
Publikováno v:
Clinical Therapeutics. 38:1778-1788
Purpose The purpose of this study was to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) equivalence of single 100 U/kg subcutaneous doses of Epoetin Hospira and Epogen in healthy male subjects as part of an overall program to demonstrate
Autor:
Dennis J Stalker, Susan Reid, Seema Kumbhat, Nancy E. Martin, Jeffrey Zhang, Atulkumar Ramaiya
Publikováno v:
Clinical therapeutics. 38(5)
Purpose The purpose of this study was to evaluate the pharmacodynamic (PD) and pharmacokinetic (PK) equivalences of multiple doses of the proposed biosimilar Epoetin Hospira to the reference product Epogen ⁎ ⁎Epogen ® (epoetin alfa; Amgen, Thous
Autor:
Gail L. Jungbluth, Michael E. Brier, Donald H. Batts, Margaret O'Grady, Nancy K. Hopkins, Dennis J. Stalker, George R. Aronoff, Kristi K. Ryan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:2775-2780
Linezolid is a member of a new, unique class of synthetic antibacterial agents called oxazolidinones that are effective against gram-positive bacteria, including vancomycin-resistant organisms. We tested the hypothesis that the linezolid clearance wo
Publikováno v:
Biopharmaceutics & Drug Disposition. 22:91-97
Linezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram-positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following
Autor:
Thomas D. Williams, Michael Jay, Hans-Joachim Lehmler, Paul M. Bummer, Dennis J. Stalker, Michael Clark
Publikováno v:
Journal of Pharmaceutical Sciences. 87:1585-1589
Perfluorinated solvents are gaining popularity as pulmonary ventilation fluids, but they suffer from poor solvent quality in concurrent drug delivery applications. The present study examines the use of a hydrophobic solubilizing agent capable of inte
Autor:
Rebecca S. Sloan, Michael E. Brier, George R. Aronoff, Ian R. Welshman, Dennis J. Stalker, Harold Bays
Publikováno v:
American Journal of Kidney Diseases. 29:907-911
To test the hypothesis that renal failure has no effect on the pharmacokinetics of glyburide, five subjects with non-insulin-dependent diabetes mellitus (NIDDM) and end-stage renal disease requiring hemodialysis, and four NIDDM subjects with normal r
Publikováno v:
International Journal of Pharmaceutics. 131:243-246
A modification of an X-ray fluorescence (XRF) technique that could be applied to the noninvasive measurement of transdermal absorption in human subjects with a low absorbed radiation dose was investigated. Secondary X-rays that were produced in a sam
Publikováno v:
Journal of Controlled Release. 34:167-173
The feasibility of using radioisotope-induced X-ray fluorescence (XRF) as a noninvasive method to measure the release rate of peptides/proteins from hydrogels or other formulations in vivo following subcutaneous administration has been demonstrated.
Publikováno v:
Pharmaceutical Research. :1410-1414
X-ray fluorescence (XRF) has been used to determine in vivo the percutaneous absorption of 5-iodouracil (5IU) in dimethyl sulfoxide (DMSO) on female Sprague-Dawley rats. An average absorption rate constant of 122 ± 34 µg/cm2-hr was obtained from th
Publikováno v:
Clinical therapeutics. 31(7)
Background: Conivaptan is a nonpeptide vasopressin V 1A /V 2 -receptor antagonist that produces a controlled increase in serum sodium concentration in hospitalized patients with euvolemic or hyper-volemic hyponatremia. Objective: This study evaluated