Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dennis J Young"'
Autor:
Heekyung Chung, Dennis J Young, Claudia G Lopez, Thuy-Anh T Le, Jeffrey K Lee, Deena Ream-Robinson, Sherry C Huang, John M Carethers
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3463 (2008)
Microsatellite instability promotes colonic tumorigenesis through generating frameshift mutations at coding microsatellites of tumor suppressor genes, such as TGFBR2 and ACVR2. As a consequence, signaling through these TGFbeta family receptors is abr
Externí odkaz:
https://doaj.org/article/27f6e1c85a4d4529b5e913814679c85f
Autor:
Claudia G. Lopez, Deena Ream-Robinson, Joy Holmstrom, Dennis J. Young, Heekyung Chung, John M. Carethers, Betty L. Cabrera, Jenny F. Lai
Publikováno v:
Oncogene
The activin type II receptor (ACVR2) contains two identical microsatellites in exons 3 and 10, but only the exon 10 microsatellite is frameshifted in mismatch repair (MMR)-defective colonic tumors. The reason for this selectivity is not known. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe6f5176d8661c7fe662871927d9f8
https://doi.org/10.1038/onc.2009.508
https://doi.org/10.1038/onc.2009.508
Autor:
Scott A. Stuart, Irina C. Hunton, Yosuke Minami, Catriona Jamieson, Asoka Banno, Tomokatsu Ikawa, Cornelis Murre, Dennis J. Young, Tomoki Naoe, Yong Jiang, Jean Y. J. Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 105:17967-17972
During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear β-catenin acquire self-renewal potential and may function as leukemic stem cells (Jamieson et al. N Engl J Med , 2004). To deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea012f1482deb26484a487cd64b26ff8
https://doi.org/10.1073/pnas.0808303105
https://doi.org/10.1073/pnas.0808303105
Publikováno v:
STEM CELLS. 17:265-272
CD123 (alpha-subunit of IL-3 receptor) expression on primitive and committed human hematopoietic cells was studied by multicolor sorting and single-cell culture. The sources of cells included fetal liver (FLV), fetal bone marrow, umbilical cord blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff670cb11bc15ce0b21ea77919e1c176
https://doi.org/10.1002/stem.170265
https://doi.org/10.1002/stem.170265
Autor:
Lamia Schwarz, David Looney, Thomas A. Lane, Ping Law, Silvestre Ramos, Anthony D. Ho, Flossie Wong-Staal, Dennis J. Young, Diether J. Recktenwald, Alain Gervaix
Publikováno v:
Experimental Hematology, Vol. 27, No 1 (1999) pp. 147-54
Gene therapy is becoming one of the most promising modalities for the treatment of acquired immunodeficiency syndrome. The purpose of this study was to investigate the mobilization and collection of peripheral blood progenitor cells from human immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f9915cd605e93a0d44099d39f5ccf8
https://doi.org/10.1016/s0301-472x(98)00023-x
https://doi.org/10.1016/s0301-472x(98)00023-x
Publikováno v:
Transfusion. 39:39-47
BACKGROUND: It was previously reported that the combination of granulocyte-macrophage-colony-stimulating factor (GM–CSF) and granulocyte-CSF (G–CSF) for 4 days mobilized more primitive CD34+ subsets than did either G–CSF or GM–CSF alone. STUD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea6541c3d715b48fcb231ca55b3f102
https://doi.org/10.1046/j.1537-2995.1999.39199116893.x
https://doi.org/10.1046/j.1537-2995.1999.39199116893.x
Autor:
Osamu Yamada, Mang Yu, Anthony D. Ho, Dennis J. Young, Mark C. Leavitt, Flossie Wong-Staal, Midori Maruyama
Publikováno v:
Proceedings of the National Academy of Sciences. 92:699-703
Successful treatment of human immunodeficiency virus infection may ultimately require targeting of hematopoietic stem cells. Here we used retroviral vectors carrying the ribozyme gene to transduce CD34+ cells from human fetal cord blood. Transduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4811430cde42224674e2ffd4026bde
https://doi.org/10.1073/pnas.92.3.699
https://doi.org/10.1073/pnas.92.3.699
Autor:
M Mullen, Ping Law, A Hardwick, M Moubayed, Midori Maruyama, J Burgess, Dennis J. Young, Leon W.M.M. Terstappen, Thomas A. Lane, M Mealiffe
Publikováno v:
Blood. 85:275-282
To explore the use of stem/progenitor cells from peripheral blood (PB) for allogeneic transplantation, we have studied the mobilization of progenitor cells in normal donors by growth factors. Normal subjects were administered either granulocyte-macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4987303cd0926939dc6fbc8bbc9fbf
https://doi.org/10.1182/blood.v85.1.275.bloodjournal851275
https://doi.org/10.1182/blood.v85.1.275.bloodjournal851275
Publikováno v:
Mutation research. 729(1-2)
We previously demonstrated that exonic selectivity for frameshift mutation (exon 10 over exon 3) of ACVR2 in mismatch repair (MMR)-deficient cells is partially determined by 6 nucleotides flanking 5′ and 3′ of each microsatellite. Substitution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275756041898827ec94d900b80e0f10
https://pubmed.ncbi.nlm.nih.gov/22001236
https://pubmed.ncbi.nlm.nih.gov/22001236
Autor:
Dennis J. Young, Deena Ream-Robinson, Joy Holmstrom, Heekyung Chung, Claudia G. Lopez, John M. Carethers, Jenny F. Lai
It is generally accepted that longer microsatellites mutate more frequently in defective DNA mismatch repair (MMR) than shorter microsatellites. Indeed, we have previously observed that the A 10 microsatellite of transforming growth factor beta type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4893617726d8194bf8a0475d65a76e4c
https://europepmc.org/articles/PMC2912546/
https://europepmc.org/articles/PMC2912546/
