Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death

Autor: Na, Rong, Zheng, S. Lilly, Han, Misop, Yu, Hongjie, Jiang, Deke, Shah, Sameep, Ewing, Charles M., Zhang, Liti, Novakovic, Kristian, Petkewicz, Jacqueline, Gulukota, Kamalakar, Helseth Jr, Donald L., Quinn, Margo, Humphries, Elizabeth, Wiley, Kathleen E., Isaacs, Sarah D., Wu, Yishuo, Liu, Xu, Zhang, Ning, Wang, Chi-Hsiung, Khandekar, Janardan, Hulick, Peter J., Shevrin, Daniel H., Cooney, Kathleen A., Shen, Zhoujun, Partin, Alan W., Carter, H. Ballentine, Carducci, Michael A., Eisenberger, Mario A., Denmeade, Sam R., McGuire, Michael, Walsh, Patrick C., Helfand, Brian T., Brendler, Charles B., Ding, Qiang, Xu, Jianfeng, Isaacs, William B.

Publikováno v: In European Urology May 2017 71(5):740-747

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression.

Autor: Chen J; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Zheng Q; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hicks JL; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Trabzonlu L; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ozbek B; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jones T; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vaghasia A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Larman TC; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wang R; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Markowski MC; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Denmeade SR; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Pienta KJ; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hruban RH; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medicine, Baltimore, Maryland, USA., Antonarakis ES; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Gupta A; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Dang CV; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Yegnasubramanian S; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., De Marzo AM; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 10. Date of Electronic Publication: 2023 Mar 10.