Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

Autor: Madeleine Bossaert, Angélique Pipier, Jean-Francois Riou, Céline Noirot, Linh-Trang Nguyên, Remy-Felix Serre, Olivier Bouchez, Eric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gomez

Publikováno v: eLife, Vol 10 (2021)

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA doubl

Externí odkaz: https://doaj.org/article/8eef65b6820b4fcd9287f486337c2989

supplementary Figure S4 from The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks

Autor: Patrick Calsou, Nicolas Guilbaud, Bruno Gomes, Carine Racca, Philippe Frit, Dennis Gomez, Florence Larminat, Oriane Bombarde

Figure S4 shows the calibration of the initial level of TOP2αcc after cell treatment with etoposide or F14512.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014008e5c625cae9dbcd3afc50deb92e
https://doi.org/10.1158/1535-7163.22508979.v1

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

Autor: Eric Defrancq, Annie Adrait, Alexandre Devaux, Yohann Couté, Sébastien Britton, Thomas Lavergne, Dennis Gomez, Angélique Pipier, Jean-François Riou, Patrick Calsou

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-92806-8⟩
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-92806-8⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

G-quadruplexes (G4) are non-canonical secondary structures consisting in stacked tetrads of hydrogen-bonded guanines bases. An essential feature of G4 is their intrinsic polymorphic nature, which is characterized by the equilibrium between several co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea7d762a90d56ace5e8095cfccb74de
https://hal.archives-ouvertes.fr/hal-03369749/file/41598_2021_Article_92806.pdf

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

Autor: Olivier Bouchez, Patrick Calsou, Madeleine Bossaert, Linh-Trang Nguyên, Sébastien Britton, Jean-François Riou, Dennis Gomez, Angélique Pipier, Céline Noirot, Eric Defrancq, Remy-Felix Serre

Publikováno v: eLife
eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.65184⟩
eLife, Vol 10 (2021)

International audience; G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c415173e60a18ef0d4106f45dd781a
http://europepmc.org/articles/PMC8279764

G-quadruplexes unfolding by RHAU helicase

Autor: Jean-Louis Mergny, Anne Bourdoncle, Dennis Gomez, Nassima Meriem Gueddouda, Oscar Mendoza

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:1382-1388

G-quadruplexes (G4) are RNA and DNA secondary structures formed by the stacking of guanine quartets in guanine rich sequences. Quadruplex-prone motifs may be found in key genomic regions such as telomeres, ribosomal DNA, transcriptional activators an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d82fb2a849443740f6885ffc79db68f
https://doi.org/10.1016/j.bbagen.2017.01.006