Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dennis J. Chia"'
Autor:
Ranjit V. Shenoy, Dorothee Newbern, David W. Cooke, Dennis J. Chia, Leonidas Panagiotakopoulos, Sara DiVall, Lournaris Torres-Santiago, Sitaram Vangala, Nidhi Gupta
Publikováno v:
Academic pediatrics. 22(7)
A structured oral exam (SOE) can be utilized as a formative assessment to provide high-quality formative feedback to trainees, but has not been adequately studied in graduate medical education. We obtained fellow and faculty perspectives on: 1) educa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75cff9029bab015c1a69fd71ba4ef10
https://pubmed.ncbi.nlm.nih.gov/34999252
https://pubmed.ncbi.nlm.nih.gov/34999252
Autor:
Rachel A. Annunziato, Mabel Yau, Elizabeth Chacko, Molly O. Regelmann, Dennis J. Chia, Robert Rapaport, Elizabeth Wallach
Publikováno v:
Hormone Research in Paediatrics. 92:36-44
Background/Aims: Studies are lacking regarding the timing of peak growth hormone (PGH) response. We aim to elucidate the timing of PGH response to arginine and levodopa (A-LD) and evaluate the influence of body mass index (BMI) and other metabolic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb382ebe3464ec54d5efd63f9cceeff
https://doi.org/10.1159/000502308
https://doi.org/10.1159/000502308
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50278 (2012)
Many of the biological effects of growth hormone (GH) are mediated by insulin-like growth factor I (IGF-I), a 70-amino acid secreted peptide whose gene expression is rapidly induced by GH via the Stat5b transcription factor. We previously identified
Externí odkaz:
https://doaj.org/article/c4340d7a6b254a5191ec974022744770
Autor:
Dennis J. Chia
Publikováno v:
Molecular Endocrinology. 28:1012-1025
GH exerts a diverse array of physiological actions that include prominent roles in growth and metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects by influencing gene expression profiles, and Igf1 is a key tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b486213ae8bf42e2ce023919e1252
https://doi.org/10.1210/me.2014-1099
https://doi.org/10.1210/me.2014-1099
Autor:
Mahalakshmi Santhanam, Dennis J. Chia
Publikováno v:
Molecular Endocrinology. 27:2080-2092
The diverse roles of IGF-1 in physiology include acting as the endocrine intermediate to elicit the anabolic actions of GH. The majority of serum IGF-1 is synthesized in liver, where GH stimulates Igf1 gene transcription via the transcription factor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ed3ed3dea67285741af0d43916f988
https://doi.org/10.1210/me.2013-1181
https://doi.org/10.1210/me.2013-1181
Autor:
Dennis J. Chia, Peter Rotwein
Publikováno v:
Molecular Endocrinology. 24:2038-2049
Many of the long-term physiological effects of GH require hormone-mediated changes in gene expression. The transcription factor signal transducer and activator of transcription 5b (Stat5b) plays a critical role in the actions of GH on growth and meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b0c77ff3f5e7d7135c5a4bcddf37c1
https://doi.org/10.1210/me.2010-0234
https://doi.org/10.1210/me.2010-0234
Publikováno v:
Journal of Biological Chemistry. 285:17636-17647
The growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis regulates somatic growth during childhood and orchestrates tissue repair throughout the life span. Recently described inactivating mutations in Stat5b in humans with impaired growth ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9cf770093967ca85f01fac9102c840
https://doi.org/10.1074/jbc.m110.117697
https://doi.org/10.1074/jbc.m110.117697
Autor:
Roxana Merino, Leandro Fernández-Pérez, Oscar M. Vidal, Gunnar Norstedt, Elizabeth Rico-Bautista, Peter Rotwein, Boris Lenhard, Amilcar Flores-Morales, Dennis J. Chia, Joachim Woelfle, Mitsuru Ono
Publikováno v:
Molecular Endocrinology. 21:293-311
The GH-activated signal transducer and activator of transcription 5b (STAT5b) is an essential regulator of somatic growth. The transcriptional response to STAT5b in liver is poorly understood. We have combined microarray-based expression profiling an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685273374072d98d8fc42f2e18071147
https://doi.org/10.1210/me.2006-0096
https://doi.org/10.1210/me.2006-0096
Autor:
Vivian Hwa, William R. Skach, Teresa M. Buck, Ron G. Rosenfeld, Peter Rotwein, Ezhilkani Subbian, Ujwal Shinde, Dennis J. Chia
Publikováno v:
Journal of Biological Chemistry. 281:6552-6558
A predicted alanine to proline substitution in Stat5b that results in profound short stature, growth hormone insensitivity, and immunodeficiency represents the first natural mutation of this transcription factor in a human. To understand the mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7909f36d67e52a2cdb79c90569a005
https://doi.org/10.1074/jbc.m510903200
https://doi.org/10.1074/jbc.m510903200
Autor:
Mylynda Schlesinger-Massart, Mitsuru Ono, Dennis J. Chia, Peter Rotwein, Honglin Jiang, Joachim Woelfle
Publikováno v:
Journal of Biological Chemistry. 281:3190-3197
A key agent in the anabolic actions of growth hormone (GH) is insulin-like growth factor-I (IGF-I), a 70-amino acid secreted protein with direct effects on somatic growth and tissue maintenance and repair. GH rapidly and potently stimulates IGF-I gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8962d4082228b501215ea3d80339b1bc
https://doi.org/10.1074/jbc.m510204200
https://doi.org/10.1074/jbc.m510204200