Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dennis Greenslade"'
Autor:
Merrill J. Egorin, Sunil Sharma, Jean L. Grem, Dennis Greenslade, Ramesh K. Ramanathan, Andrew Goetz, Anne Hamilton, Chee M. Ng, Percy Ivy, James H. Doroshow, Chris H. Takimoto, Daniel Mulkerin, Sridhar Mani, Scot C. Remick, Graham F. Lockwood, Martin A. Graham, Timothy W. Synold
Publikováno v:
Clinical Cancer Research. 13:4832-4839
Purpose: To characterize the pharmacokinetics and pharmacodynamics of oxaliplatin in cancer patients with impaired renal function. Experimental Design: Thirty-four patients were stratified by 24-h urinary creatinine clearance (CrCL) into four renal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc55f483ec07314bf2bcef670a8651bb
https://doi.org/10.1158/1078-0432.ccr-07-0475
https://doi.org/10.1158/1078-0432.ccr-07-0475
Publikováno v:
Journal of Applied Toxicology. 22:437-443
The purpose of this study was to compare the ability of non-compartmental analysis and compartmental mixed effects modelling (MEM) to determine the existence and magnitude of exposure differences (i.e. exposure ratio estimates) between subsets of ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eba00c7139c1337d4c8a0ad2178a7d8
https://doi.org/10.1002/jat.883
https://doi.org/10.1002/jat.883
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 28:465-479
The purpose of this study was to examine how best to incorporate plasma samples which fall below an assay's lower limit of quantification into the process of toxicokinetic data modeling. Secondly to establish what proportion of data can be below the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07cfbdbb5ab36ad208d47fca2cea9df7
https://doi.org/10.1023/a:1012247131190
https://doi.org/10.1023/a:1012247131190
Autor:
J.Gilmour Morrison, Martin A. Graham, Peter White, Dennis Greenslade, Steve G Woolfrey, John W Firth, Sophie McDougall
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 24:1-10
ELOXATIN (Oxaliplatin) is a novel platinum containing anti-cancer agent with a diaminocyclohexane carrier ligand which has been approved in several major European countries. Clinical studies have demonstrated that the compound exhibits marked activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476e08ad13b6e04193402a57a99421cd
https://doi.org/10.1016/s0731-7085(00)00377-0
https://doi.org/10.1016/s0731-7085(00)00377-0
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 19:1047-1059
This study describes a highly sensitive, solid-phase extraction-HPLC/MS/MS assay for cyclophosphamide in human plasma, with a minimum quantifiable level of 0.025 μg mL−1. Plasma samples (0.5 mL) we...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cebec3b438bc97c5e9b9bcf63c6fa35
https://doi.org/10.1080/10826079608006301
https://doi.org/10.1080/10826079608006301
Autor:
P. A. Fox, J Rogers, G F Lockwood, Dennis Greenslade, K Lasher, H. Thysell, Dennis Lendrem, S. G. Woolfrey, J Hegbrant
Publikováno v:
Journal of Pharmacy and Pharmacology. 47:651-655
This study was designed to test a proposed dose modification for intravenous milrinone in congestive heart failure patients (CHF, NYHA I-II) with either moderate or severe renal impairment. All the patients were administered an intravenous loading do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed979862d7a8bb212ca46bd1e25817ab
https://doi.org/10.1111/j.2042-7158.1995.tb05853.x
https://doi.org/10.1111/j.2042-7158.1995.tb05853.x
Autor:
Hernani Robin, Nils Eckhardt, Jeffery Hincks, Dennis Greenslade, Martin A. Graham, Stanley B. Kaye, Reinhard von Roemeling, Suresh Senan, Paul Workman, Dennis Lendrem, R. Rampling
Publikováno v:
Cancer Chemotherapy and Pharmacology, 40(1), 1-10. Springer Verlag
Graham, M A, Senan, S, Robin, H, Eckhardt, N, Lendrem, D, Hincks, J, Greenslade, D, Rampling, R, Kaye, S B, Von Roemeling, R & Workman, P 1997, ' Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans : Retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a a phase I trial ', Cancer Chemotherapy and Pharmacology, vol. 40, no. 1, pp. 1-10 . https://doi.org/10.1007/s002800050617
Graham, M A, Senan, S, Robin, H, Eckhardt, N, Lendrem, D, Hincks, J, Greenslade, D, Rampling, R, Kaye, S B, Von Roemeling, R & Workman, P 1997, ' Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans : Retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a a phase I trial ', Cancer Chemotherapy and Pharmacology, vol. 40, no. 1, pp. 1-10 . https://doi.org/10.1007/s002800050617
Tirapazamine (3-amino-1,2,4-benzotriazine-1,4-di-N-oxide; SR 259075) is a selective hypoxic cell cytotoxic agent: that is bioreductively activated in tumours to a reactive-drug free radical. Preclinically the agent has been shown to possess additive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d913fa7eb2fd6649ac07cb61c53ba2
https://research.vumc.nl/en/publications/08027d32-f16a-4ece-a5ae-59811c1dc12e
https://research.vumc.nl/en/publications/08027d32-f16a-4ece-a5ae-59811c1dc12e
Autor:
Peter O'Dwyer, C A Johnson, E Keenan, R. von Roemeling, Martin A. Graham, G Kennedy, Deborah Kilpatrick, Corey J. Langer, Dennis Greenslade
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 15(2)
PURPOSE AND METHODS Tirapazamine (SR4233, WIN 59075) is a benzotriazine-di-N-oxide bioreductive agent that is selectively activated to a reactive DNA-damaging species in hypoxic tumors. Preclinical studies show that synergistic antitumor activity res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45f50ebcc9fffc9b49dd19db6bfc015
https://pubmed.ncbi.nlm.nih.gov/9053504
https://pubmed.ncbi.nlm.nih.gov/9053504
Autor:
Joseph Lafferty, T. George Truscott, David T. Birtwistle, David C. Blackley, Eamon F. Jeffers, A. Ian Scott, C.-L. Yeh, Dennis Greenslade, Masahiro Kajiwara, S.-F. Lee, M. Akhtar, C. R. Jones, Peter M. Jordan
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :192
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa0136e657e75fba2eb0e5cbc839b5d
https://doi.org/10.1039/c39790000192
https://doi.org/10.1039/c39790000192
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :947
The alkaloid vallesamine has been prepared by partial synthesis from stemmadenine using a modified Polonovsky reaction in a sequence which provides a biogenetic model for this class of alkaloid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::411584083fa294f627373bcfccf01b47
https://doi.org/10.1039/c39780000947
https://doi.org/10.1039/c39780000947