Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dennis France"'
Publikováno v:
Journal of Natural Products. 67:1010-1013
Two novel omega3 fatty acids, obtained as monoacyl glycerol derivatives, were isolated as DNA methyl transferase inhibitors following bioassay-guided fractionation of the Fijian red marine alga Peyssonnelia caulifera. Both active metabolites, peysson
Autor:
Stacy W. Remiszewski, Lidia C. Sambucetti, Kenneth W. Bair, John Bontempo, David Cesarz, Nagarajan Chandramouli, Ru Chen, Min Cheung, Susan Cornell-Kennon, Karl Dean, George Diamantidis, Dennis France, Michael A. Green, Kobporn Lulu Howell, Rina Kashi, Paul Kwon, Peter Lassota, Mary S. Martin, Yin Mou, Lawrence B. Perez, Sushil Sharma, Troy Smith, Eric Sorensen, Francis Taplin, Nancy Trogani, Richard Versace, Heather Walker, Susan Weltchek-Engler, Alexander Wood, Arthur Wu, Peter Atadja
Publikováno v:
Journal of Medicinal Chemistry. 46:4609-4624
A series of N-hydroxy-3-phenyl-2-propenamides were prepared as novel inhibitors of human histone deacetylase (HDAC). These compounds were potent enzyme inhibitors, having IC50s < 400 nM in a partially purified enzyme assay. However, potency in cell g
Autor:
Phillip Crews, William Gerwick, Francis Schmitz, Dennis France, Kenneth Bair, Amy Wright, Yali Hallock
Publikováno v:
Pharmaceutical Biology. 41:39-52
This paper outlines the results of a collaborative program begun in 1990 under the NIH National Cooperative Drug Discovery Group (NCDDG) program. It involves the unified research of a multi-institutional group from both academic and corporate laborat
Autor:
Helen Mason, Simon Scrace, Richard Testar, Julie Rainard, Fatima Talab, Ryaka Poonawala, Philippa Smith, Harriet Brooke, Sarah Frith, Jonathan Ahmet, Jonathan Hall, David Sorrell, Jon Moore, Caroline Phillips, Dennis France, Matilda Bingham, Richard Armer
Publikováno v:
Cancer Research. 77:5160-5160
REDX05358 has been identified as a novel, highly selective and potent next generation pan RAF inhibitor with improved therapeutic potential and predicted safety profile. Aberrant signalling via the MAPK pathway is commonly seen in cancer. RAF inhibit
Autor:
Peter Ettmayer, Dennis France, John Gounarides, Mark Jarosinski, Mary-Sue Martin, Jean-Michel Rondeau, Michael Sabio, Sid Topiol, Beat Weidmann, Mauro Zurini, Kenneth W. Bair
Publikováno v:
Journal of Medicinal Chemistry. 42:971-980
Following earlier work on cystine-bridged peptides, cyclic phosphopeptides containing nonreducible mimics of cystine were synthesized that show high affinity and specificity toward the Src homology (SH2) domain of the growth factor receptor-binding p
Autor:
Sujatha Kumar, Felicia Zhao, Anatoly Myaskovsky, Lydia Kifle, Nicola McCarthy, Jon Moore, Dennis France, Janine Steiger, W. Frank An
Publikováno v:
Cancer Research. 76:353-353
Cancer immunotherapy has greatly expanded the therapeutic options against cancer. Recently approved antibody immunotherapies targeting immune-checkpoint molecules expressed on active T cells have shown promise in providing durable clinical anti-tumor
Publikováno v:
Journal of Natural Products. 65:51-53
The Indonesian red alga Vidalia sp. was identified as a candidate for fractionation because its crude lipid extract showed activity in a mechanism-based anticancer assay (Fyn SH2-inhibitory activity). A chemically novel phenolic metabolite, vidalenol
Autor:
Marcelino Gutiérrez, Eric H. Andrianasolo, Won Kyo Shin, Douglas E. Goeger, Alexandre Yokochi, Jörg Schemies, Manfred Jung, Dennis France, Susan Cornell-Kennon, Eun Lee, William H. Gerwick
Publikováno v:
The Journal of organic chemistry. 74(15)
Tanikolide seco-acid 2 and tanikolide dimer 3, the latter a novel and selective SIRT2 inhibitor, were isolated from the Madagascar marine cyanobacterium Lyngbya majuscula. The structure of 2, isolated as the pure R enantiomer, was elucidated by X-ray
Autor:
Jeffrey Szwaya, Charles Bruseo, Enkeleda Nakuci, Denise McSweeney, Xiaoqin Xiang, David Senator, Dennis France, Chang-Rung Chen
Publikováno v:
Journal of biomolecular screening. 12(2)
Oncology drug discovery is, by definition, a target-rich enterprise. High-throughput screening (HTS) laboratories have supported a wide array of molecularly targeted and chemical genomic approaches for anticancer lead generation, and the number of hi
Publikováno v:
Journal of natural products. 69(4)
Three new halogenated monoterpenes, 2, 3, and 4, along with the known compounds halomon (1) and two analogues, 5 and 6, were isolated from the Madagascar red marine alga Portieria hornemannii. The structures of all three new compounds were determined