Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Dennis E Discher"'
Autor:
Brandon H Hayes, Mai Wang, Hui Zhu, Steven H Phan, Lawrence J Dooling, Jason C Andrechak, Alexander H Chang, Michael P Tobin, Nicholas M Ontko, Tristan Marchena, Dennis E Discher
Publikováno v:
eLife, Vol 12 (2024)
Solid tumors generally exhibit chromosome copy number variation, which is typically caused by chromosomal instability (CIN) in mitosis. The resulting aneuploidy can drive evolution and associates with poor prognosis in various cancer types as well as
Externí odkaz:
https://doaj.org/article/8b917f509d2c4d10a4dbad3350216fa9
Autor:
Nisha G Sosale, Irena I Ivanovska, Richard K Tsai, Joe Swift, Jake W Hsu, Cory M Alvey, Philip W Zoltick, Dennis E Discher
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self
Externí odkaz:
https://doaj.org/article/460d66d0a2cf46ebae8bc9565a6968bc
Autor:
Zhengyu Ma, David N LeBard, Sharon M Loverde, Kim A Sharp, Michael L Klein, Dennis E Discher, Terri H Finkel
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112292 (2014)
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dime
Externí odkaz:
https://doaj.org/article/9a652f5d42594c929ea0eba413fb5919
Autor:
Aae Suzuki, Jae-Won Shin, Yuhuan Wang, Sang H Min, Morty Poncz, John K Choi, Dennis E Discher, Chris L Carpenter, Lurong Lian, Liang Zhao, Yangfeng Wang, Charles S Abrams
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69315 (2013)
RhoA plays a multifaceted role in platelet biology. During platelet development, RhoA has been proposed to regulate endomitosis, proplatelet formation, and platelet release, in addition to having a role in platelet activation. These processes were pr
Externí odkaz:
https://doaj.org/article/a4b4b9ddf9e04631b1c81f7f3a07ad50
Autor:
Charlotte R. Pfeifer, Michael P. Tobin, Sangkyun Cho, Manasvita Vashisth, Lawrence J. Dooling, Lizeth Lopez Vazquez, Emma G. Ricci-De Lucca, Keiann T. Simon, Dennis E. Discher
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 129-143 (2022)
Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B filaments stably interact with the n
Externí odkaz:
https://doaj.org/article/24f2d772cf1546849c968f505a41ab11
Publikováno v:
Nature Methods. 19:1064-1071
Publikováno v:
Chromosoma.
Publikováno v:
Journal of Cell Biology. 222
The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids with a poorly understood interfacial tension γ that determines how FDs
Autor:
Brandon H. Hayes, Peter Kuangzheng Zhu, Mai Wang, Charlotte R. Pfeifer, Yuntao Xia, Steven Phan, Jason C. Andrechak, Junhong Du, Michael P. Tobin, Alisya Anlas, Lawrence J. Dooling, Manasvita Vashisth, Jerome Irianto, Michael A. Lampson, Dennis E. Discher
Publikováno v:
Journal of Cell Science.
A cell's mechanical environment can have many effects, but whether it impacts a cell's DNA sequence has remained unclear. To investigate this, we developed a live-cell method to measure changes in chromosome numbers. We edited constitutive genes with
Autor:
Lawrence J. Dooling, Jason C. Andrechak, Brandon H. Hayes, Siddhant Kadu, William Zhang, Ruby Pan, Manasvita Vashisth, Jerome Irianto, Cory M. Alvey, Leyuan Ma, Dennis E. Discher
Publikováno v:
Nature Biomedical Engineering.