Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dennis Hoving"'
Autor:
Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, Elisa Theresa Helbig, Florian Kurth, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
Publikováno v:
eLife, Vol 12 (2024)
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dorna
Externí odkaz:
https://doaj.org/article/aa0642bdfc68412890699c84f062b563
Autor:
Dennis Hoving, Alexandre H. C. Marques, Wesley Huisman, Beckley A. Nosoh, Alicia C. de Kroon, Oscar R. J. van Hengel, Bing-Ru Wu, Rosanne A. M. Steenbergen, Pauline M. van Helden, Britta C. Urban, Nisha Dhar, Daniela M. Ferreira, Gaurav Kwatra, Cornelis H. Hokke, Simon P. Jochems
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Bacterial capsular polysaccharides are important vaccine immunogens. However, the study of polysaccharide-specific immune responses has been hindered by technical restrictions. Here, we developed and validated a high-throughput method to ana
Externí odkaz:
https://doaj.org/article/9cc08f4b95f4401d8d74a185a887fc67
Autor:
Marianna Ioannou, Dennis Hoving, Iker Valle Aramburu, Mia I. Temkin, Nathalia M. De Vasconcelos, Theodora-Dorita Tsourouktsoglou, Qian Wang, Stefan Boeing, Robert Goldstone, Spyros Vernardis, Vadim Demichev, Markus Ralser, Sascha David, Klaus Stahl, Christian Bode, Venizelos Papayannopoulos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Hyperinflammation and immune dysfunction are key drivers of immunopathology in sepsis. Here the authors show microbial exploitation of phagocytic receptors is linked to triggering of sepsis and the immune cell mediated reduction in neutrophil life sp
Externí odkaz:
https://doaj.org/article/16a60dd84fd94a0a9691874f1193e9ac
Autor:
Theodora-Dorita Tsourouktsoglou, Annika Warnatsch, Marianna Ioannou, Dennis Hoving, Qian Wang, Venizelos Papayannopoulos
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Neutrophil extracellular traps (NETs) promote atherosclerosis by inducing proinflammatory cytokines, but the underlying mechanism remains unknown. NET DNA is immunogenic, but given the cytotoxicity of NET histones, it is unclear how it activ
Externí odkaz:
https://doaj.org/article/192a85da4fe547408d7da55ec0aebd18
Autor:
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I. Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
BackgroundSARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dfe7d4ab8b1c52fd3a97d5be18ddbe
https://doi.org/10.1101/2022.04.14.22272888
https://doi.org/10.1101/2022.04.14.22272888
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha C.F. Tin, Marianna Ioannou, Mia I. Temkin, Nathalia M. De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
Publikováno v:
Immunity.
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes wi
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha Tin, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Marianna Ioannou, Mia I. Temkin, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
SummaryHyperinflammation, coagulopathy and immune dysfunction are prominent in patients with severe infections. Extracellular chromatin clearance by plasma DNases suppresses such pathologies in mice but whether severe infection interferes with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad05c0917f5cc4186881d15f79f56d4
https://doi.org/10.1101/2022.01.25.22269616
https://doi.org/10.1101/2022.01.25.22269616
Autor:
Venizelos Papayannopoulos, Marianna Ioannou, Mia I. Temkin, Klaus Stahl, Spyros I. Vernardis, Sascha David, Dennis Hoving, Nathalia M. De Vasconcelos, Iker Valle Aramburu, Markus Ralser, Theodora-Dorita Tsourouktsoglou, Stefan Boeing, Christian Bode, Qian Wang, Robert L. Goldstone, Vadim Demichev
SummaryThe mechanisms regulating immune dysfunction during sepsis are poorly understood. Here, we show that neutrophil-derived myeloperoxidase delays the onset of immune dysfunction during systemic candidiasis by controlling microbes captured by sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e352b8c222ee6d3768c2578fc128d6e2
https://doi.org/10.1101/2021.08.09.455510
https://doi.org/10.1101/2021.08.09.455510