Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dennis Das, Gupta"'
Publikováno v:
European Journal of Immunology. 52:1680-1683
IRF4 knock-out cells do not differentiate properly into T helper subsets 2, 9, and 17. Compared to WT IRF4 point mutation L116R shows differentially expressed key cytokines. While amounts Th2 and Th17 cells are decreased, there is a strong induction
Autor:
Dennis Das Gupta, Michael Lohoff
Publikováno v:
European Journal of Immunology. 53
Autor:
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Bärbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jäck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
The processes leading from disturbed B cell development to adult B cell progenitor acute lymphoblastic leukemia (BCP-ALL) are poorly understood. Here, we describe Irf4−/− mice as prone to developing BCP-ALL with age. Irf4−/− preB-I cells exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::019b2ff723d80862b81ffa903579885c
https://doi.org/10.1101/2022.02.16.480573
https://doi.org/10.1101/2022.02.16.480573
Autor:
Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, Dennis Das Gupta, Heike Hirseland, Daniel Staudenraus, Bärbel Camara, Kirsten Volland, Véronique Hefter, Siddhesh Sapre, Verena Krähling, Helena Müller-Kräuter, Henrik E. Mei, Christian Keller, Michael Lohoff
A third mRNA-based “booster” vaccination is the favored strategy to maintain protection against SARS-CoV-2 infection. Yet, significant waning of specific immunity within six months after 2nd vaccination, along with higher incidence of breakthroug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d8160cd519cec4fc425887a79c9d7b0
https://doi.org/10.1101/2022.02.10.22270733
https://doi.org/10.1101/2022.02.10.22270733
Autor:
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Bärbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M. Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jäck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
Publikováno v:
Cell death and differentiation. 29(11)
The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4−/− mice as prone to developing BCP-ALL with age. Irf4−/− preB-I cells e
Autor:
Addi J, Romero-Olmedo, Axel Ronald, Schulz, Svenja, Hochstätter, Dennis Das, Gupta, Heike, Hirseland, Daniel, Staudenraus, Bärbel, Camara, Kirsten, Volland, Véronique, Hefter, Siddhesh, Sapre, Verena, Krähling, Helena, Müller-Kräuter, Ho-Ryun, Chung, Henrik E, Mei, Christian, Keller, Michael, Lohoff
Publikováno v:
The Lancet Infectious Diseases. 22:588-589
Autor:
Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, Dennis Das Gupta, Iiris Virta, Heike Hirseland, Daniel Staudenraus, Bärbel Camara, Carina Münch, Véronique Hefter, Siddhesh Sapre, Verena Krähling, Helena Müller-Kräuter, Marek Widera, Henrik E. Mei, Christian Keller, Michael Lohoff
Publikováno v:
Nature microbiology
Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were g
Autor:
Frederik Helmprobst, Hans-Martin Jäck, Andreas Neubauer, Maria Bieringer, Thorsten Stiewe, Marco Mernberger, Christoph Paul, Lisa Menke, Uta-Maria Bauer, Dennis Das Gupta, Nadine Bollig, Axel Pagenstecher, Federico Marini, Michael Wanzel, Andreas Burchert, Andrea Nist, Hartmann Raifer, Daniel Staudenraus, Matthias Klein, Michael Lohoff, Edith Roth, Bärbel Camara, Malte Buchholz, Patrick Daum, Tobias Bopp
How disturbances of B cell development provoke adult B acute lymphoblastic leukemia (B-ALL) remains poorly understood. Here we describe Irf4–/– mice as prone to developing B-ALL with age. Irf4–/– pro/preB cells exhibited impaired differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bafe58b8d57b37c741a4b4717fe64ab7
https://doi.org/10.21203/rs.3.rs-271184/v1
https://doi.org/10.21203/rs.3.rs-271184/v1
Autor:
Melanie Grusdat, Ying Chen, Dennis Das Gupta, Tak W. Mak, Rashi Halder, Sophie Farinelle, Christian Jäger, Johannes Meiser, Luana Guerra, Lynn Bonetti, Gordon S. Duncan, Anouk Ewen, Lisa Schlicker, Paul Wilmes, Karsten Hiller, Jillian Haight, Myriam P. Merz, Yannic Nonnenmacher, Michael Lohoff, Rabia Taskesen, Vasilis Vasiliou, Markus Ollert, Davide G. Franchina, Carole Binsfeld, Isaac S. Harris, Christiane B. Knobbe-Thomsen, Oliver Hunewald, Henry Kurniawan, Dirk Brenner, Jonathan D. Turner, Leticia Soriano Baguet, Catherine Dostert
Publikováno v:
Cell Metab
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
936.e7
Cell metabolism
United States
Kurniawan, H, Franchina, D G, Guerra, L, Bonetti, L, Baguet, L S, Grusdat, M, Schlicker, L, Hunewald, O, Dostert, C, Merz, M P, Binsfeld, C, Duncan, G S, Farinelle, S, Nonnenmacher, Y, Haight, J, Das Gupta, D, Ewen, A, Taskesen, R, Halder, R, Chen, Y, Jäger, C, Ollert, M, Wilmes, P, Vasiliou, V, Harris, I S, Knobbe-Thomsen, C B, Turner, J D, Mak, T W, Lohoff, M, Meiser, J, Hiller, K & Brenner, D 2020, ' Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function ', Cell Metabolism, vol. 31, no. 5, pp. 920-936.e7 . https://doi.org/10.1016/j.cmet.2020.03.004
Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network (1CMet) essential for effector T cell (Teff) responses. However, serine's f