Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dennis C. Argentieri"'
Autor:
Todd C. Henninger, Dennis J. Hlasta, Michael P. Wachter, Dennis C. Argentieri, Michele A. Weidner-Wells, Michele Matheis, David M. Ritchie, Christine M. Boggs, Stephanie A. Fraga-Spano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4307-4311
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984bc281c15de937c9532b2050d824c4
https://doi.org/10.1016/j.bmcl.2004.05.080
https://doi.org/10.1016/j.bmcl.2004.05.080
Autor:
Jill M. Carton, Dennis C. Argentieri, Bruce P. Damiano, Michael R. D'Andrea, David J. Uhlinger
Publikováno v:
Thrombosis and Haemostasis. 86:1320-1326
SummaryThe response to vascular injury is a complex wound healing response involving cell proliferation, migration, remodeling and inflammation. In the present studies we employed a rat balloon angioplasty model of vascular injury to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5314b67e0932d8d036a38122f7e79a23
https://doi.org/10.1055/s-0037-1616067
https://doi.org/10.1055/s-0037-1616067
Autor:
Wei Wu, Michael P. Wachter, Dennis C. Argentieri, Elizabeth A. Malloy, Arminda G. Barbone, Michele Steber, Justin Ansell, David M. Ritchie, Thomas Kirchner, Monica Singer, Scott A. Beers
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:779-786
Compound 4k N-[5-(4-fluoro)phenoxythien-2-yl]methanesulfonamide is representative of a new class of potent inhibitors of 5-lipoxygenase (5-LO). These versatile compounds exhibit dose-dependent inhibition of 5-LO with IC50s ranging from 20–100 nM in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc9408694cd0050b5e57b1227e67d37
https://doi.org/10.1016/s0968-0896(97)00025-4
https://doi.org/10.1016/s0968-0896(97)00025-4
Autor:
Scott A. Waldman, Ian L. Smith, Thorir D. Bjornsson, John Misiti, Cheryl Vitow, Andrew T. Chow, Barbara Osborne, Francis A. Wong, Lisa Gillen, Dennis C. Argentieri
Publikováno v:
The Journal of Clinical Pharmacology. 36:462-468
This study was conducted to examine the pharmacokinetics and pharmacodynamics of tepoxalin in healthy volunteers, an antiinflammatory compound that inhibits cyclooxygenase and lipoxygenase. Tepoxalin was absorbed after oral administration of single d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c524ab1a53b75c1b8af770d04114c2
https://doi.org/10.1002/j.1552-4604.1996.tb05033.x
https://doi.org/10.1002/j.1552-4604.1996.tb05033.x
Autor:
Charlene D. Connelly, Ian L. Smith, Monica Singer, Dennis C. Argentieri, Robert B. Raffa, James J. Schupsky, Rebecca P. Martinez
Publikováno v:
Drug Development Research. 36:81-90
Tepoxalin is a novel dual inhibitor of cyclooxygenase (CO) and lipoxygenase (LO) pathways of arachidonic acid metabolism with a relative lack of gastrointestinal side effects within its preclinical therapeutic dose range. The present study investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de13e9735b289eb66373ca27e8340550
https://doi.org/10.1002/ddr.430360203
https://doi.org/10.1002/ddr.430360203
Autor:
Monica Singer, Michael Paul Ferro, Michele Steber, Dennis C. Argentieri, Michael P. Wachter, Kathy McCoy, William V. Murray, Dave M. Ritchie, Jihua Guan, Zhihua Sui
Publikováno v:
ChemInform. 31
Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution pattern of the pyrazole ring in 1 differentiates these compounds from most of the known selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d7793e802874d9a7f8749a9d2315b1
https://doi.org/10.1002/chin.200028121
https://doi.org/10.1002/chin.200028121
Autor:
Michael P. Wachter, Monica Singer, Dennis C. Argentieri, Eugene B. Grant, Deodialsingh Guiadeen, Dennis J. Hlasta
Publikováno v:
ChemInform. 33
The failure to fully regulate the inflammation response has been linked to diseases such as rheumatoid arthritis, septic shock syndrome, and asthma. The human complement system initiates and regulates the inflammation response through a cascade of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ceff8558994993060c6de39ca1a95a
https://doi.org/10.1002/chin.200209124
https://doi.org/10.1002/chin.200209124
Autor:
Xun Li, Bangping Xiang, Kristin M. Averill, Wai Ping Leung, Bohumila Fahmy, Paul F. Jackson, Dennis C. Argentieri, Hall Daniel A, John Siekierka, Xiaodong Fan, Thomas Razler, James L. Bullington, Gilbert C. Olini, Michael Reuman, Ping Ling, Demetrius Carter, Russell Wolff, Geoffrey R. Heintzelman, Druie Cavender, Scott A. Wadsworth, Kenneth C. Rupert, Ronald K. Russell, Yue Mei Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
Inhibition of the p38 map kinase pathway has been shown to be beneficial in the treatment of inflammatory diseases. The first class of potent p38 kinase inhibitors was the pyridinylimidazole compounds from SKB. Since then several pyridinylimidazole-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d98c9f8328eb28109b2118bac61f3c5
https://pubmed.ncbi.nlm.nih.gov/16971122
https://pubmed.ncbi.nlm.nih.gov/16971122
Autor:
Rathna Thyagarajan, John Siekierka, Robert Falotico, Demetrius Carter, Dennis C. Argentieri, Tom Jay Parry, Ruth Brosius
Publikováno v:
European journal of pharmacology. 524(1-3)
Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the effects of sirolimus and paclitaxel on cultured human coronary artery smooth muscle and endot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01f3e142d7e1f9fd011a24020992d2b
https://pubmed.ncbi.nlm.nih.gov/16271360
https://pubmed.ncbi.nlm.nih.gov/16271360
Autor:
Robert Falotico, Rathna Thyagarajan, John Siekierka, Dennis C. Argentieri, Tom Jay Parry, Ronald J. Tallarida
Publikováno v:
European journal of pharmacology. 532(1-2)
Although sirolimus is a potent inhibitor of vascular smooth muscle cell (VSMC) proliferation and is effective at preventing restenosis in the majority of clinical revascularization procedures employing sirolimus-eluting stents, some VSMC may escape t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75721302f88ba142427a281f6eef213
https://pubmed.ncbi.nlm.nih.gov/16448648
https://pubmed.ncbi.nlm.nih.gov/16448648