Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dennis C, Otero"'
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Marzia Scortegagna, Kathryn Hockemeyer, Igor Dolgalev, Joanna Poźniak, Florian Rambow, Yan Li, Yongmei Feng, Roberto Tinoco, Dennis C. Otero, Tongwu Zhang, Kevin Brown, Marcus Bosenberg, Linda M. Bradley, Jean-Christophe Marine, Ioannis Aifantis, Ze’ev A. Ronai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The ubiquitin ligase Siah2 has been implicated in immune responses. Here, the authors show that Siah2 null immune cells have an increased inflammatory response to inoculated melanoma cells, along with a reduced number of infiltrating immunosuppressiv
Externí odkaz:
https://doaj.org/article/b4571c9b4e094486a2056a1668569d65
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Effective adaptive immune responses are characterized by stages of development and maturation of T and B cell populations that respond to disturbances in the host homeostasis in cases of both infections and cancer. For the T cell compartment, this be
Externí odkaz:
https://doaj.org/article/69cfb3667b96436ab3b9bffae796676b
Autor:
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), 208(3), 603-617. American Association of Immunologists
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Monique L. Henriquez, Hyungseok Seo, Xue Lei, Eric S. Wang, Roberto Tinoco, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Summary/AbstractWe previously identified the adhesion molecule PSGL-1 as a T cell intrinsic immune checkpoint regulator of T cell exhaustion. Here we show that the ability of PSGL-1 to restrain TCR sginaling correlates with decreased expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb51d4fbb8372cd62d613e21bec9d52
https://doi.org/10.1101/2022.01.24.477602
https://doi.org/10.1101/2022.01.24.477602
Autor:
Jennifer L, Hope, Manzhi, Zhao, Christopher J, Stairiker, Caoimhe H, Kiernan, Alison J, Carey, Yvonne M, Mueller, Marjan, van Meurs, Inge, Brouwers-Haspels, Dennis C, Otero, Eun-Ah, Bae, Hannah A, Faso, Alex, Maas, Hans, de Looper, Paolo M, Fortina, Isidore, Rigoutsos, Linda M, Bradley, Stefan J, Erkeland, Peter D, Katsikis
Publikováno v:
J Immunol
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we characterized the expr
Autor:
Yan Li, Florian Rambow, Marzia Scortegagna, Ze'ev Ronai, Marcus Bosenberg, Igor Dolgalev, Roberto Tinoco, Ioannis Aifantis, Jean-Christophe Marine, Kevin M. Brown, Kathryn Hockemeyer, Yongmei Feng, Joanna Poźniak, Tongwu Zhang, Dennis C. Otero, Linda M. Bradley
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2−/− mice. Growth-inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985b8cf74350c45e409d0f9cbd1f35a4
https://lirias.kuleuven.be/handle/123456789/648722
https://lirias.kuleuven.be/handle/123456789/648722
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24972 (2011)
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susceptibility to infections or autoimmunity in both mice and humans. Here we report that mice lacking the IFNα/β-receptor (IFNAR1) or STAT1 display impa
Externí odkaz:
https://doaj.org/article/52e4fdf2fe7b45009da8b87885077194
Autor:
Eun-ah Bae, Jennifer L Hope, Dennis C Otero, Hannah A Faso, Ashley B Palete, Ze’ev A Ronai, Linda M Bradley
Publikováno v:
The Journal of Immunology. 206:14.12-14.12
Functional T cell exhaustion develops with persistent antigen exposure during chronic viral infection and cancer. Greater insights into T cell exhaustion are needed to promote immunity to viruses and tumors. RNF5 (RING-finger protein 5) is an E3 ubiq
Autor:
Hannah A. Faso, Eun-ah Bae, Christopher J. Stairiker, Garth Powis, Jennifer L. Hope, Dennis C. Otero, Linda M. Bradley, Ashley B. Palete, Petrus R. de Jong
Publikováno v:
Cancer Immunology Research. 9:PO014-PO014
We previously identified that the adhesion molecule P-selectin glycoprotein ligand-1 (PSGL-1) regulates T cell function and exhaustion in responses to chronic viral infection and melanoma tumors. Subsequently, our studies have focused on investigatin