Zobrazeno 1 - 10
of 658
pro vyhledávání: '"Dennis J, Selkoe"'
Autor:
Andrew J. White, Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young-Pearse, Ulf Dettmer, Dennis J. Selkoe, Gary P. H. Ho
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences synaptic vesicle dynamics in human c
Externí odkaz:
https://doaj.org/article/d786b0ee3bd14339a2ed5d540b37e70d
Autor:
Silke Nuber, Xiaoqun Zhang, Thomas D. McCaffery, Tim E. Moors, Marie-Alexandre Adom, Wolf N. Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J. Selkoe
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Mutations in the α-Synuclein (αS) gene promote αS monomer aggregation that causes neurodegeneration in familial Parkinson’s disease (fPD). However, most mouse models expressing single-mutant αS transgenes develop neuronal aggregates ve
Externí odkaz:
https://doaj.org/article/352db539d02c431293173a6ee8a2d72f
Autor:
Silke Nuber, Xiaoqun Zhang, Thomas D. McCaffery, Tim E. Moors, Marie-Alexandre Adom, Wolf N. Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J. Selkoe
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/39b56a097da94758adbfa5ee94a878bb
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Autor:
Luis Fonseca-Ornelas, Jonathan M. S. Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina R. Muratore, Clemens R. Scherzer, Dennis J. Selkoe
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial and ‘sporadic’ Parkinson’s disease. We previously identified α-helically folded αSyn tetramers, in addition to the long-known unfolded monomers, in no
Externí odkaz:
https://doaj.org/article/e13ccbb7dccf40c0b670bee0a405f972
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/53108c19caff4a42b16e5f180df29179
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105816- (2022)
Early cognitive impairment in Alzheimer's disease may result in part from synaptic dysfunction caused by the accumulation oligomeric assemblies of amyloid β-protein (Aβ). Changes in hippocampal function seem critical for cognitive impairment in ear
Externí odkaz:
https://doaj.org/article/f1d6a1b9627d48f6b61e0a23fbabe965
Autor:
Jasmeer P. Chhatwal, Aaron P. Schultz, Yifan Dang, Beth Ostaszewski, Lei Liu, Hyun-Sik Yang, Keith A. Johnson, Reisa A. Sperling, Dennis J. Selkoe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Previously it was shown that an N-terminal tau fragment (NT1) measured in plasma can differentiate individuals with Alzheimer’s disease from healthy controls. Here the authors show that plasma levels of NT1 can associate with future cognitive decli
Externí odkaz:
https://doaj.org/article/5e6552d7e8ff43c699163b028de8f4b4
Autor:
David Mengel, Wen Liu, Robert J. Glynn, Dennis J. Selkoe, Andre Strydom, Florence Lai, H. Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian Skotko, Dominic M. Walsh
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved
Externí odkaz:
https://doaj.org/article/765d7c94e9064dc89f729ff61c72457b
Autor:
Theresa S. Rimmele, Shaomin Li, Jens Velde Andersen, Emil W. Westi, Alexander Rotenberg, Jianlin Wang, Blanca Irene Aldana, Dennis J. Selkoe, Chiye J. Aoki, Chris G. Dulla, Paul Allen Rosenberg
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
GLT-1, the major glutamate transporter in the mammalian central nervous system, is expressed in presynaptic terminals that use glutamate as a neurotransmitter, in addition to astrocytes. It is widely assumed that glutamate homeostasis is regulated pr
Externí odkaz:
https://doaj.org/article/bd922351081f490ab166d4b63a3be5b0