Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Dennis J. McCarthy"'
Autor:
Katarina Varnäs, Christer Halldin, Lars Farde, Svante Nyberg, Per Stenkrona, Alan J. Cross, Aurelija Jucaite, Zsolt Cselényi, Jaakko Lappalainen, Chi-Ming Lee, Dennis J. McCarthy
Publikováno v:
Psychopharmacology
Rationale Sedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABAA) receptor positive modulators for the treatment of anxiety. AZD7325 and AZD6280 are novel, subtype-selective GABAAα2,3 receptor positive m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d411ef282db4516a9e40553c8031ef5c
https://doi.org/10.1007/s00213-016-4506-4
https://doi.org/10.1007/s00213-016-4506-4
Autor:
Michele Filosi, Robert Alexander, Enrico Domenici, Susan Marie Learned, Bruno Delafont, Lucia Carboni, Elena Ivanchenko, Emiliangelo Ratti, Dennis J. McCarthy
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019)
Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019)
The identification of biomarkers of response might speed drug development and set the premises to assist clinical practice in psychiatry. In this work, we evaluated a panel of peripheral biomarkers (including IL-6, IL-10, TNF-α, TNFRII, BDNF, CRP, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c2c39a449671eef69e9b39fc473049
https://doi.org/10.1038/s41398-019-0521-7
https://doi.org/10.1038/s41398-019-0521-7
Autor:
Yuchuan Wang, Robert F. Dannals, Holmquist Christopher, J. Richard Heys, Daniel P. Holt, Eifion Phillips, Ronnie C. Mease, Catherine A. Foss, Hayden T. Ravert, Martin G. Pomper, Hong Fan, Christopher J. Endres, Peter N. Dorff, Dennis J. McCarthy
Publikováno v:
Nuclear Medicine and Biology. 40:731-739
Introduction The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is key in brain communication and has been implicated in the pathophysiology of diseases of the central nervous system. A positron-emitting radioligand targeting the α7 nAChR woul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea704c3afc7cb2fd7c266a81d90c973a
https://doi.org/10.1016/j.nucmedbio.2013.04.005
https://doi.org/10.1016/j.nucmedbio.2013.04.005
Autor:
J.F. William Deakin, Steve R. Williams, Gerard R. Dawson, Arpan Dutta, Shane McKie, Kevin J. Craig, Darragh Downey, Mark A. Smith, Guy M. Goodwin, Catherine J. Harmer, Colin T. Dourish, Dennis J. McCarthy
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 26(6)
Intravenous infusion of lanicemine (formerly AZD6765), a low trapping non-selective N-methyl-D-aspartate (NMDA) receptor antagonist, induces antidepressant effects with a similar time course to ketamine. We investigated whether a single dose lanicemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af983ca8c65ed305da32d1723c491cb
http://ora.ox.ac.uk/objects/uuid:5d19dc30-fc02-4e8d-807c-1cb8e1c4be47
http://ora.ox.ac.uk/objects/uuid:5d19dc30-fc02-4e8d-807c-1cb8e1c4be47
Autor:
Robert C. Alexander, Chi-Ming Lee, Mark A. Smith, Dennis J. McCarthy, Sanjeev Pathak, Gerard Sanacora, Stephen J. Kanes
Publikováno v:
Medical Hypotheses. 78:675-681
We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94da1bf381aeb0a05db06aa85f5de6fb
https://doi.org/10.1016/j.mehy.2012.02.009
https://doi.org/10.1016/j.mehy.2012.02.009
Autor:
Michael W. Wood, Dean G. Brown, Shephali Trivedi, Don Mathisen, Mark Sylvester, Xia Wang, John C. Roberts, Zuozhong Peng, Tao Hu, Tiffany N. Hoerter, Magnus Johansson, Donna L. Maier, Tongming Chen, Jennifer R. Krumrine, Ji Jiang, Carla Maciag, Lee T. Hirata, Celina C. Lasota, Anshul Gupta, Deidre E. Wilkins, Frank Liu, Jian Xia, Charles S. Elmore, Evelynjeane J. Sutton, Xiaoping Wang, James B. Campbell, Jerry Cumberledge, Cristobal Alhambra, Dennis J. McCarthy, Elnaz Menhaji-Klotz, Jian Wang, Xiaotian Wen, Paul J. Ciaccio, Clay W Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3399-3403
Herein we describe the discovery of compounds that are competitive antagonists of the CP101-606 binding site within the NR2B subtype of the NMDA receptor. The compounds identified do not possess phenolic functional groups such as those in ifenprodil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e7b2fa51a028f86ba5dd6fd91511b
https://doi.org/10.1016/j.bmcl.2011.03.117
https://doi.org/10.1016/j.bmcl.2011.03.117
Autor:
Katarina Varnäs, Svante Nyberg, Minli Zhang, Christer Halldin, Matts Kågedal, Lars Farde, Zsolt Cselényi, M. Edward Pierson, Dennis J. McCarthy, Alan Xiao, Per Karlsson
Publikováno v:
Psychopharmacology. 213:533-545
The serotonin 5-HT1B receptor is a potential target for the pharmacologic treatment of depression. Positron emission tomography (PET) determination of 5-HT1B receptor occupancy with drug candidates targeting this receptor in non-human primate and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693b581a1df3a2fbd6384d2b16785480
https://doi.org/10.1007/s00213-011-2165-z
https://doi.org/10.1007/s00213-011-2165-z
Autor:
Khanh Bui, James Empfield, Cindy Shen, Luciana Pelosi-Kilby, Yun W. Alelyunas, Dennis J. McCarthy, Russell C. Spreen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7312-7316
We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven drugs had solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d09dd28ced1f27437c6937651057aa
https://doi.org/10.1016/j.bmcl.2010.10.068
https://doi.org/10.1016/j.bmcl.2010.10.068
Autor:
Svante Nyberg, Dennis J. McCarthy, Lars Farde, Jan Andersson, Christer Halldin, Andrea Varrone, Mark A. Smith, Johan Söderström, Per Karlsson, M. Edward Pierson, Akihiro Takano, Katarina Varnäs
Publikováno v:
Journal of cerebral blood flow and metabolism 1 (2011): 113–123.
info:cnr-pdr/source/autori:Varnas Katarina; Nyberg Svante; Halldin Christer; Varrone Andrea; Takano Akihiro; Karlsson Per; Andersson Jan; McCarthy Dennis; Smith Mark; Pierson M. Edward; Soderstrom Johan; Farde Lars/titolo:Quantitative analysis of [(11)C]AZ10419369 binding to 5-HT(1B) receptors in human brain/doi:/rivista:Journal of cerebral blood flow and metabolism/anno:2011/pagina_da:113/pagina_a:123/intervallo_pagine:113–123/volume:1
info:cnr-pdr/source/autori:Varnas Katarina; Nyberg Svante; Halldin Christer; Varrone Andrea; Takano Akihiro; Karlsson Per; Andersson Jan; McCarthy Dennis; Smith Mark; Pierson M. Edward; Soderstrom Johan; Farde Lars/titolo:Quantitative analysis of [(11)C]AZ10419369 binding to 5-HT(1B) receptors in human brain/doi:/rivista:Journal of cerebral blood flow and metabolism/anno:2011/pagina_da:113/pagina_a:123/intervallo_pagine:113–123/volume:1
A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT1B receptors, [11C]AZ10419369, has been recently described. In this study, the potential for quantitative analysis of [11C]AZ10419369 binding to central 5-HT1B recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729e7401a254a21e61b454905a790353
https://doi.org/10.1038/jcbfm.2010.55
https://doi.org/10.1038/jcbfm.2010.55
Publikováno v:
International Oil Spill Conference Proceedings. 2001:1431-1434
This paper explores the challenges involved with the recovery of oil from a discharge canal with limited access and high relative currents. In March 1999, a sheen was observed in the cooling water discharge canal of Consolidated Edison's 2.5-million
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9391a4de9bf1bfef8070e99c10303f92
https://doi.org/10.7901/2169-3358-2001-2-1431
https://doi.org/10.7901/2169-3358-2001-2-1431