Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dennis A. Simpson"'
Autor:
Wanjuan Feng, Dennis A. Simpson, Juan Carvajal-Garcia, Brandon A. Price, Rashmi J. Kumar, Lisle E. Mose, Richard D. Wood, Naim Rashid, Jeremy E. Purvis, Joel S. Parker, Dale A. Ramsden, Gaorav P. Gupta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.
Externí odkaz:
https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb
Autor:
Katerina D. Fagan-Solis, Dennis A. Simpson, Rashmi J. Kumar, Luciano G. Martelotto, Lisle E. Mose, Naim U. Rashid, Alice Y. Ho, Simon N. Powell, Y. Hannah Wen, Joel S. Parker, Jorge S. Reis-Filho, John H.J. Petrini, Gaorav P. Gupta
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1385-1399.e7 (2020)
Summary: The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genet
Externí odkaz:
https://doaj.org/article/c748e1c4c3444689abb982bb24303a91
Autor:
Jacquelyn J. Bower, Leah D. Vance, Matthew Psioda, Stephanie L. Smith-Roe, Dennis A. Simpson, Joseph G. Ibrahim, Katherine A. Hoadley, Charles M. Perou, William K. Kaufmann
Publikováno v:
npj Breast Cancer, Vol 3, Iss 1, Pp 1-12 (2017)
Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J. Bower and colleagues at the University of North C
Externí odkaz:
https://doaj.org/article/94f441a22a494a089060ea8ad3b50c9e
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
Supplementary Table S1 from Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f4819ae0809f91b0962b06ede00f0
https://doi.org/10.1158/1541-7786.22520628
https://doi.org/10.1158/1541-7786.22520628
Autor:
William K. Kaufmann, Richard S. Paules, Pierre R. Bushel, Feng Cao, Dennis A. Simpson, Yingchun Zhou, Jeff Chou, Tong Zhou
The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4133a81999fac3e35ea2411300c02e01
https://doi.org/10.1158/1541-7786.c.6542700.v1
https://doi.org/10.1158/1541-7786.c.6542700.v1
Autor:
Min-Guk Cho, Rashmi J. Kumar, Chien-Chu Lin, Joshua A. Boyer, Jamshaid A. Shahir, Katerina Fagan-Solis, Dennis A. Simpson, Cheng Fan, Christine E. Foster, Anna M. Goddard, Qinhong Wang, Ying Wang, Alice Y. Ho, Pengda Liu, Charles M. Perou, Qi Zhang, Robert K. McGinty, Jeremy E. Purvis, Gaorav P. Gupta
Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS/STING-mediated innate immune signaling and tumor suppression1-3. However, the mechanism for cGAS activation by endogenous DNA damage remains enigmatic, particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91194156b51e8c8ee91b4ac4eb3cf325
https://doi.org/10.1101/2022.12.09.519750
https://doi.org/10.1101/2022.12.09.519750
Publikováno v:
Seminars in radiation oncology. 32(1)
Many cancer therapies, including radiotherapy, induce DSBs as the major driving mechanism for inducing cancer cell death. Thus, modulating DSB repair has immense potential for radiosensitization, although such interventions must be carefully designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a68953b2d8c5b2dc86005b7545dc5e8
https://pubmed.ncbi.nlm.nih.gov/34861993
https://pubmed.ncbi.nlm.nih.gov/34861993
Autor:
Luciano G. Martelotto, M Kapustina, Jorge S. Reis-Filho, Gaorav P. Gupta, Dennis A. Simpson, John H.J. Petrini, Katerina D. Fagan-Solis
Publikováno v:
Cancer Research. 79:P1-06
Defects in the DNA damage repair system result in increased genomic instability and have recently been implicated as being drivers of tumorigenesis in both familial and sporadic breast cancers. To maintain genomic integrity, cells have a DNA damage r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec1b9a217ece4ee6e184c4c2ebd09dd
https://doi.org/10.1158/1538-7445.sabcs18-p1-06-08
https://doi.org/10.1158/1538-7445.sabcs18-p1-06-08
Autor:
Kuldeep Kumar, Ian L Matts, Andrei Klementov, Scott Sisco, Dennis A. Simpson, Edward R. Millero, Kareem Kaleem, Gina M. Terrago, Se Ryeon Lee
Publikováno v:
ECS Meeting Abstracts. :420-420
With increasing demand of high energy density lithium ion batteries, silicon (Si) based anodes are an obvious substitute of graphite based systems due to their high capacity. However, large volume changes of Si during lithiation and delithiation proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2198b4fafadea3b010f70e0919934b7
https://doi.org/10.1149/ma2022-012420mtgabs
https://doi.org/10.1149/ma2022-012420mtgabs
Autor:
Wanjuan Feng, Jang-Eun Cho, Nate Hathaway, Chelsea M. Smith, Juan Carvajal-Garcia, Dennis A. Simpson, Dale A. Ramsden, Kathryn M. Headley, Gaorav P. Gupta
Publikováno v:
Nucleic Acids Research
Genome integrity and genome engineering require efficient repair of DNA double-strand breaks (DSBs) by non-homologous end joining (NHEJ), homologous recombination (HR), or alternative end-joining pathways. Here we describe two complementary methods f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676e480a4c0772af2eb4d96aa8906c2c
https://pubmed.ncbi.nlm.nih.gov/33963863
https://pubmed.ncbi.nlm.nih.gov/33963863