Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dennis J Colussi"'
Autor:
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Dennise S. Rios, Carlos A. Barrero
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1334 (2023)
Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity. Within the context of chronic obstructive pulmonary disease (COPD),
Externí odkaz:
https://doaj.org/article/b61a4355c8b8459591fafe1f7b7bb768
Autor:
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Carlos A. Barrero
Excessive extracellular histones can damage cells despite their importance in DNA structure and gene regulation. We previously showed the harmful effect of histone 3.3 (H3.3) and its acetylated form (AcH3.3) in chronic obstructive pulmonary disease (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531d186b1a702216695576830e836795
https://doi.org/10.20944/preprints202305.1200.v1
https://doi.org/10.20944/preprints202305.1200.v1
Autor:
Tyler Eck, John Gordon, Wayne E. Childers, Brandon S. Pybus, Dennis J. Colussi, Tamara Kreiss, Alison Roth, Rammohan R. Yadav Bheemanaboina, David P. Rotella, Shams Ul Mahmood, Patricia J. Lee, Purnima Bhanot, Samantha O. Aylor, Mariana Laureano de Souza, Mariana Lozano Gonzalez, John J. Siekierka
Publikováno v:
ACS Med Chem Lett
[Image: see text] The discovery of new targets for the treatment of malaria, in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8fe3378b6bb8e06313fdebf1e4dbd7
https://europepmc.org/articles/PMC8667308/
https://europepmc.org/articles/PMC8667308/
Autor:
Purnima Bhanot, Mariana Lozano Gonzalez, Brandon S. Pybus, John Gordon, Wayne E. Childers, David P. Rotella, Rammohan R. Yadav Bheemanaboina, Alison Roth, Shams Ul Mahmood, Tamara Kreiss, Tyler Eck, Mariana Laureano de Souza, John J. Siekierka, Dennis J. Colussi, Patricia J. Lee, Samantha O. Aylor
The discovery of new targets for treatment of malaria and in particular those aimed at the pre-erythrocytic stage in the life cycle, advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f95d28b1facf94164495dca7105a0f
https://doi.org/10.1101/2021.11.05.467463
https://doi.org/10.1101/2021.11.05.467463
Autor:
Mariana Lozano Gonzalez, Dennis J. Colussi, Tyler Eck, Samantha O. Aylor, Patty J. Lee, Shams Ul Mahmood, Tamara Kreiss, David P. Rotella, Brandon S. Pybus, Purnima Bhanot, Wayne E. Childers, John Gordon, Alison Roth, Rammohan R. Yadav Bheemanaboina, M. L. de Souza, John J. Siekierka
The discovery of new targets for treatment of malaria advanced with the demonstration that orally administered inhibitors of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) could clear infection in a murine model. This enthusiasm was temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c612db0e19258f774179b67ca88c35b6
https://doi.org/10.1101/2021.08.24.457553
https://doi.org/10.1101/2021.08.24.457553
Publikováno v:
ACS Chemical Neuroscience. 10:3662-3670
Cone photoreceptor cyclic-nucleotide gated channels (CNG) are tetrameric proteins composed of subunits from CNGA3 and CNGB3. These channels transduce light information into electrical signals carried by both Na+ and Ca2+ ions. More than 100 mutations
Autor:
Anjela, Manandhar, Benjamin E, Blass, Dennis J, Colussi, Imane, Almi, Magid, Abou-Gharbia, Michael L, Klein, Khaled M, Elokely
Publikováno v:
Journal of Chemical Information and Modeling
Currently the entire human population is in the midst of a global pandemic caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2). This highly pathogenic virus has to date caused >71 million infections and >1.6 million deaths in >180
Autor:
John Gordon, Rogelio Martinez, Dennis J. Colussi, Edward Melenski, Marlene A. Jacobson, Rong Fan, Yuxiao Liu, Wayne E. Childers, Magid Abou-Gharbia
Publikováno v:
Bioorg Med Chem Lett
Gaucher disease (GD) results from inherited mutations in the lysosomal enzyme β-glucocerobrosidase (GCase). Currently available treatment options for Type 1 GD are not efficacious for treating neuronopathic Type 2 and 3 GD due to their inability to
Publikováno v:
ACS chemical neuroscience. 10(8)
Cone photoreceptor cyclic-nucleotide gated channels (CNG) are tetrameric proteins composed of subunits from
Autor:
Marlene A. Jacobson, Dennis J. Colussi
Publikováno v:
SLAS Discov
Tay-Sachs disease is an inherited lysosomal storage disease resulting from mutations in the lysosomal enzyme, β-hexosaminidase A, and leads to excessive accumulation of GM2 ganglioside. Tay-Sachs patients with the infantile form do not live beyond 2