Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Dennis C. Mays"'
Autor:
James J. Lipsky, William J. Sandborn, Philip W. Lowry, Curtis L. Franklin, William J. Tremaine, Carlton W. Thomas, Dennis C. Mays, Amy L. Weaver, Gennett M. Myhre
Publikováno v:
Inflammatory Bowel Diseases. 9:237-245
Mean corpuscular volume may correlate with erythrocyte 6-thioguanine nucleotide concentrations in patients treated with azathioprine and 6-mercaptourine. We conducted a study of 166 patients with inflammatory bowel disease treated with azathioprine o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cd64fc0ca3f292438e68aa127769b7
https://doi.org/10.1097/00054725-200307000-00004
https://doi.org/10.1097/00054725-200307000-00004
Autor:
Joseph A. Murray, Ross A. Dierkhising, Laurence J. Egan, Dennis C. Mays, Gennett M. Myhre, Patricia P. Kammer
Publikováno v:
Alimentary Pharmacology & Therapeutics. 17:1521-1528
Summary Background: The rate of metabolic inactivation of proton-pump inhibitors is determined by polymorphisms of CYP2C19. It is not known if CYP2C19 variant alleles affect responses to proton-pump inhibitor therapy in gastro-oesophageal reflux dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f0e952cca2902188ac98e6e8aaf427
https://doi.org/10.1046/j.1365-2036.2003.01645.x
https://doi.org/10.1046/j.1365-2036.2003.01645.x
Autor:
Curtis L. Franklin, Philip W. Lowry, M. Gennett Pike, James J. Lipsky, William J. Sandborn, Dennis C. Mays
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 757:1-9
The conversion of the cytotoxic and immunosuppressive 6-mercaptopurine (6MP) to the active 6-thioguanine nucleotides (6TGN) is necessary for clinical efficacy of 6MP and its prodrug azathioprine. Another metabolite, 6-methylmercaptopurine nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa801767705c5372f287d24a34dbafe
https://doi.org/10.1016/s0378-4347(00)00513-2
https://doi.org/10.1016/s0378-4347(00)00513-2
Publikováno v:
Biochemical Pharmacology. 61:537-545
Extensive use for disulfiram (DSF) has been found in the aversion therapy treatment of recovering alcoholics. Although it is known to irreversibly inhibit hepatic aldehyde dehydrogenase (ALDH), the specific mechanism of in vivo inhibition of the enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab631a6199a5529e1985112c7083a20d
https://doi.org/10.1016/s0006-2952(00)00586-4
https://doi.org/10.1016/s0006-2952(00)00586-4
Publikováno v:
Inflammatory Bowel Diseases. 6:286-289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39e0f49e6789b2543af5c7078060d2e1
https://doi.org/10.1097/00054725-200011000-00005
https://doi.org/10.1097/00054725-200011000-00005
Publikováno v:
Rapid Communications in Mass Spectrometry. 14:918-923
Disulfiram has been used clinically as an aversion therapy treatment for recovering alcoholics. One of its metabolites, S-methyl-N, N-diethylthiocarbamoyl sulfoxide (MeDTC-SO), is currently believed by some to be the active metabolite in vivo. We dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae2f57919584b9fc171b0d0fecbe6e4
https://doi.org/10.1002/(sici)1097-0231(20000530)14:10<918::aid-rcm966>3.0.co
https://doi.org/10.1002/(sici)1097-0231(20000530)14:10<918::aid-rcm966>3.0.co
Autor:
Alan R. Zinsmeister, William J. Tremaine, Jonathan A. Leighton, M G Pike, Laurence J. Egan, James J. Lipsky, William J. Sandborn, Dennis C. Mays
Publikováno v:
Alimentary Pharmacology & Therapeutics. 13:1597-1604
Background and aims: The optimum initial dose of methotrexate for steroid-requiring inflammatory bowel disease is not known. Aim: To compare directly the efficacy and toxicity of methotrexate 15 and 25 mg/week, and to explore the value of methotrexat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c8abdd1eadea388cd83c8a9107ff76
https://doi.org/10.1046/j.1365-2036.1999.00667.x
https://doi.org/10.1046/j.1365-2036.1999.00667.x
Autor:
Richard N. Fedorak, Christi S. Kleoudis, Kim L. Isaacs, M.Gennette Pike, Brian G. Feagan, Susan Gordon, John W.D. McDonald, Stephen B. Hanauer, Charles A. Sninsky, William J. Tremaine, Lloyd R. Sutherland, Robert H. Murdock, Dennis C. Mays, James J. Lipsky, William J. Sandborn, Douglas C. Wolf, Stephan R. Targan
Publikováno v:
Gastroenterology. 117:527-535
Background & Aims: Azathioprine is effective for Crohn's disease but acts slowly. A loading dose may decrease the time to response. Methods: A placebo-controlled study was conducted in patients with active Crohn's disease despite prednisone treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297ed85a047a1f11d107a1745538aa19
https://doi.org/10.1016/s0016-5085(99)70445-2
https://doi.org/10.1016/s0016-5085(99)70445-2
Autor:
David J. McKean, James J. Lipsky, William J. Sandborn, Laurence J. Egan, Dennis C. Mays, M G Pike, Michael P. Bell, Cathy Huntoon
Publikováno v:
Journal of Biological Chemistry. 274:26448-26453
Nuclear factor kappaB (NF-kappaB) is an inducible transcription factor that regulates genes important in immunity and inflammation. The activity of NF-kappaB is highly regulated: transcriptionally active NF-kappaB proteins are sequestered in the cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9514579c02dac9c66a2080e7183a26ea
https://doi.org/10.1074/jbc.274.37.26448
https://doi.org/10.1074/jbc.274.37.26448
Publikováno v:
Inflammatory Bowel Diseases. 5:167-173
In animal models, the antiinflammatory mechanism of action of methotrexate has been attributed to elevation of the extracellular concentration of the endogenous autocoid, adenosine. Our goal was to determine if methotrexate elevates adenosine concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da684fe2ba0c6bfea8d65d939e481519
https://doi.org/10.1097/00054725-199908000-00004
https://doi.org/10.1097/00054725-199908000-00004