Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Dennis C, Ko"'
Autor:
Taylor A. Stepien, Larissa A. Singletary, Fermin E. Guerra, Joyce E. Karlinsey, Stephen J. Libby, Sarah L. Jaslow, Margaret R. Gaggioli, Kyle D. Gibbs, Dennis C. Ko, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Ferric C. Fang
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTSalmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric fever S
Externí odkaz:
https://doaj.org/article/557b291ef5774526961df87681eb966d
Autor:
Minato Hirano, Gaddiel Galarza-Muñoz, Chloe Nagasawa, Geraldine Schott, Liuyang Wang, Alejandro L Antonia, Vaibhav Jain, Xiaoying Yu, Steven G Widen, Farren BS Briggs, Simon G Gregory, Dennis C Ko, William S Fagg, Shelton Bradrick, Mariano A Garcia-Blanco
Publikováno v:
eLife, Vol 12 (2023)
Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified, but their functions are incompletely understood. One of these genes codes for the RNA helicase DExD/H-Box Polypeptide 39B (DDX39B), which shows genetic an
Externí odkaz:
https://doaj.org/article/c38f1aa37a0a4f6ba7bae9127557c87f
Autor:
Liuyang Wang, Thomas J. Balmat, Alejandro L. Antonia, Florica J. Constantine, Ricardo Henao, Thomas W. Burke, Andy Ingham, Micah T. McClain, Ephraim L. Tsalik, Emily R. Ko, Geoffrey S. Ginsburg, Mark R. DeLong, Xiling Shen, Christopher W. Woods, Elizabeth R. Hauser, Dennis C. Ko
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background While genome-wide associations studies (GWAS) have successfully elucidated the genetic architecture of complex human traits and diseases, understanding mechanisms that lead from genetic variation to pathophysiology remains an impo
Externí odkaz:
https://doaj.org/article/39fc59f51cab48dda86b587f7fe9ca79
Autor:
Jeffrey S. Bourgeois, Caroline E. Anderson, Liuyang Wang, Jennifer L. Modliszewski, Wei Chen, Benjamin H. Schott, Nicolas Devos, Dennis C. Ko
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA methylome. Here, we leveraged single-molecule, real-time sequencing (SMRT-seq) to exam
Externí odkaz:
https://doaj.org/article/3090fc8d729b4249b16805cdabb74d4f
Autor:
Alyson B. Barnes, Rachel M. Keener, Benjamin H. Schott, Liuyang Wang, Raphael H. Valdivia, Dennis C. Ko
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100071- (2022)
Summary: Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with Chlamydia trachomatis (C. trachomatis), the wide range of genital and ocular disease manifestations are likely influ
Externí odkaz:
https://doaj.org/article/7f6bbf7c88c345af81126b7eeed8e51c
Variation in Leishmania chemokine suppression driven by diversification of the GP63 virulence factor
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
Leishmaniasis is a neglected tropical disease with diverse outcomes ranging from self-healing lesions, to progressive non-healing lesions, to metastatic spread and destruction of mucous membranes. Although resolution of cutaneous leishmaniasis is a c
Externí odkaz:
https://doaj.org/article/91e6e97eebdc443198d43569ca2e07bd
Autor:
Jeffrey S Bourgeois, Liuyang Wang, Agustin F Rabino, Jeffrey Everitt, Monica I Alvarez, Sahezeel Awadia, Erika S Wittchen, Rafael Garcia-Mata, Dennis C Ko
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009713 (2021)
Salmonella hijack host machinery in order to invade cells and establish infection. While considerable work has described the role of host proteins in invasion, much less is known regarding how natural variation in these invasion-associated host prote
Externí odkaz:
https://doaj.org/article/36b61b4de3bb4c32b3e73fb60442aa1a
Autor:
Hsin-I. Huang, Mark L. Jewell, Nourhan Youssef, Min-Nung Huang, Elizabeth R. Hauser, Brian E. Fee, Nathan P. Rudemiller, Jamie R. Privratsky, Junyi J. Zhang, Estefany Y. Reyes, Donghai Wang, Gregory A. Taylor, Michael D. Gunn, Dennis C. Ko, Donald N. Cook, Vidyalakshmi Chandramohan, Steven D. Crowley, Gianna Elena Hammer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Intestinal immunity is coordinated by specialized mononuclear phagocyte populations, constituted by a diversity of cell subsets. Although the cell subsets constituting the mononuclear phagocyte network are thought to be similar in both small and larg
Externí odkaz:
https://doaj.org/article/ec895c03dad444b39ecd52aa071d83d9
Publikováno v:
Annual Review of Genetics. 56:41-62
Since the identification of sickle cell trait as a heritable form of resistance to malaria, candidate gene studies, linkage analysis paired with sequencing, and genome-wide association (GWA) studies have revealed many examples of genetic resistance a
Autor:
Raquel Maeso-Díaz, Kuo Du, Christopher Pan, Cynthia D. Guy, Seh Hoon Oh, Tianyi Chen, Liuyang Wang, Dennis C. Ko, Linda Tang, Rajesh K. Dutta, Ji Hye Jun, Ayako Suzuki, Manal F. Abdelmalek, Xiao-Fan Wang, Anna Mae Diehl
Publikováno v:
Hepatology.