Frontiers in Optics and Photonics

Autor: Federico Capasso, Dennis Couwenberg

This book provides a cutting-edge research overview on the latest developments in the field of Optics and Photonics. All chapters are authored by the pioneers in their field and will cover the developments in Quantum Photonics, Optical properties of

Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones

Autor: Hendrik Timmerman, Hildegard Boss, Margaretha Van der Mey, Geert Jan Sterk, Kees Goubitz, Armin Hatzelmann, Henk Schenk, Dennis Couwenberg

Publikováno v: Journal of Medicinal Chemistry, 45, 2526-33. American Chemical Society
der Van Mey, M, Boss, H, Couwenberg, D, Hatzelmann, A, Sterk, G J, Goubitz, K, Schenk, H & Timmerman, H 2002, ' Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra-and cis-hexahydrophthalazinones ', Journal of Medicinal Chemistry, vol. 45, pp. 2526-33 . https://doi.org/10.1021/jm0110338
Journal of Medicinal Chemistry, 45, 2526-2533. American Chemical Society

Recently, we reported that 4-catechol-substituted cis-(+/-)-4a,5,6,7,8,8a-hexa- and cis-(+/-)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones show potent inhibition of phosphodiesterase (PDE4) activity, while the corresponding trans racemic mixtures exhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ea68cc0940f988663a1ef1f6e0417
https://research.vu.nl/en/publications/2fdf851e-0f3d-4310-8869-80246845a738