Nicotinamide pharmacokinetics in humans and mice: A comparative assessment and the implications for radiotherapy

Autor: Horsman, Michael Robert, Høyer, Morten, Honess, D J, Dennis, I F, Overgaard, Jens

Publikováno v: Horsman, M R, Høyer, M, Honess, D J, Dennis, I F & Overgaard, J 1993, ' Nicotinamide pharmacokinetics in humans and mice: A comparative assessment and the implications for radiotherapy ', Radiotherapy & Oncology, vol. 27, no. 2, pp. 131-139 .

Healthy human volunteers orally ingested escalating doses of up to 6 g nicotinamide in capsule form on an empty stomach. Some side-effects were seen although these were mild and transient. HPLC analysis of blood samples showed peak plasma levels, typ

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Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.

Autor: Laurence, VM, Ward, R, Dennis, IF, Bleehen, NM, Laurence, V M, Dennis, I F, Bleehen, N M

Publikováno v: British Journal of Cancer; Jul1995, Vol. 72 Issue 1, p198-205, 8p

Pharmacokinetics of BW12C and mitomycin C, given in combination in a phase 1 study in patients with advanced gastrointestinal cancer.

Autor: Dennis, Ian, Ramsay, Jonathan, Workman, Paul, Bleehen, Norman, Dennis, I F, Ramsay, J R, Workman, P, Bleehen, N M

Publikováno v: Cancer Chemotherapy & Pharmacology; Jan1993, Vol. 32 Issue 1, p67-72, 6p

Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice

Autor: Honess, D. J., Dennis, I. F., Bleehen, N. M.

Publikováno v: Radiotherapy and Oncology; 1993, Vol. 28 Issue: 3 p208-208, 1p

Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.

Autor: Carpenter KL; Department of Pathology, University of Cambridge, UK. klhc@mole.bio.cam.ac.uk, Dennis IF, Challis IR, Osborn DP, Macphee CH, Leake DS, Arends MJ, Mitchinson MJ

Publikováno v: FEBS letters [FEBS Lett] 2001 Sep 21; Vol. 505 (3), pp. 357-63.