Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dennis Farrelly"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9c9221e9206ed0e57f44f10281d7ab
https://doi.org/10.1016/j.bmcl.2015.01.066
https://doi.org/10.1016/j.bmcl.2015.01.066
Autor:
Lori Kunselman, Narayanan Hariharan, Pathanjali Kadiyala, Kenneth T. Locke, Denis E. Ryono, Thomas Harrity, Wei Wang, Arthur M. Doweyko, Randy Ponticiello, Liqun Gu, Pratik Devasthale, Lisa Zhang, Dennis Farrelly, Rachel Zebo, Michael Cap, Robert Zahler, Jodi K. Muckelbauer, Chiehying Chang, Cuixia Chu, Peter T. W. Cheng, Kevin O’Malley, Nathan Morgan, Litao Zhang, Jonathan Lippy, Vinayak Hosagrahara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1939-1944
A novel class of azetidinone acid-derived dual PPARalpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPARalp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bfbf6fa4536695047baca135da5c60
https://doi.org/10.1016/j.bmcl.2008.01.126
https://doi.org/10.1016/j.bmcl.2008.01.126
Autor:
Gary J. Grover, Narayanan Hariharan, Wei Wang, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Rajasree Golla, Zhengping Ma, Lisa Moore, Arthur M. Doweyko, Gamini Chandrasena, Pratik Devasthale, Denis E. Ryono, Lin Cheng, Chen Sean, Peter T. W. Cheng, Wei Sun, Ramakrishna Seethala, Paul G. Sleph, Hao Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2312-2316
A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd833e6d647f89a09342d5bb9c6b46a1
https://doi.org/10.1016/j.bmcl.2007.01.060
https://doi.org/10.1016/j.bmcl.2007.01.060
Autor:
Narayanan Hariharan, Kasim A. Mookhtiar, Liqun Gu, Jimmy Ren, Chen Sean, Ramakrishna Seethala, Michael Cap, Lori Kunselman, Min Zhou, Peter T. W. Cheng, William Fenderson, Chunning Shao, Cuixia Chu, Scott A. Biller, Hao Zhang, Fucheng Qu, Pratik Devasthale, Dennis Farrelly, Jeon Yoon T, Randolph P. Ponticiello, John R. Wetterau, Wei Wang, Wen-Pin Yang, Thomas Harrity, Aaron Tieman, Denis E. Ryono, Richard E. Gregg
Publikováno v:
Diabetes. 55:240-248
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor (PPAR) activator, was investigated for its antidiabetic properties and its effects on metabolic abnormalities in genetically obese diabetic db/db mice. In db/db mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d94ba455d51e1e5f39b4a1484a6b08
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
https://doi.org/10.2337/diabetes.55.01.06.db05-0648
Autor:
Denis E. Ryono, Chen Sean, Pratik Devasthale, Shu Y Chang, John R. Wetterau, W. Griffith Humphreys, Gary J. Grover, Dennis Farrelly, Jeon Yoon T, Fucheng Qu, Ramakrishna Seethala, Narayanan Hariharan, Wei Wang, Zhengping Ma, Scott A. Biller, Rajasree Golla, Lisa Moore, Arthur M. Doweyko, Michael Cap, Fred Selan, Jimmy Ren, Paul G. Sleph, Hao Zhang, Aaron Tieman, Vito G. Sasseville, Thomas Harrity, Gamini Chandrasena, Chunning Shao, Peter T. W. Cheng, Lin Cheng, Wei Sun
Publikováno v:
Journal of Medicinal Chemistry. 48:2248-2250
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent activity in vitro at human PPARalpha (EC(50) = 320 nM) and PPARgamma(EC(50) = 110 nM). Compound 2 shows excellent efficacy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4290978295e11d6657e63d9f0bae7a68
https://doi.org/10.1021/jm0496436
https://doi.org/10.1021/jm0496436
Autor:
Aneka Bell, Lisa Zhang, Dennis Farrelly, Denis E. Ryono, Robert Zahler, Jodi K. Muckelbauer, Jonathan Lippy, Chiehying Chang, Cuixia Chu, Thomas Harrity, Carrie Xu, Narayanan Hariharan, Neil Flynn, Vinayak Hosagrahara, Wei Wang, Michael Cap, Lisa Moore, Pathanjali Kadiyala, Peter T. W. Cheng, Hao Zhang, Liqun Gu, Litao Zhang, Kevin O’Malley, Arthur M. Doweyko, Nathan Morgan, Pratik Devasthale, Kenneth T. Locke, Lori Kunselman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
The design, synthesis and structure–activity relationships of a novel series of N-phenyl-substituted pyrrole, 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands are outlined. The triazole acid analogs 3f and 4f were identified as potent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7769b1a27b26770819589b82407e277
https://pubmed.ncbi.nlm.nih.gov/19201606
https://pubmed.ncbi.nlm.nih.gov/19201606
Autor:
Kenneth T. Locke, Jonathan Lippy, Dennis Farrelly, Neil Flynn, Narayanan Hariharan, Liqun Gu, Yi-Xin Li, Celeste Twamley, Robert Zahler, Xiang-Yang Ye, Kevin O’Malley, Litao Zhang, Denis E. Ryono, Peter T. W. Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(12)
Several series of substituted dehydropiperidine and piperidine-4-carboxylic acid analogs have been designed and synthesized as novel, potent dual PPARalpha/gamma agonists. The SAR of these series of analogs is discussed. A rare double bond migration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7aaf180f17b71778a20b2e67cb5270e
https://pubmed.ncbi.nlm.nih.gov/18511276
https://pubmed.ncbi.nlm.nih.gov/18511276
Autor:
Jean M. Whaley, Andrew Peters, Rachel Zebo, Lori Kunselman, Pratik Devasthale, Evan B. Janovitz, Thomas Harrity, Randolph P. Ponticiello, Narayanan Hariharan, Ada Staal, Dennis Farrelly, Michele H. French, JoAnn Swartz, Donald Egan, Effie Tozzo, Peter T. W. Cheng, Gustav E Welzel, Simeon Taylor, Rene Belder, Chen Sean, Liqun Gu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(1)
There are two major defects in type 2 diabetes: 1) insulin resistance and 2) insulin deficiency due to loss of beta-cell function. Here we demonstrated that treatment with muraglitazar (a dual peroxisome proliferator-activated receptor alpha/gamma ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2613bc4a81f4fb63ea35a1bdaf3959c
https://pubmed.ncbi.nlm.nih.gov/17259449
https://pubmed.ncbi.nlm.nih.gov/17259449
Autor:
Dennis Farrelly, Narayanan Hariharan, Rajasree Golla, Lin Cheng, Jonathan Lippy, Hao Zhang, Ramakrishna Seethala, Zhengping Ma, Peter T. W. Cheng, Kevin O’Malley, Kasim A. Mookhtiar, Litao Zhang
Publikováno v:
Analytical biochemistry. 363(2)
Peroxisome proliferator-activated receptors (PPARs) and other members of the nuclear hormone receptor family are important drug targets for the treatment of metabolic diseases. PPARalpha and PPARgamma play crucial roles in lipid and glucose metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e214d784ff62126d49739086aa69cd
https://pubmed.ncbi.nlm.nih.gov/17335769
https://pubmed.ncbi.nlm.nih.gov/17335769
Autor:
Pratik V, Devasthale, Sean, Chen, Yoon, Jeon, Fucheng, Qu, Denis E, Ryono, Wei, Wang, Hao, Zhang, Lin, Cheng, Dennis, Farrelly, Rajasree, Golla, Gary, Grover, Zhengping, Ma, Lisa, Moore, Ramakrishna, Seethala, Wei, Sun, Arthur M, Doweyko, Gamini, Chandrasena, Paul, Sleph, Narayanan, Hariharan, Peter T W, Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(8)
A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9ce72890feecec8742fc4d1948e12b
https://pubmed.ncbi.nlm.nih.gov/17292606
https://pubmed.ncbi.nlm.nih.gov/17292606