Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Dennis A. Lowther"'
Autor:
Absorn Sriratana, Elizabeth E. Gardiner, Barry Veitch, H. Clem Robinson, Su San Mok, Dennis A. Lowther, Christopher J. Handley
Publikováno v:
European Journal of Biochemistry. 221:871-879
Rabbit peritoneal polymorphonuclear neutrophils (PMN), incubated in medium containing [35S]sulphate, incorporated 35S into proteoglycan and protein fractions. Approximately 46% of the 35S-labelled macromolecules associated with the PMN cells after 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d65d24ce728fab16fcd03ba075db85b
https://doi.org/10.1111/j.1432-1033.1994.tb18802.x
https://doi.org/10.1111/j.1432-1033.1994.tb18802.x
Autor:
Dennis A. Lowther, Absorn Sriratana, Elizabeth E. Gardiner, H C Robinson, Christopher J. Handley, S S Mok
Publikováno v:
Europe PubMed Central
The incorporation of [35S]sulphate into macromolecules by rabbit peritoneal polymorphonuclear neutrophils (PMN) in vitro revealed that two major groups of 35S-labelled macromolecules were synthesized by these cells. The first group did not bind to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfe1d2338a6955eab2bece46540cd1a
https://doi.org/10.1042/bj2880577
https://doi.org/10.1042/bj2880577
Publikováno v:
Agents and Actions. 32:299-304
Articular cartilage proteoglycan biosynthesis was substantially inhibited by the competitive glycolytic inhibitor 2-deoxyglucose (approximately 65% at 100 mM), but to a much lesser degree (approximately 10%) by the oxidative phosphorylation uncoupler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a579ffea8790bdec5d274119798a536e
https://doi.org/10.1007/bf01980890
https://doi.org/10.1007/bf01980890
Publikováno v:
Free radical biologymedicine. 10(2)
The myeloperoxidase-derived oxidant, hypochlorite (OCl-) was shown to be able to degrade proteoglycan aggregate prepared from bovine articular cartilage. Exposure of proteoglycan aggregate to OCl- concentrations less than 10(-4) M resulted in a decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea34739cc57d19bdb216cf1ec15b879
https://pubmed.ncbi.nlm.nih.gov/1849864
https://pubmed.ncbi.nlm.nih.gov/1849864
Publikováno v:
Free Radical Biology and Medicine. 9:141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c25993d5cf71071c6a8b3abd523c37
https://doi.org/10.1016/0891-5849(90)90675-9
https://doi.org/10.1016/0891-5849(90)90675-9
Autor:
Dennis A. Lowther, S. Handley
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 500:132-139
Proteoglycan biosynthesis by cultured chondrocytes was shown to be depressed by extracellular concentrations of proteoglycan and partially degraded proteoglycan. This reduction in proteoglycan synthesis was reversible on removal of the added proteogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d233fad9b222e6f12051fc9f6abe48a
https://doi.org/10.1016/0304-4165(77)90053-8
https://doi.org/10.1016/0304-4165(77)90053-8
Autor:
Margaret A. Campbell, Christopher J. Handley, Dennis A. Lowther, Vincent C. Hascall, Robert A. Campbell
Publikováno v:
Archives of Biochemistry and Biophysics. 234:275-289
Proteoglycans in cultures of adult bovine articular cartilage labeled with [35S]sulfate after 5 days in culture and maintained in medium containing 20% fetal calf X serum had longer half-lives (average 11 days) compared with those of the same tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee996b875a906af0a0f585c7db0ed623
https://doi.org/10.1016/0003-9861(84)90350-3
https://doi.org/10.1016/0003-9861(84)90350-3
Autor:
Dennis A. Lowther, L Drummond, S. Graves, S Faine, Richard A. Strugnell, Christopher J. Handley
Publikováno v:
Sexually Transmitted Infections. 60:75-82
We investigated by means of radiolabelled precursors the source and nature of the polyanionic macromolecules present in rabbit tissues during active syphilis infection. Previous studies indicated that Treponema pallidum itself does not synthesise gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9206dc0c71324f1ad661a78b4de75db
https://doi.org/10.1136/sti.60.2.75
https://doi.org/10.1136/sti.60.2.75
Autor:
Dennis A. Lowther, P M Royce
Publikováno v:
Connective Tissue Research. 6:215-221
A fluorimetric procedure for the determination of the DNA content of cartilage is described. The tissue is initially solubilised by digestion with papain, and ethidium bromide is used for the subsequent quantitation of DNA. The basis of the procedure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c57b46b9efd81b3635794fd4df3806
https://doi.org/10.3109/03008207909152323
https://doi.org/10.3109/03008207909152323
Publikováno v:
Cell Biology International Reports. 9:753-782
The major proteoglycan of articular cartilage is a protein-polysaccharide of great complexity. The structure of this macromolecule is described in this article and is correlated to the function of proteoglycans within the extracellular matrix of cart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ec1b1bf13eec2431d210b1466f05e2
https://doi.org/10.1016/0309-1651(85)90095-5
https://doi.org/10.1016/0309-1651(85)90095-5