Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dennis Heller"'
Publikováno v:
Drug metabolism letters. 10(4)
Objective This study describes the in vivo pharmacokinetics and metabolism of [14C]labeled XQ-1H in male rats. Methods XQ-1H is a methanesulfonate of XQ, 10-O-(N,N-dimethylaminoethyl)-ginkgolide B, a derivative of ginkgolide B (GB) with enhanced wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65b4cb2f8fb4ba79b9611af7fe169ce
https://pubmed.ncbi.nlm.nih.gov/28103788
https://pubmed.ncbi.nlm.nih.gov/28103788
Autor:
Dorota Cedzik, Zhe-ming Gu, Oscar L. Laskin, Anfan Wu, Lori Capone, Sekhar Surapaneni, Peter H. Schafer, Gondi Kumar, Kei-Lai Fong, Dennis Heller, Matthew Hoffmann, Hao Feng
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a12f1882b88e0997a57b9ad4adcbb73
https://doi.org/10.3109/00498254.2011.604745
https://doi.org/10.3109/00498254.2011.604745
Autor:
Dennis Heller
Publikováno v:
The Reference Librarian. 27:121-133
Using the Internet as an information source is a fairly new proposition for most researchers, but the depth and breadth of coverage on the net mark it as an important research tool. While the prospect of having volumes of data at one' s fingertips ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c525b3bc4b591a085f04204ab6505f
https://doi.org/10.1300/j120v27n58_12
https://doi.org/10.1300/j120v27n58_12
Autor:
Shane Karnik, Corey Nehls, Lorella Di Donato, Shane Needham, Saadya Fatmi, Jim Hillier, James Truog, Mike Allen, Mario Rocci, Dennis Heller, Kirk R. Smith, Ejvind Mørtz, Curtis Sheldon, Farhad Sayyarpour, Theo de Boer, Ronald Shoup, Natasha Savoie, Zhongping John Lin, Jenifer Vija, Ray Steffen, Robert Nicholson, John Kamerud, Alan Breau, Neil Berger, Leonardo de Souza Teixeira, Sofi Gagnon-Carignan, Richard Lundberg, Laura Cojocaru, Maria Cruz Caturla, Jim Jersey, Saleh Hussain, Jianine Jonker, Steve Lowes, Richard Houghton, Michele Malone, Marc Moussallie, Fabio Garofolo, Steve Michael, Tammy Harter, Martijn Hilhorst, Roger Hayes, Tim Samuels, Mike Buonarati, Tianyi Zhang
Publikováno v:
Bioanalysis. 3(12)
“The Global CRO Council (GCC) for Bioanalysis was formed in an effort to bring together many CRO leaders to openly discuss bioanalysis and the regulatory challenges unique to the outsourcing industry”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0278e655070669af0761a249e1f2b6
https://pubmed.ncbi.nlm.nih.gov/21679026
https://pubmed.ncbi.nlm.nih.gov/21679026
Autor:
Nicole Sadowski, Paul Tardi, Dennis Heller, Xiaowei Xie, Lawrence D. Mayer, Donna Cabral-Lilly
Publikováno v:
Blood. 124:3740-3740
Background: CPX-351 is a liposomal formulation co-encapsulating Cyt and Daun, that delivers the drugs in vivo at a 5:1 molar ratio shown to be synergistic preclinically. Clinically, CPX-351 has provided evidence of promising improvements in patient o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4640fa364f83d3a9633e45e520f7fd
https://doi.org/10.1182/blood.v124.21.3740.3740
https://doi.org/10.1182/blood.v124.21.3740.3740
Autor:
Heasook Kim-Kang, Dennis Heller, Xiaowei Xi, Lawrence D. Mayer, Peter Wang, Paul Tardi, Jeffrey Fulton, Yijun Yi
Publikováno v:
Blood. 124:2305-2305
Background: CPX-351 is a liposome formulation of Cyt and Daun in which the 5:1 molar ratio of the two drugs optimizes synergy. The marked increase in efficacy observed preclinically for CPX-351 versus the combination given in a non-liposomal (NL) sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d30e1a01e44af132652c5028323a82c
https://doi.org/10.1182/blood.v124.21.2305.2305
https://doi.org/10.1182/blood.v124.21.2305.2305