Sex-specific molecular signature of mouse podocytes in homeostasis and in response to pharmacological challenge with rapamycin

Autor: Ola Al-Diab, Christin Sünkel, Eric Blanc, Rusan Ali Catar, Muhammad Imtiaz Ashraf, Hongfan Zhao, Pinchao Wang, Markus M. Rinschen, Raphaela Fritsche-Guenther, Florian Grahammer, Sebastian Bachmann, Dieter Beule, Jennifer A. Kirwan, Nikolaus Rajewsky, Tobias B. Huber, Dennis Gürgen, Angelika Kusch

Publikováno v: Biology of Sex Differences, Vol 15, Iss 1, Pp 1-24 (2024)

Abstract Background Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-type in the kidney which maintain the physiological blood-urine barrier, and pathological changes in podocyte h

Externí odkaz: https://doaj.org/article/6486c593796f4fa4bf8ff685f8544f3b

Breaking the crosstalk of the Cellular Tumorigenic Network by low-dose combination therapy in lung cancer patient-derived xenografts

Autor: Dennis Gürgen, Theresia Conrad, Michael Becker, Susanne Sebens, Christoph Röcken, Jens Hoffmann, Stefan Langhammer

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)

The identification of novel therapeutic strategies for advanced non-small cell lung cancer (NSCLC) is essential as the outcome of most of these patients is poor. Here the authors provide a proof-of concept that specific low-dose drug combinations can

Externí odkaz: https://doaj.org/article/92f28987a8ba465c999b6d45aa1fdeb2

Correction to: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Autor: Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Günther H. S. Richter

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-3 (2022)

An amendment to this paper has been published and can be accessed via the original article.

Externí odkaz: https://doaj.org/article/e2b35416a024402dba01b1542821c08e

Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.

Autor: Ye Zhu, Maximilian Blum, Uwe Hoff, Tim Wesser, Mandy Fechner, Christina Westphal, Dennis Gürgen, Rusan Ali Catar, Aurelie Philippe, Kaiyin Wu, Gordana Bubalo, Michael Rothe, Steven M Weldon, Duska Dragun, Wolf-Hagen Schunck

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0145645 (2016)

AIM:20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-dependent eicosanoids that play opposite roles in the regulation of vascular tone, inflammation, and apoptosis. 20-HETE aggravates, whereas E

Externí odkaz: https://doaj.org/article/bf252068991546c0a8d08f0a533dd4f6

Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance

Autor: Sara G. Danielli, Ermelinda Porpiglia, Andrea J. De Micheli, Natalia Navarro, Michael J. Zellinger, Ingrid Bechtold, Samanta Kisele, Larissa Volken, Joana G. Marques, Stephanie Kasper, Peter K. Bode, Anton G. Henssen, Dennis Gürgen, Olivier Delattre, Didier Surdez, Josep Roma, Peter Bühlmann, Helen M. Blau, Marco Wachtel, Beat W. Schäfer

Publikováno v: Science Advances, 9 (6)
Danielli, S G, Porpiglia, E, De Micheli, A J, Navarro, N, Zellinger, M J, Bechtold, I, Kisele, S, Volken, L, Marques, J G, Kasper, S, Bode, P K, Henssen, A G, Gürgen, D, Delattre, O, Surdez, D, Roma, J, Bühlmann, P, Blau, H M, Wachtel, M & Schäfer, B W 2023, ' Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance ', Science Advances, vol. 9, no. 6, eade9238 . https://doi.org/10.1126/sciadv.ade9238

Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest remain elusive. Here, we combined single-cell RNA sequencing, mass cytometry, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4a878ea2cde7eec5bf8ac9c8637212
https://hdl.handle.net/20.500.11850/598915