Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Dennis D.M. O'Leary"'
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 560-571 (2016)
The subventricular zone (SVZ) provides a specialized neurogenic microenvironment for proliferation and aggregation of basal progenitors (BPs). Our study reveals a mechanism for the aggregation of BPs within the SVZ required for their proliferation an
Externí odkaz:
https://doaj.org/article/9dfbe1e14ef74ef4970dba9ec49f7f0f
Publikováno v:
Developmental Biology. 412:139-147
Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1tm1(cre)S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6f78329419910943de0fc173752263
https://doi.org/10.1016/j.ydbio.2016.02.011
https://doi.org/10.1016/j.ydbio.2016.02.011
Autor:
Shen-Ju Chou, Andreas Zembrzycki, Chia-Fang Wang, Carlos G. Perez-Garcia, Dennis D.M. O'Leary
Publikováno v:
Proceedings of the National Academy of Sciences. 112:6736-6741
Current knowledge suggests that cortical sensory area identity is controlled by transcription factors (TFs) that specify area features in progenitor cells and subsequently their progeny in a one-step process. However, how neurons acquire and maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080c7cbf9cebf023096ae24d285be8ee
https://doi.org/10.1073/pnas.1424440112
https://doi.org/10.1073/pnas.1424440112
Autor:
Yanmei Lu, Zhuhao Wu, Courtney Easley-Neal, Philip E. Hass, Marc Tessier-Lavigne, David J. Simon, Alexander Jaworski, Robby M. Weimer, Cynthia Duggan, Dara Y. Kallop, Olav Olsen, Sarah Huntwork-Rodriguez, Kentaro Takeda, Todd McLaughlin, Dennis D.M. O'Leary
Publikováno v:
The Journal of Neuroscience. 34:6438-6447
In the developing brain, initial neuronal projections are formed through extensive growth and branching of developing axons, but many branches are later pruned to sculpt the mature pattern of connections. Despite its widespread occurrence, the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814b764cbbc8806bbdd5aa1c5d8275d5
https://doi.org/10.1523/jneurosci.3522-13.2014
https://doi.org/10.1523/jneurosci.3522-13.2014
Autor:
Daichi Kawaguchi, Ji Yong Kang, Zheng Xiang, Dennis D.M. O'Leary, Lei Wang, Paul A. Slesinger, Irene Coin
Publikováno v:
Neuron. 80:358-370
Summary Optical control of protein function provides excellent spatial-temporal resolution for studying proteins in situ. Although light-sensitive exogenous proteins and ligands have been used to manipulate neuronal activity, a method for optical con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc489c9cf895650bc7301f53c65b184
https://doi.org/10.1016/j.neuron.2013.08.016
https://doi.org/10.1016/j.neuron.2013.08.016
Autor:
Jing Yang, Rami N. Hannoush, David J. Simon, Dara Y. Kallop, Robby M. Weimer, Marc Tessier-Lavigne, Dennis D.M. O'Leary, Todd McLaughlin, Karen Stanger
Publikováno v:
The Journal of Neuroscience. 32:17540-17553
Axon degeneration initiated by trophic factor withdrawal shares many features with programmed cell death, but many prior studies discounted a role for caspases in this process, particularly Caspase-3. Recently, Caspase-6 was implicated based on pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb958efa46d05fee0d128f5f7b4644df
https://doi.org/10.1523/jneurosci.3012-12.2012
https://doi.org/10.1523/jneurosci.3012-12.2012
Autor:
Alejandro Ocampo, Pradeep Reddy, David Lam, Marie N. Krause, Li Ma, Robert Morey, Min-Zu Wu, Yuriko Hishida, Aitor Aguirre, Juan Carlos Izpisua Belmonte, Ignacio Sancho-Martinez, Yun Xia, Dennis D.M. O'Leary, Eric Vazquez-Ferrer, Geoffrey M. Wahl, Andreas Zembrzycki, Emmanuel Nivet, Inder M. Verma, Louise C. Laurent, Concepcion Rodriguez Esteban, Tomoaki Hishida, Olaf Ansorge, Ilir Dubova
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2016, 7, ⟨10.1038/ncomms10743⟩
Nature Communications, 2016, 7, ⟨10.1038/ncomms10743⟩
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Sancho-Martinez, I, Nivet, E, Xia, Y, Hishida, T, Aguirre, A, Ocampo, A, Ma, L, Morey, R, Krause, M N, Zembrzycki, A, Ansorge, O, Vazquez-Ferrer, E, Dubova, I, Reddy, P, Lam, D, Hishida, Y, Wu, M-Z, Esteban, C R, O'Leary, D, Wahl, G M, Verma, I M, Laurent, L C & Izpisua Belmonte, J C 2016, ' Establishment of human iPSC-based models for the study and targeting of glioma initiating cells ', Nature Communications, vol. 7, 10743 . https://doi.org/10.1038/ncomms10743
Sancho-Martinez, Ignacio; Nivet, Emmanuel; Xia, Yun; Hishida, Tomoaki; Aguirre, Aitor; Ocampo, Alejandro; et al.(2016). Establishment of human iPSC-based models for the study and targeting of glioma initiating cells.. Nature communications, 7(1), 10743. doi: 10.1038/ncomms10743. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/70p4r690
Nature Communications, Nature Publishing Group, 2016, 7, ⟨10.1038/ncomms10743⟩
Nature Communications, 2016, 7, ⟨10.1038/ncomms10743⟩
Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Sancho-Martinez, I, Nivet, E, Xia, Y, Hishida, T, Aguirre, A, Ocampo, A, Ma, L, Morey, R, Krause, M N, Zembrzycki, A, Ansorge, O, Vazquez-Ferrer, E, Dubova, I, Reddy, P, Lam, D, Hishida, Y, Wu, M-Z, Esteban, C R, O'Leary, D, Wahl, G M, Verma, I M, Laurent, L C & Izpisua Belmonte, J C 2016, ' Establishment of human iPSC-based models for the study and targeting of glioma initiating cells ', Nature Communications, vol. 7, 10743 . https://doi.org/10.1038/ncomms10743
Sancho-Martinez, Ignacio; Nivet, Emmanuel; Xia, Yun; Hishida, Tomoaki; Aguirre, Aitor; Ocampo, Alejandro; et al.(2016). Establishment of human iPSC-based models for the study and targeting of glioma initiating cells.. Nature communications, 7(1), 10743. doi: 10.1038/ncomms10743. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/70p4r690
Glioma tumour-initiating cells (GTICs) can originate upon the transformation of neural progenitor cells (NPCs). Studies on GTICs have focused on primary tumours from which GTICs could be isolated and the use of human embryonic material. Recently, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e493e15089e7aef841d55a2e81b34ded
https://hal.archives-ouvertes.fr/hal-01477820
https://hal.archives-ouvertes.fr/hal-01477820
Autor:
Dennis D.M. O'Leary, Adam M. Stocker
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149900 (2016)
PLoS ONE
PLoS ONE
Establishing appropriate area patterning in the neocortex is a critical developmental event, and transcription factors whose expression is graded across the developing neural axes have been implicated in this process. While previous reports suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa98b8c23458273897a7f1cd521c28fa
http://europepmc.org/articles/PMC4762677?pdf=render
http://europepmc.org/articles/PMC4762677?pdf=render
Publikováno v:
The Journal of Neuroscience. 32:4755-4761
Approximately one in five neurons is GABAergic in many neocortical areas and species, forming a critical balance between inhibition and excitation in adult circuits. During development, cortical GABAergic neurons are generated in ventral telencephalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c5e68a44c96aa32debd478fd983ed2
https://doi.org/10.1523/jneurosci.6412-11.2012
https://doi.org/10.1523/jneurosci.6412-11.2012
Autor:
Setsuko Sahara, Andreas Zembrzycki, Shen-Ju Chou, Michael P. Stryker, Adam M. Stocker, Axel Leingärtner, Dennis D.M. O'Leary, Valery A. Kalatsky, Scott R. May
Publikováno v:
eLife, Vol 4 (2015)
Zembrzycki, A, Stocker, A, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, S, Stryker, M & O'Leary, D DM 2015, ' Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ', eLife, vol. 4, no. 0, e11416 . https://doi.org/10.7554/eLife.11416
eLife
Zembrzycki, A, Stocker, A, Leingärtner, A, Sahara, S, Chou, S-J, Kalatsky, V, May, S, Stryker, M & O'Leary, D DM 2015, ' Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas. ', eLife, vol. 4, no. 0, e11416 . https://doi.org/10.7554/eLife.11416
eLife
In mammals, the neocortical layout consists of few modality-specific primary sensory areas and a multitude of higher order ones. Abnormal layout of cortical areas may disrupt sensory function and behavior. Developmental genetic mechanisms specify pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5dd66348b91438803a7e9d02e0bec6
https://elifesciences.org/articles/11416
https://elifesciences.org/articles/11416