Výsledky vyhledávání - "Dennis A Carson"

Akademický článek

Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes.

Autor: Tomoko Hayashi, Shiyin Yao, Brian Crain, Victor J Promessi, Luke Shyu, Caroline Sheng, McNancy Kang, Howard B Cottam, Dennis A Carson, Maripat Corr

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129867 (2015)

Autoimmune diabetes mellitus (DM) results from the destruction of pancreatic islet cells by activated T lymphocytes, which have been primed by activated dendritic cells (DC). Individualized therapy with ex vivo DC manipulation and reinfusion has been

Externí odkaz: https://doaj.org/article/a0deb4f5bc424838a90918bde039bbae

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Akademický článek

Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.

Autor: Christian L Barrett, Richard B Schwab, HyunChul Jung, Brian Crain, Daniel J Goff, Catriona H M Jamieson, Patricia A Thistlethwaite, Olivier Harismendy, Dennis A Carson, Kelly A Frazer

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58714 (2013)

The only therapeutic options that exist for squamous cell lung carcinoma (SCC) are standard radiation and cytotoxic chemotherapy. Cancer stem cells (CSCs) are hypothesized to account for therapeutic resistance, suggesting that CSCs must be specifical

Externí odkaz: https://doaj.org/article/626ebf7a0297497281c3dfce62155e27

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Akademický článek

Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

Autor: Tomoko Hayashi, Shiyin Yao, Brian Crain, Michael Chan, Rommel I Tawatao, Christine Gray, Linda Vuong, Fitzgerald Lao, Howard B Cottam, Dennis A Carson, Maripat Corr

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45860 (2012)

The Toll-like receptors (TLR) have been advocated as attractive therapeutic targets because TLR signaling plays dual roles in initiating adaptive immune responses and perpetuating inflammation. Paradoxically, repeated stimulation of bone marrow monon

Externí odkaz: https://doaj.org/article/16ff2ba27a834476b5bee9d24d27d199

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Akademický článek

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39725 (2012)

Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonl

Externí odkaz: https://doaj.org/article/6a6e685aeb1a4e9ea677136b58ec1e0c

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Akademický článek

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

Autor: Desheng Lu, Jerry X Liu, Tomoyuki Endo, Haowen Zhou, Shiyin Yao, Karl Willert, Ingo G H Schmidt-Wolf, Thomas J Kipps, Dennis A Carson

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8294 (2009)

BACKGROUND:Aberrant activation of Wnt/beta-catenin signaling promotes the development of several cancers. It has been demonstrated that the Wnt signaling pathway is activated in chronic lymphocytic leukemia (CLL) cells, and that uncontrolled Wnt/beta

Externí odkaz: https://doaj.org/article/209b7c9f1e9a401ebf47daad7ff7a248

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Akademický článek

A novel approach for determining cancer genomic breakpoints in the presence of normal DNA.

Autor: Yu-Tsueng Liu, Dennis A Carson

Publikováno v: PLoS ONE, Vol 2, Iss 4, p e380 (2007)

CDKN2A (encodes p16(INK4A) and p14(ARF)) deletion, which results in both Rb and p53 inactivation, is the most common chromosomal anomaly in human cancers. To precisely map the deletion breakpoints is important to understanding the molecular mechanism

Externí odkaz: https://doaj.org/article/1ba77000ef8a45408bbb3f10f2eeb8c2

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