Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dennis Han Zhang"'
Autor:
Chenxi Gao, Guangming Chen, Dennis Han Zhang, Judy Zhang, Shih-Fan Kuan, Wenhuo Hu, Farzad Esni, Xuan Gao, Jun-Lin Guan, Edward Chu, Jing Hu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 561-578 (2019)
Background & Aims: Identification and validation of new functionally relevant and pharmacologically actionable targets for pancreatic ductal adenocarcinoma (PDAC) remains a great challenge. Premalignant acinar cell reprogramming (acinar-to-ductal met
Externí odkaz:
https://doaj.org/article/9b0a9f3766f74e40b89576bec27edfa5
Publikováno v:
eLife, Vol 4 (2015)
Aberrant activation of Wnt/β-catenin signaling plays an unequivocal role in colorectal cancer, but identification of effective Wnt inhibitors for use in cancer remains a tremendous challenge. New insights into the regulation of this pathway could re
Externí odkaz:
https://doaj.org/article/7c225258e1c14ad683c3139467e3d970
Autor:
Jing Hu, Timothy F. Burns, Shih-Fan Kuan, Dennis Han Zhang, Xuan Gao, Chenxi Gao, Guangming Chen
One of the most encouraging developments in oncology has been the success of BRAF inhibitors in BRAF-mutant melanoma. However, in contrast to its striking efficacy in BRAF-mutant melanomas, BRAF inhibitor monotherapy is ineffective in BRAF-mutant col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ace12d66e9451ae67ee527369b73d9f
https://doi.org/10.1158/1535-7163.c.6538000.v1
https://doi.org/10.1158/1535-7163.c.6538000.v1
Autor:
Jing Hu, Timothy F. Burns, Shih-Fan Kuan, Dennis Han Zhang, Xuan Gao, Chenxi Gao, Guangming Chen
Supplementary Figure 1: BRAF inhibitor increase nuclear β-catenin in BRAF-mutant CRC cells; Supplementary Figure 2: Wnt/β-catenin pathway activation induced by BRAF inhibitor is dependent on FAK; Supplementary Figure 3: FAK inhibitor synergizes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d43ad7445438226069359dcc2ac084d
https://doi.org/10.1158/1535-7163.22505239.v1
https://doi.org/10.1158/1535-7163.22505239.v1
Autor:
Dennis Han Zhang, Xuan Gao, Wenhuo Hu, Farzad Esni, Chenxi Gao, Edward Chu, Jun Lin Guan, Guangming Chen, Judy Zhang, Jing Hu, Shih-Fan Kuan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 561-578 (2019)
Background & Aims: Identification and validation of new functionally relevant and pharmacologically actionable targets for pancreatic ductal adenocarcinoma (PDAC) remains a great challenge. Premalignant acinar cell reprogramming (acinar-to-ductal met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a93dabaafc48a574682048ecef56176
https://doi.org/10.1016/j.jcmgh.2019.07.004
https://doi.org/10.1016/j.jcmgh.2019.07.004
Publikováno v:
Cancer Research. 77:LB-310
Since nearly 100% of pancreatic ductal adenocarcinoma (PDAC) carried mutational activation of KRAS, KRAS and its effectors are theoretically ideal candidates for PDAC therapeutic intervention. Unfortunately, attempts to directly inhibit oncogenic KRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8546a727e18bd7c4ef185fb5cf01cf0b
https://doi.org/10.1158/1538-7445.am2017-lb-310
https://doi.org/10.1158/1538-7445.am2017-lb-310
Publikováno v:
Cancer Research. 75:LB-033
Aberrant activation of Wnt/β-catenin signaling plays an unequivocal role in colorectal cancer (CRC), but identification of effective Wnt inhibitors for use in cancer remains a tremendous challenge. New insights into the regulation of this pathway co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf0babd846b2d76df99f9160bf1e1fe
https://doi.org/10.1158/1538-7445.am2015-lb-033
https://doi.org/10.1158/1538-7445.am2015-lb-033