Zobrazeno 1 - 10 of 300 pro vyhledávání: '"Dennis A Dougherty"'
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Akademický článek
Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands
Autor: Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v: eLife, Vol 11 (2022)
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz: https://doaj.org/article/4b4e86491b454335b0724b76381431a8
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3
Akademický článek
Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface Expression.
Autor: Weston A Nichols, Brandon J Henderson, Christopher B Marotta, Caroline Y Yu, Chris Richards, Dennis A Dougherty, Henry A Lester, Bruce N Cohen
Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0158032 (2016)
A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes wi
Externí odkaz: https://doaj.org/article/f0f4f3c60e354e3f99af307bbfe38ec4
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6
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids
Autor: Nandan Haloi, Shan Huang, Aaron N. Nichols, Eve J. Fine, Christopher B. Marotta, Dennis A. Dougherty, Erik Lindahl, Rebecca J. Howard, Stephen L. Mayo, Henry A. Lester
Publikováno v: bioRxiv
To develop more sensitive fluorescent protein sensors for nicotine, we combined computational protein design, site-saturated, site-directed, and combinatorial mutagenesis with fluorescence assays, molecular dynamics simulations, and absorbance measur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e006d2d998b11ecd045bc5d0daafcc24
https://doi.org/10.1101/2023.01.16.524298
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Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Autor: Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, Charlene H. Kim, Stephen N. Grant, David P. Walton, Bruce N. Cohen, Rebekkah Hammar, Loren L. Looger, Per Artursson, Dennis A. Dougherty, Henry A. Lester
Publikováno v: Journal of Neuroscience
bioRxiv
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin transporter (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b270db0c9b8f16cd7ed2f4edcd6f0794
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8
Expression of Mutant Glycine Receptors in
Autor: Sarah C R, Lummis, Dennis A, Dougherty
Publikováno v: Membranes. 12(10)
Pentameric ligand-gated ion channels (pLGIC) play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular domain (ECD), a transmembrane domain (TMD) and an intracellular doma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df9fd7e28ec750a58b45246ee764ac9e
https://pubmed.ncbi.nlm.nih.gov/36295771
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9
Characterization of Binding Site Interactions and Selectivity Principles in the α3β4 Nicotinic Acetylcholine Receptor
Autor: Hailey J. Knox, Hugo Rego Campello, Henry A. Lester, Timothy Gallagher, Dennis A. Dougherty
Publikováno v: Journal of the American Chemical Society. 144(35)
Nicotinic acetylcholine receptors (nAChRs) play an important role in neurotransmission and are also involved in addiction and several disease states. There is significant interest in therapeutic targeting of nAChRs; however, achieving selectivity for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2093e3427e6a8fcb92fbecf1c279c3
https://pubmed.ncbi.nlm.nih.gov/36006801
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