Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Dennis, Kätzel"'
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Hyperactivity of the human anterior hippocampus has been reported to spread from its CA1 subfield to the subiculum around the onset of first-episode psychosis and could be a cellular target for early therapeutic intervention in the schizophr
Externí odkaz:
https://doaj.org/article/5b374a3fdc324dceb52418001eaa4730
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundNeuropsychopharmacological compounds may exert complex brain-wide effects due to an anatomically and genetically broad expression of their molecular targets and indirect effects via interconnected brain circuits. Electrophysiological measur
Externí odkaz:
https://doaj.org/article/983ab2f6813a452ab167107644fd0bc7
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3dfcb316639d4912b956b0ef23b4b427
Autor:
Martin M. Jendryka, Uwe Lewin, Bastiaan van der Veen, Sampath K. T. Kapanaiah, Vivien Prex, Daniel Strahnen, Thomas Akam, Birgit Liss, Anton Pekcec, Wiebke Nissen, Dennis Kätzel
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsi
Externí odkaz:
https://doaj.org/article/e03ece03855f4b4da4d865aaec55d90b
Autor:
Sampath K.T. Kapanaiah, Dennis Kätzel
Publikováno v:
HardwareX, Vol 14, Iss , Pp e00429- (2023)
In vivo electro- and optophysiology experiments in rodents reveal the neural mechanisms underlying behavior and brain disorders but mostly involve a cable connection between an implant in the animal and an external recording device. Standard tethers
Externí odkaz:
https://doaj.org/article/51b86f61cc0548fa91215857f6936325
Autor:
Kasyoka Kilonzo, Daniel Strahnen, Vivien Prex, John Gems, Bastiaan van der Veen, Sampath K. T. Kapanaiah, Bhargavi K. B. Murthy, Stefanie Schulz, Rolf Sprengel, David Bannerman, Dennis Kätzel
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Schizophrenia is associated with a broad range of severe and currently pharmacoresistant cognitive deficits. Prior evidence suggests that hypofunction of AMPA-type glutamate receptors (AMPARs) containing the subunit GLUA1, encoded by GRIA1,
Externí odkaz:
https://doaj.org/article/5b41206531d5432aa8c18a49690a5e52
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Operant boxes enable the application of complex behavioural paradigms to support circuit neuroscience and drug discovery research. However, commercial operant box systems are expensive and often not optimised for combining behaviour with neu
Externí odkaz:
https://doaj.org/article/2f278635aa3c4b078d5b11e1833036ac
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Schizophrenia is a severe psychiatric disorder whose neurodevelopmental pathogenesis includes a prodromal phase before its diagnostically decisive—namely psychotic—symptoms are present. This prodrome is characterized by cognitive and affective de
Externí odkaz:
https://doaj.org/article/d392127a5e464c009afdf9e26dbee131
Autor:
Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis.
Externí odkaz:
https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da068
Autor:
Kasyoka Kilonzo, Bastiaan van der Veen, Jasper Teutsch, Stefanie Schulz, Sampath K. T. Kapanaiah, Birgit Liss, Dennis Kätzel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract A hypofunction of N-methyl-D-aspartate glutamate receptors (NMDARs) has been implicated in the pathogenesis of schizophrenia by clinical and rodent studies. However, to what extent NMDAR-hypofunction in distinct cell-types across the brain c
Externí odkaz:
https://doaj.org/article/34948e7f5a9c4290958085c57becf0fc