Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dennis D. Pietronigro"'
Publikováno v:
Journal of Neuro-Oncology. 62:251-258
Intratumoral (IT) administration of DTI-015 (BCNU in 100% ethanol) utilizes solvent facilitated perfusion for the treatment of tumors. RIF-1 tumors were treated by IT injection of either ethanol alone or 0.05–1.0 mg of DTI-015 or by iv injection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5ef8b2d217a09067e5579791b22947
https://doi.org/10.1023/a:1023383717833
https://doi.org/10.1023/a:1023383717833
Autor:
Victor A. Levin, Emilio M. Nardone, Samuel J. Hassenbusch, Norman E. Leeds, Dennis D. Pietronigro
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 1, Pp 9-16 (2003)
DTI-015 (BCNU in 100% ethanol) utilizes solvent facilitated perfusion for the intratumoral treatment of gliomas. The ethanol solvent vehicle facilitates a rapid and thorough saturation of the tumor with the dissolved anticancer agent BCNU. We conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbb5208d3574a1a6f7e7fe7e6d9a3a1
Autor:
Harry B. Demopoulos, Vincent DeCrescito, Eugene S. Flamm, John J. Tomasula, Dennis D. Pietronigro
Publikováno v:
Central Nervous System Trauma. 2:85-90
The development of permanent parapelegia in spinal injured cats is accompanied by a large progressive decline in total ascorbic acid (AA) and a transient increase in oxidized (AAox) ascorbate. Since AA is involved in a variety of processes required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8832b452fc1741624737695fab3539e9
https://doi.org/10.1089/cns.1985.2.85
https://doi.org/10.1089/cns.1985.2.85
Publikováno v:
Journal of Neurochemistry. 41:1072-1076
Feline spinal cord contains 0.97 mM ascorbic acid, as measured by the dinitrophenylhydrazine method. Greater than 90% is maintained in the reduced form. When functioning normally, the CNS conserves its ascorbic acid with a turnover rate of 2% per h.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060ba80d76dd862608d54b8e2208fd69
https://doi.org/10.1111/j.1471-4159.1983.tb09053.x
https://doi.org/10.1111/j.1471-4159.1983.tb09053.x
Autor:
Myron L. Seligman, Harry B. Demopoulos, Dennis D. Pietronigro, V. DeCrescito, J. J. Tomasula, Eugene S. Flamm
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 60:1415-1424
The hypothesis that pathologic free-radical reactions are initiated and catalyzed in the major central nervous system (CNS) disorders has been further supported by the current acute spinal cord injury work that has demonstrated the appearance of spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ace4d8f1ce256909d0175fbda8b8d5
https://doi.org/10.1139/y82-210
https://doi.org/10.1139/y82-210
Publikováno v:
Journal of the American College of Toxicology. 2:173-184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56054f243635382a0b89af775e894c5a
https://doi.org/10.3109/10915818309140700
https://doi.org/10.3109/10915818309140700
Publikováno v:
Biochemical pharmacology. 32(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1166ac43c8ea80ebd0a9352dcd2ee9
https://pubmed.ncbi.nlm.nih.gov/6860363
https://pubmed.ncbi.nlm.nih.gov/6860363
Publikováno v:
Brain research. 333(1)
Rat and feline brain and feline spinal cord were examined for the presence of semidehydroascorbate reductase (EC 1.6.5.4) and dehydroascorbate reductase (EC 1.8.5.1). Semidehydroascorbate reductase (SDAR), as monitored by both ascorbyl radical-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c681281394549d446b932f8b231047b
https://pubmed.ncbi.nlm.nih.gov/3995284
https://pubmed.ncbi.nlm.nih.gov/3995284
Publikováno v:
Journal of neurosurgery. 65(5)
✓ In an attempt to improve glioma management, an animal model was developed to evaluate the therapeutic efficacy of intra-arterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Furthermore, the model was used to study the antitumor activity of D,L-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549ebb0a8d9b381445a3426aa9c28b13
https://pubmed.ncbi.nlm.nih.gov/3095505
https://pubmed.ncbi.nlm.nih.gov/3095505
Publikováno v:
Neurosurgery. 23(4)
The in vivo uptake and metabolism of radiolabeled putrescine was examined in two glioma models: (a) the T9 gliosarcoma in the CD Fischer rat and (b) the U-87 MG human glioblastoma in the athymic (nude) mouse. Autoradiography after parenteral administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0a742dcfdde6814e290271db84d5fe
https://pubmed.ncbi.nlm.nih.gov/3264387
https://pubmed.ncbi.nlm.nih.gov/3264387