Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study

Autor: James A Platts-Mills, MD, Jie Liu, PhD, Elizabeth T Rogawski, PhD, Furqan Kabir, MSc, Paphavee Lertsethtakarn, PhD, Mery Siguas, BSc, Shaila S Khan, MSc, Ira Praharaj, MD, Arinao Murei, BSc, Rosemary Nshama, BSc, Buliga Mujaga, BSc, Alexandre Havt, PhD, Irene A Maciel, PhD, Timothy L McMurry, PhD, Darwin J Operario, PhD, Mami Taniuchi, PhD, Jean Gratz, MS, Suzanne E Stroup, MS, James H Roberts, Adil Kalam, MSc, Fatima Aziz, MSc, Shahida Qureshi, MSc, M Ohedul Islam, MSc, Pimmada Sakpaisal, MSc, Sasikorn Silapong, B BSc, Pablo P Yori, MPH, Revathi Rajendiran, MSc, Blossom Benny, MSc, Monica McGrath, ScD, Benjamin J J McCormick, DPhil, Jessica C Seidman, PhD, Dennis Lang, PhD, Michael Gottlieb, PhD, Richard L Guerrant, MD, Aldo A M Lima, ProfPhD, Jose Paulo Leite, PhD, Amidou Samie, PhD, Pascal O Bessong, ProfPhD, Nicola Page, PhD, Ladaporn Bodhidatta, MD, Carl Mason, MD, Sanjaya Shrestha, MD, Ireen Kiwelu, PhD, Estomih R Mduma, MPH, Najeeha T Iqbal, PhD, Zulfiqar A Bhutta, ProfPhD, Tahmeed Ahmed, ProfMBBS, Rashidul Haque, PhD, Gagandeep Kang, ProfMD, Margaret N Kosek, MD, Eric R Houpt, ProfMD, Angel Mendez Acosta, Rosa Rios de Burga, Cesar Banda Chavez, Julian Torres Flores, Maribel Paredes Olotegui, Silvia Rengifo Pinedo, Dixner Rengifo Trigoso, Angel Orbe Vasquez, Imran Ahmed, Didar Alam, Asad Ali, Muneera Rasheed, Sajid Soofi, Ali Turab, Aisha Yousafzai, Anita KM Zaidi, Binob Shrestha, Bishnu Bahadur Rayamajhi, Tor Strand, Geetha Ammu, Sudhir Babji, Anuradha Bose, Ajila T George, Dinesh Hariraju, M. Steffi Jennifer, Sushil John, Shiny Kaki, Priyadarshani Karunakaran, Beena Koshy, Robin P Lazarus, Jayaprakash Muliyil, Preethi Ragasudha, Mohan Venkata Raghava, Sophy Raju, Anup Ramachandran, Rakhi Ramadas, Karthikeyan Ramanujam, Anuradha Rose, Reeba Roshan, Srujan L Sharma, Shanmuga Sundaram, Rahul J Thomas, William K Pan, Ramya Ambikapathi, J Daniel Carreon, Viyada Doan, Christel Hoest, Stacey Knobler, Mark A Miller, Stephanie Psaki, Zeba Rasmussen, Stephanie A Richard, Karen H Tountas, Erling Svensen, Caroline Amour, Eliwaza Bayyo, Regisiana Mvungi, John Pascal, Ladislaus Yarrot, Leah Barrett, Rebecca Dillingham, William A Petri, Rebecca Scharf, AM Shamsir Ahmed, Md Ashraful Alam, Umma Haque, Md Iqbal Hossain, Munirul Islam, Mustafa Mahfuz, Dinesh Mondal, Baitun Nahar, Fahmida Tofail, Ram Krishna Chandyo, Prakash Sunder Shrestha, Rita Shrestha, Manjeswori Ulak, Aubrey Bauck, Robert Black, Laura Caulfield, William Checkley, Gwenyth Lee, Kerry Schulze, Samuel Scott, Laura E Murray-Kolb, A Catharine Ross, Barbara Schaefer, Suzanne Simons, Laura Pendergast, Cláudia B Abreu, Hilda Costa, Alessandra Di Moura, José Quirino Filho, Álvaro M Leite, Noélia L Lima, Ila F Lima, Bruna LL Maciel, Pedro HQS Medeiros, Milena Moraes, Francisco S Mota, Reinaldo B Oriá, Josiane Quetz, Alberto M Soares, Rosa MS Mota, Crystal L Patil, Cloupas Mahopo, Angelina Maphula, Emanuel Nyathi

Publikováno v: The Lancet Global Health, Vol 6, Iss 12, Pp e1309-e1318 (2018)

Summary: Background: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refi

Externí odkaz: https://doaj.org/article/8ba54b6c559f48a19a10f99f677a66a7

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

Autor: James A Platts-Mills, MD, Sudhir Babji, MD, Ladaporn Bodhidatta, MD, Jean Gratz, BSc, Rashidul Haque, MD, Alexandre Havt, PhD, Benjamin JJ McCormick, DPhil, Monica McGrath, ScD, Maribel Paredes Olortegui, BSc, Amidou Samie, PhD, Sadia Shakoor, MBBS, Dinesh Mondal, MD, Ila FN Lima, PhD, Dinesh Hariraju, MSc, Bishnu B Rayamajhi, BSc, Shahida Qureshi, MSc, Furqan Kabir, MSc, Pablo P Yori, MPH, Brenda Mufamadi, BTech, Caroline Amour, MSc, J Daniel Carreon, MS, Stephanie A Richard, PhD, Dennis Lang, PhD, Pascal Bessong, PhD, Esto Mduma, MPH, Tahmeed Ahmed, MBBS, Aldo AAM Lima, MD, Carl J Mason, MD, Anita KM Zaidi, MBBS, Zulfiqar A Bhutta, PhD, Margaret Kosek, MD, Richard L Guerrant, MD, Michael Gottlieb, PhD, Mark Miller, MD, Gagandeep Kang, MD, Dr. Eric R Houpt, MD

Publikováno v: The Lancet Global Health, Vol 3, Iss 9, Pp e564-e575 (2015)

Background: Most studies of the causes of diarrhoea in low-income and middle-income countries have looked at severe disease in people presenting for care, and there are few estimates of pathogen-specific diarrhoea burdens in the community. Methods: W

Externí odkaz: https://doaj.org/article/b801ab6d85144335b6f6de1bbd3a2bda

Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: results from the MAL-ED study

Autor: Erling Svensen, Gagandeep Kang, Dixner Rengifo Trigoso, M Munirul Islam, Benjamin J.J. McCormick, Ramya Ambikapathi, Sophy Raju, Rita Shrestha, Cláudia B. Abreu, Ram Krishna Chandyo, Maribel Paredes Olotegui, Gaurvika M. L. Nayyar, Archana Mohale, Margaret Kosek, Rebecca Blank, Álvaro M. Leite, Srujan Lam Sharma, Manjeswori Ulak, Richard L. Guerrant, Anup Ramachandran, Robin P. Lazarus, Josiane da Silva Quetz, AM Shamsir Ahmed, Estomih R. Mduma, Binob Shrestha, Anita K. M. Zaidi, Aubrey Bauck, Cesar Banda Chavez, Regisiana Mvungi, Silvia Rengifo Pinedo, Sanjaya K. Shrestha, Jean Gratz, Sudhir Babji, Priyadarshani Karunakaran, Pablo Peñataro Yori, José Q. Filho, Laura E. Murray-Kolb, Rosa Maria Salani Mota, Stephanie A. Richard, Ajila T. George, Sajid Bashir Soofi, Vivek Charu, Rosemary Nshama, Zeba A Rasmussen, M. Steffi Jennifer, Rahul J. Thomas, Ladislaus Blacy Yarrot, Alberto M. Soares, Noélia L. Lima, Laura L. Pendergast, Milena Lima de Moraes, Ila F. N. Lima, A. Catharine Ross, Eric R. Houpt, Ladaporn Bodhidatta, Laura E. Caulfield, Estomih Mduma, Tahmeed Ahmed, Jayaprakash Muliyil, Mery Siguas Salas, Rebecca Dillingham, Shahida Qureshi, Sushil John, Caroline Amour, Francisco Suetônio Bastos Mota, Pedro H. Q. S. Medeiros, Angel Mendez Acosta, Iqbal Hossain, Eliwaza Bayyo, Dinesh Mondal, Imran Ahmed, Buliga Mujaga Swema, H. Costa, Michael Gottlieb, Beena Koshy, Mark A. Miller, Vivian Ota Wang, Jhanelle Graham, Muneera A. Rasheed, Alexandre Havt, Bruna Leal Lima Maciel, Cloupas Mahopo, Anuradha Bose, Prakash S. Shrestha, Jessica C. Seidman, Monica McGrath, Alessandra Di Moura, Ali Turab, Viyada Doan, William Pan, Pascal O. Bessong, Didar Alam, Rakhi Ramadas, Tor A. Strand, Reinaldo B. Oriá, Stephanie Psaki, Karthikeyan Ramanujam, John M. Pascal, Rosa Burga, Amidou Samie, William A. Petri, Dinesh Hariraju, Dennis Lang, Christel Hoest, Robert E. Black, Karen H. Tountas, Mohan Venkata Raghava, Angel Orbe Vasquez, Zulfiqar A Bhutta, Emanuel Nyathi, Julian Torres Flores, Rashidul Haque, Leah J. Barrett, J. Daniel Carreon, Carl J. Mason, Zulfiqar A. Bhutta, Stacey Knobler, Rebecca J. Scharf, Suzanne Simons, Kerry Schulze, Crystal L. Patil, Aldo A. M. Lima, Reeba Roshan, Angelina Maphula, Maribel Paredes Olortegui, James A Platts-Mills, Fahmida Tofail, Shiny Kaki, Asad Ali, Gwenyth O. Lee, Sanjaya K. Shrestra, Mustafa Mahfuz, Shanmuga Sundaram, William Checkley, Barbara A. Schaefer

Publikováno v: The American Journal of Clinical Nutrition

Background Environmental enteric dysfunction (EED) is thought to increase the risk of micronutrient deficiencies, but few studies adjust for dietary intakes and systemic inflammation. Objective We tested whether EED is associated with micronutrient d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0938431c2ba058b258d7abe8b5c0e903
https://doi.org/10.1093/ajcn/nqz151

Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study

Autor: Estomih Mdumah, Shahida Qureshi, Anita K. M. Zaidi, Dennis Lang, Pablo Peñataro Yori, Margaret Kosek, Sanjaya K. Shrestha, Jean Gratz, Erling Svensen, Tahmeed Ahmed, Caroline Amour, Michael Gottlieb, Pascal O. Bessong, James A Platts-Mills, Eric R. Houpt, Ladaporn Bodhidatta, Ramanujam Karthikeyan, Aldo A. M. Lima, Richard L. Guerrant, Jessica C. Seidman, Jasmin Shrestha, Gagandeep Kang, Amidou Samie, Rashidul Haque, Sudhir Babji, Venkata Raghava Mohan, Monica McGrath, Emanuel Nyathi

Publikováno v: The Journal of Infectious Diseases. 216:305-316

Background In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Methods Children were recruited by 17 days of age and followed to 24 months with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b06deac50bfb6b2168ce765affbbc7f
https://doi.org/10.1093/infdis/jix199

Enteroaggregative Escherichia coli Subclinical Infection and Coinfections and Impaired Child Growth in the MAL-ED Cohort Study

Autor: Pablo Peñataro Yori, Estomih Mduma, Dennis Lang, Cláudia B. Abreu, Carl J. Mason, Francisco S Junior, Noélia L. Lima, Monica McGrath, Christopher Troeger, Herlice N. Veras, Aldo A. M. Lima, Erling Svensen, William K-Y Pan, Tahmeed Ahmed, Pascal O. Bessong, Eric R. Houpt, José Q. Filho, Alberto M. Soares, Alexandre Havt, Ila F. N. Lima, Ben J J McCormick, Shahida Qureshi, Gangadeep Kang, Michael Gottlieb, Elizabeth T. Rogawski, Jean Gratz, Sudhir Babji, Ladaporn Bodhidatta, Amidou Samie, Rosa Maria Salani Mota, Mara A Prata, Rashidul Haque, Margaret Kosek, Richard L. Guerrant, Sadia Shakoor, Shrestha Jasmin, Zulfigar A. Bhutta, James A Platts-Mills, Pedro H. Q. S. Medeiros

Publikováno v: Journal of pediatric gastroenterology and nutrition. 66(2)

We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first 6 months of life on child growth.Nondiarrheal samples from 1684 children across 8 Multisite Birth Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905ba0c85da1d042efbfac64de7f9489
https://pubmed.ncbi.nlm.nih.gov/29356769