Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dennis Bromley"'
Autor:
Valerie Daggett, Dennis Bromley
Publikováno v:
Protein Sci
The p53 protein is a commonly studied cancer target because of its role in tumor suppression. Unfortunately, it is susceptible to mutation-associated loss of function; approximately 50% of cancers are associated with mutations to p53, the majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf2532e885a6285bf38479230ea7948
https://pubmed.ncbi.nlm.nih.gov/32715544
https://pubmed.ncbi.nlm.nih.gov/32715544
Publikováno v:
Protein Engineering Design and Selection. 29:377-390
The p53 tumor suppressor protein performs a critical role in stimulating apoptosis and cell cycle arrest in response to oncogenic stress. The function of p53 can be compromised by mutation, leading to increased risk of cancer; approximately 50% of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf19719edcefaf5993d4b83288deb99
https://doi.org/10.1093/protein/gzw035
https://doi.org/10.1093/protein/gzw035
Autor:
Dennis Bromley, Chris Brotherton, Rachel Bromnick, David Heathcote, Kevin Baker, Nigel Hunt, Sue Thomas, Douglas Howat, Vivian Vignoles, Sonja J. Ellis, David Scott, Peter Watson, Darren Walker, Sue Palmer, Roz Dixon, Rachel Gillibrand
Publikováno v:
Psychology Learning & Teaching. 2:142-163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b9ceed429dab14da7fd60dac5ebcf6
https://doi.org/10.2304/plat.2002.2.2.142
https://doi.org/10.2304/plat.2002.2.2.142
The need for data-centric scientific tools is growing; domains like biology, chemistry, and physics are increasingly adopting computational approaches. As a result, scientists must now deal with the challenges of big data. To address these challenges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c45736c6b835712cf182221e81e82bc
https://europepmc.org/articles/PMC4103159/
https://europepmc.org/articles/PMC4103159/
Autor:
Robert Su, Rudesh D. Toofanny, Steven J. Rysavy, Dennis Bromley, Tom Schmidlin, Valerie Daggett
Publikováno v:
Bioinformatics (Oxford, England). 30(4)
Summary: Modern scientific investigation is generating increasingly larger datasets, yet analyzing these data with current tools is challenging. DIVE is a software framework intended to facilitate big data analysis and reduce the time to scientific i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f788d22ffd159bbf0b90117327639b6b
https://pubmed.ncbi.nlm.nih.gov/24336804
https://pubmed.ncbi.nlm.nih.gov/24336804
Autor:
Dennis, Bromley, Valerie, Daggett
Publikováno v:
AMIA Summits on Translational Science Proceedings
Protein function is related to protein structure, and understanding disease-associated structural changes is critical both to understanding protein-mediated illness and to developing clinical therapies. We have developed a visual analytics tool calle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::976e56bdd44379d01cfb891c8a095ac3
https://pubmed.ncbi.nlm.nih.gov/24303293
https://pubmed.ncbi.nlm.nih.gov/24303293
The α-tocopherol transfer protein (α-TTP) is a liver protein that transfers α-tocopherol (vitamin E) to very-low-density lipoproteins (VLDLs). These VLDLs are then circulated throughout the body to maintain blood α-tocopherol levels. Mutations to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b92cf8e26a249c3a9cd77268e3777f
https://europepmc.org/articles/PMC3727652/
https://europepmc.org/articles/PMC3727652/
Autor:
Peter C. Anderson, Noah C. Benson, Dennis Bromley, Steven J. Rysavy, Marc W. van der Kamp, Alexander D. Scouras, Andrew M. Simms, Eric D. Merkley, R. Dustin Schaeffer, Valerie Daggett, David A. C. Beck, Rudesh D. Toofanny, Amanda L. Jonsson
Publikováno v:
Structure (London, England : 1993). 18(4)
The dynamic behavior of proteins is important for an understanding of their function and folding. We have performed molecular dynamics simulations of the native state and unfolding pathways of over 2000 protein/peptide systems (approximately 11,000 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70693fbeac5d814ee89a9a0e10b4ea20
https://pubmed.ncbi.nlm.nih.gov/20524218
https://pubmed.ncbi.nlm.nih.gov/20524218
Autor:
Justine Cassell, David R. DeMaso, Sarah Lualdi, Carol Strohecker, Edith Ackermann, Dennis Bromley, Beth Donegan, Judith Galler Karlin, Joseph Gonzalez-Heydrich, Marina Umaschi Bers
Publikováno v:
CHI
This paper describes exploration of uses of a computational storytelling environment on the Car- diology Unit of the ChildrenHospital in Boston, during the summer of 1997. Young cardiac patients ranging from age 7 to 16 used the SAGE environment to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14d2dc8bd0730e57e9d87672a5c99c9
https://doi.org/10.1145/274644.274725
https://doi.org/10.1145/274644.274725
Autor:
Dennis Bromley
Publikováno v:
Contemporary Psychology: A Journal of Reviews. 18:627-629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b08487af8ed1952e9b9ca0adbb33efb0
https://doi.org/10.1037/0011823
https://doi.org/10.1037/0011823