Výsledky vyhledávání - "Dennis E Hallahan"

Akademický článek

A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.

Autor: Xiaoyu Jiang, Liya Yuan, John A Engelbach, Jeremy Cates, Carlos J Perez-Torres, Feng Gao, Dinesh Thotala, Robert E Drzymala, Robert E Schmidt, Keith M Rich, Dennis E Hallahan, Joseph J H Ackerman, Joel R Garbow

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139596 (2015)

To develop a Gamma Knife-based mouse model of late time-to-onset, cerebral radiation necrosis (RN) with serial evaluation by magnetic resonance imaging (MRI) and histology.Mice were irradiated with the Leksell Gamma Knife® (GK) PerfexionTM (Elekta A

Externí odkaz: https://doaj.org/article/428517677bd24ba99a26554d2f565fac

Zobrazit plný text záznamu

Akademický článek

Autotaxin inhibition with PF8380 enhances the radiosensitivity of human and murine glioblastoma cell lines

Autor: Sandeep R Bhave, David YA dadey, Rowan M Karvas, Daniel J Ferraro, Rama P Kotipatruni, Jerry J Jaboin, Andrew N Hallahan, Todd A DeWees, Amanda G Linkous, Dennis E Hallahan, Dinesh eThotala

Publikováno v: Frontiers in Oncology, Vol 3 (2013)

Purpose: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo and radiotherapy. Autotaxin (ATX) is over expressed in various cancers including GBM and is implicated in

Externí odkaz: https://doaj.org/article/022b308e46e34e068463337283015032

Zobrazit plný text záznamu

Akademický článek

Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models.

Autor: Dinesh Thotala, Jeffrey M Craft, Daniel J Ferraro, Rama P Kotipatruni, Sandeep R Bhave, Jerry J Jaboin, Dennis E Hallahan

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69688 (2013)

Lung cancer remains the leading cause of cancer deaths in the United States and the rest of the world. The advent of molecularly directed therapies holds promise for improvement in therapeutic efficacy. Cytosolic phospholipase A2 (cPLA2) is associate

Externí odkaz: https://doaj.org/article/c40d2f3f2e064989a4bf12c974ab77ae

Zobrazit plný text záznamu

Akademický článek

Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

Autor: Stephen M Schleicher, Dinesh K Thotala, Amanda G Linkous, Rong Hu, Kathleen M Leahy, Eugenia M Yazlovitskaya, Dennis E Hallahan

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22182 (2011)

Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA(2)) is a molecular target for radiosensitizing cancer

Externí odkaz: https://doaj.org/article/be184eebf7ae4b8ab66ebf0c09a38f7d

Zobrazit plný text záznamu

Akademický článek

Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy

Autor: Abhay K. Singh, David YA Dadey, Michael J. Rau, James Fitzpatrick, Harendra K. Shah, Minakshi Saikia, Reid Townsend, Dinesh Thotala, Dennis E. Hallahan, Vaishali Kapoor

Publikováno v: Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115341- (2023)

Non-small-cell lung cancer (NSCLC) and glioblastoma (GB) have poor prognoses. Discovery of new molecular targets is needed to improve therapy. Tax interacting protein 1 (TIP1), which plays a role in cancer progression, is overexpressed and radiation-

Externí odkaz: https://doaj.org/article/bcfc1e7c5a7a46b89b54fb77729c4b77

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání