Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dennis B. Leveson-Gower"'
Autor:
Yuqiong Pan, Dennis B. Leveson-Gower, Patricia E. de Almeida, Antonio Pierini, Jeanette Baker, Mareike Florek, Hidekazu Nishikii, Byung-Su Kim, Rong Ke, Joseph C. Wu, Robert S. Negrin
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1793-1802 (2015)
Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as
Externí odkaz:
https://doaj.org/article/e334f832edb34799adb0da200b0b04dd
Autor:
Emanuela I Sega, Dennis B Leveson-Gower, Mareike Florek, Dominik Schneidawind, Richard H Luong, Robert S Negrin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86551 (2014)
Lag-3 has emerged as an important molecule in T cell biology. We investigated the role of Lag-3 in conventional T cell (Tcon) and regulatory T cell (Treg) function in murine GVHD with the hypothesis that Lag-3 engagement diminishes alloreactive T cel
Externí odkaz:
https://doaj.org/article/a0faece07ceb4400b242bf8d6059b24b
Autor:
Jeanette Baker, Antonio Pierini, Yuqiong Pan, Dennis B. Leveson-Gower, Robert S. Negrin, Mareike Florek, Hidekazu Nishikii, Patrícia de Almeida, Joseph C. Wu, Byung-Su Kim, Rong Ke
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1793-1802 (2015)
Summary Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as
Autor:
Robert S. Negrin, Amir M. Sadaghiani, Sang Min Lee, Ricardo E. Dolmetsch, Paul Novick, Angela N. Koehler, Chan Young Park, Dennis B. Leveson-Gower, Mi Ri Kim, Justin I. Odegaard, Olivia M. McPherson
Publikováno v:
Chemistry & Biology. 21:1278-1292
SummaryStore-operated calcium (SOC) channels are vital for activation of the immune cells, and mutations in the channel result in severe combined immunodeficiency in human patients. In lymphocytes, SOC entry is mediated by the Orai1 channel, which is
Autor:
Anna Wardowska, J. Michael Millis, Piotr Witkowski, Natalia Marek-Trzonkowska, Adam Krzystyniak, Ling-Jia Wang, Karolina Golab, Dennis B. Leveson-Gower, Xiaojun Wang, Piotr Trzonkowski
Publikováno v:
International Immunopharmacology. 16:364-370
T regulatory cells (Tregs) play a critical role in the immunologic tolerance to the graft in transplantation. Thus, due to their immunosuppressive capability, ex vivo expanded Tregs may be used as a cellular therapy and an attractive novel strategy t
Autor:
Piotr Witkowski, Piotr Trzonkowski, Dennis B. Leveson-Gower, Anna Wardowska, J. Michael Mills, Natalia Marek-Trzonkowska, Xiaojun Wang, Adam Krzystyniak, Karolina Golab, Jakub Grzanka
Publikováno v:
International Immunopharmacology. 16:343-347
Regulatory T cells (Treg) play pivotal role in the maintenance of immune homeostasis due to their suppressive abilities. It is important to understand the nature of Treg and the mechanisms by which they function. From recent studies, we can conclude
Autor:
Jeanette Baker, Richard Luong, Janelle A. Olson, Robert Zeiser, Dennis B. Leveson-Gower, Emanuela I. Sega, Robert S. Negrin
Publikováno v:
Blood. 117:3220-3229
CD4+ natural killer T (NKT) cells, along with CD4+CD25+ regulatory T cells (Tregs), are capable of controlling aberrant immune reactions. We explored the adoptive transfer of highly purified (> 95%) CD4+NKT cells in a murine model of allogeneic hemat
Autor:
Robert S. Negrin, Saar Gill, Jeanette Baker, Andreas Beilhack, Janelle A. Olson, Dennis B. Leveson-Gower
Publikováno v:
Blood. 115:4293-4301
Natural killer (NK) cells suppress graft-versus-host disease (GVHD) without causing GVHD themselves. Our previous studies demonstrated that allogeneic T cells and NK cells traffic similarly after allogeneic bone marrow transplantation (BMT). We there
Autor:
Andreas Beilhack, Dennis B. Leveson-Gower, Elizabeth A. Zambricki, Robert S. Negrin, Robert Zeiser, Neeraja Kambham
Publikováno v:
Biology of Blood and Marrow Transplantation. 13(12):1427-1438
Interleukin (IL)-18 stimulates T helper 1 (Th1) and Th2-mediated immune responses, and has been shown to modulate acute graft-versus-host disease (aGVHD). It is still unknown whether increased IL-18 levels during aGVHD are of host or donor origin, an
Autor:
Antonio Pierini, Dominik Schneidawind, Jeanette Baker, Yuqiong Pan, Dennis B. Leveson-Gower, Randall Armstrong, Everett Meyer, Robert S. Negrin, Mareike Florek
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145763 (2015)
PLoS ONE
PLoS ONE
The adoptive transfer of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in murine models of allogeneic hematopoietic cell transplantation (HCT) has been shown to protect recipient mice from lethal acute graft-versus-host disease (GVHD) and this approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31978473b1f57a2540ff6e2416c38985
http://hdl.handle.net/11391/1429467
http://hdl.handle.net/11391/1429467