Zobrazeno 1 - 10 of 208 pro vyhledávání: '"Dennis E, Hruby"'
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Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations
Autor: Gaëlle Frenois-Veyrat, Franck Gallardo, Olivier Gorgé, Elie Marcheteau, Olivier Ferraris, Artem Baidaliuk, Anne-Laure Favier, Cécile Enfroy, Xavier Holy, Jérémy Lourenco, Rhéa Khoury, Flora Nolent, Douglas W. Grosenbach, Dennis E. Hruby, Audrey Ferrier, Frédéric Iseni, Etienne Simon-Loriere, Jean-Nicolas Tournier
Publikováno v: Nature microbiology. 7(12)
The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. We isolated and sequenced a virus from the first clinical MPXV case diagnosed in France (May 2022). We report that tecovirimat (ST-246), a US Food and Drug Ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb5665a4d1ab240871608861f4feca3
https://pubmed.ncbi.nlm.nih.gov/36344621
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4
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Autor: Hugh Adler, Susan Gould, Paul Hine, Luke B Snell, Waison Wong, Catherine F Houlihan, Jane C Osborne, Tommy Rampling, Mike BJ Beadsworth, Christopher JA Duncan, Jake Dunning, Tom E Fletcher, Ewan R Hunter, Michael Jacobs, Saye H Khoo, William Newsholme, David Porter, Robert J Porter, Libuše Ratcliffe, Matthias L Schmid, Malcolm G Semple, Anne J Tunbridge, Tom Wingfield, Nicholas M Price, Mike Abouyannis, Asma Al-Balushi, Stephen Aston, Robert Ball, Nicholas J Beeching, Thomas J Blanchard, Ffion Carlin, Geraint Davies, Angela Gillespie, Scott R Hicks, Marie-Claire Hoyle, Chinenye Ilozue, Luke Mair, Suzanne Marshall, Anne Neary, Emmanuel Nsutebu, Samantha Parker, Hannah Ryan, Lance Turtle, Chris Smith, Jon van Aartsen, Naomi F Walker, Stephen Woolley, Anu Chawla, Ian Hart, Anna Smielewska, Elizabeth Joekes, Cathryn Benson, Cheryl Brindley, Urmi Das, Chin K Eyton-Chong, Claire Gnanalingham, Clare Halfhide, Beatriz Larru, Sarah Mayell, Joanna McBride, Claire Oliver, Princy Paul, Andrew Riordan, Lekha Sridhar, Megan Storey, Audrey Abdul, Jennifer Abrahamsen, Breda Athan, Sanjay Bhagani, Colin S Brown, Oliver Carpenter, Ian Cropley, Kerrie Frost, Susan Hopkins, Jessica Joyce, Lucy Lamb, Adrian Lyons, Tabitha Mahungu, Stephen Mepham, Edina Mukwaira, Alison Rodger, Caroline Taylor, Simon Warren, Alan Williams, Debbie Levitt, Denise Allen, Jill Dixon, Adam Evans, Pauline McNicholas, Brendan Payne, D Ashley Price, Uli Schwab, Allison Sykes, Yusri Taha, Margaret Ward, Marieke Emonts, Stephen Owens, Alina Botgros, Sam T Douthwaite, Anna Goodman, Akish Luintel, Eithne MacMahon, Gaia Nebbia, Geraldine O'Hara, Joseph Parsons, Ashwin Sen, Daniel Stevenson, Tadgh Sullivan, Usman Taj, Claire van Nipsen tot Pannerden, Helen Winslow, Ewa Zatyka, Ekene Alozie-Otuka, Csaba Beviz, Yusupha Ceesay, Latchmin Gargee, Morloh Kabia, Hannah Mitchell, Shona Perkins, Mingaile Sasson, Kamal Sehmbey, Federico Tabios, Neil Wigglesworth, Emma J Aarons, Tim Brooks, Matthew Dryden, Jenna Furneaux, Barry Gibney, Jennifer Small, Elizabeth Truelove, Clare E Warrell, Richard Firth, Gemma Hobson, Christopher Johnson, Alison Dewynter, Sebastian Nixon, Oliver Spence, Joachim J Bugert, Dennis E Hruby
Background Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e287fd12f14777099c17c4a2cd3957
https://ora.ox.ac.uk/objects/uuid:b4702035-0ad4-4de0-a058-16fc519f15ab
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5
An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications
Autor: Douglas W. Grosenbach, Paul G Long, Dennis E. Hruby, Andrew T. Russo, Candace Lovejoy, Ingrid Meara, Biswajit Maiti, Kady M. Honeychurch, Jarasvech Chinsangaram
Publikováno v: Expert Review of Anti-infective Therapy. 19:331-344
Tecovirimat (TPOXX®; ST-246) was approved for the treatment of symptomatic smallpox by the USFDA in July of 2018 and has been stockpiled by the US government for use in a smallpox outbreak. While there has not been a reported case of smallpox since
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dc2def56381c858bab7f5fa34ac3a6
https://doi.org/10.1080/14787210.2020.1819791
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6
Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge
Autor: Catherine B. Bigger, Andrew T. Russo, Aklile Berhanu, Dennis E. Hruby, Jon Prigge, Douglas W. Grosenbach, Peter Silvera
Publikováno v: Vaccine
Naturally occurring smallpox has been eradicated but research stocks of variola virus (VARV), the causative agent of smallpox, still exist in secure laboratories. Clandestine stores of the virus or resurrection of VARV via synthetic biology are possi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3e432571b3c73936f835d82b13ce7c
https://doi.org/10.1016/j.vaccine.2019.10.049
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7
Akademický článek
Development of ST-246® for Treatment of Poxvirus Infections
Autor: Dennis E. Hruby, Janet M. Leeds, Robert Jordan, Shanthakumar Tyavanagimatt
Publikováno v: Viruses, Vol 2, Iss 11, Pp 2409-2435 (2010)
ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was discovered as part of a high throughput screen designed to identify inhibitors of vaccinia virus-ind
Externí odkaz: https://doaj.org/article/8351d4bf79d846408483ab895a1ef70f
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8
Akademický článek
BiZyme: A Novel Fusion Protein-Mediating Selection of Vaccinia Virus Recombinants by Fluorescence and Antibiotic Resistance
Autor: Scott G. Hansen, Torrey A. Cope, Dennis E. Hruby
Publikováno v: BioTechniques, Vol 32, Iss 5, Pp 1178-1187 (2002)
Recombinant vaccinia virus is a useful and powerful tool for the expression and study of foreign genes. Methods that are currently available for the selection of vaccinia virus recombinants include the restoration of viral plaque-forming phenotype, t
Externí odkaz: https://doaj.org/article/2b83ac9988f74462b1f615746ecfedd9
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9
Akademický článek
Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
Autor: Adams Amantana, Yali Chen, Shanthakumar R Tyavanagimatt, Kevin F Jones, Robert Jordan, Jarasvech Chinsangaram, Tove C Bolken, Janet M Leeds, Dennis E Hruby
Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61514 (2013)
Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest Tmax of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4
Externí odkaz: https://doaj.org/article/f4abcb9907704df6be4a8674f410129f
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