Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Dennis E. Epps"'
Publikováno v:
Neurobiology of Disease, Vol 14, Iss 3, Pp 567-578 (2003)
The mechanism by which amyloid peptide (Aβ1–40) produces effects on neurotransmission is currently unresolved. In initial experiments, using the patch-clamp technique, we found that 11.5 μM of preaggregated Aβ1–40 altered the hippocampal neuro
Externí odkaz:
https://doaj.org/article/2a9ea2a151a9414392e6dbc93fd063a8
Autor:
John M. McCall, Dennis E. Epps
Publikováno v:
Handbook of Synthetic Antioxidants ISBN: 9780367813543
Handbook of Synthetic Antioxidants
Handbook of Synthetic Antioxidants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db438ebed16f5254b560c13b364d9ab
https://doi.org/10.1201/9780367813543-3
https://doi.org/10.1201/9780367813543-3
Autor:
Christine Castle, Bruce M. Taylor, Donald B. Carter, George W. Melchior, Nancy C. Stratman, Dennis E. Epps
Publikováno v:
Chemistry and Physics of Lipids. 137:52-61
Brain plaque deposits of amyloid-beta peptide (Abeta) is a pathological hallmark of Alzheimer's disease (AD) and apolipoprotein E (apoE) is thought to be involved in its deposition. One hypothesis for the role of apoE in the pathogenesis of AD is tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d885545b93693a1647d94efaae9fcc0e
https://doi.org/10.1016/j.chemphyslip.2005.06.005
https://doi.org/10.1016/j.chemphyslip.2005.06.005
Autor:
Thomas T. Kawabe, Karl Kappenman, Roger A. Poorman, Barry S. Lutzke, Dennis E. Epps, Antonio Molinari, Ronald W. Sarver, Allen E. Buhl, Bruce M. Taylor, Gregory J. Fici
Publikováno v:
Journal of Protein Chemistry. 22:31-40
The time dependency of the spontaneous aggregation of the fibrillogenic beta-amyloid peptide, Abeta1-40, was measured by turbidity, circular dichroism, HPLC, and fluorescence polarization. The results by all methods were comparable and they were most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd06409a74d4cc1d4f1a2d9b233cac
https://doi.org/10.1023/a:1023063626770
https://doi.org/10.1023/a:1023063626770
Autor:
Jack DeZwaan, Brian J. Stockman, Dennis E. Epps, Ronald W. Sarver, Eric T. Baldwin, Joseph M. Rogers, Melissa S. Harris
Publikováno v:
Analytical Biochemistry. 309:186-195
Several small molecules identified by high-throughput screening (HTS) were evaluated for their ability to bind to a nonstructural protein 3 (NS3) helicase from hepatitis C virus (HCV). Equilibrium dissociation constants (K(d)'s) of the compounds for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553d8d60df003079decfb3093de0851b
https://doi.org/10.1016/s0003-2697(02)00301-9
https://doi.org/10.1016/s0003-2697(02)00301-9
Publikováno v:
Journal of Biomolecular Screening. 7:21-28
We used a temperature-jump isothermal denaturation procedure with various methods of detection to evaluate the quality of putative inhibitors of MurB discovered by high-throughput screening. Three optical methods of detection-ultraviolet hyperchromic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5311b6bcd186d3223d44f7cdf88dfe
https://doi.org/10.1089/108705702753520305
https://doi.org/10.1089/108705702753520305
Autor:
Dennis E. Epps, Anne F. Vosters
Publikováno v:
Chemistry and Physics of Lipids. 114:113-122
Cholesteryl ester transfer protein (CETP) has at least one unpaired sulfhydryl residue, which we have shown previously to be in or near the active site region. We investigated the location of this unpaired cysteine residue(s) of CETP using chemical m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8df724bd25dcc66d0d096a35b4ca44c
https://doi.org/10.1016/s0009-3084(01)00187-6
https://doi.org/10.1016/s0009-3084(01)00187-6
Publikováno v:
Analytical Biochemistry. 275:141-147
A sensitive fluorescence resonance energy transfer method was developed for the direct measurement of the dissociation constants of stromelysin inhibitors. The method is applied to the thiadiazole class of stromelysin inhibitors and it takes advantag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cc78230893307a4b21c46dd3a93617
https://doi.org/10.1006/abio.1999.4306
https://doi.org/10.1006/abio.1999.4306
Autor:
Dennis E. Epps, J.S. Harris, George W. Melchior, Ferenc J. Kezdy, K.A. Greenlee, R.G. Ulrich, T.S. Moll, Christine Castle, Jed F. Fisher, C.K. Marschke
Publikováno v:
Chemistry and Physics of Lipids. 77:51-63
A continuous recording fluorescence assay was developed for cholesteryl ester transfer protein (CETP). The assay measures the increase in fluorescence accompanying the relocation of fluorescent lipids, cholesteryl esters and triglycerides, from a don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaf6cd0468dbd94f008f5ccc487bfb6
https://doi.org/10.1016/0009-3084(95)02454-q
https://doi.org/10.1016/0009-3084(95)02454-q
Publikováno v:
Biochemistry. 34:3851-3857
The behavior of multilamellar liposomes of 2,3-dipalmitoyl-sn-glycero-1-phosphocholine (DPPC) was studied by differential scanning calorimetry (DSC) in the presence of < or = 5 mol % of the amphiphilic solutes methyl oleate, cholesterol, pregnenolone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd648c28a0cfd4c087237f3334da2b28
https://doi.org/10.1021/bi00011a043
https://doi.org/10.1021/bi00011a043